Figure 2. Transcriptional repression by CtBP1.

Figure 2

Transcriptional repression by CtBP1. A prototypical DNA-binding repressor (such as ZEB) is depicted to recruit CtBP1 (through the PXDLS motif) and the associated proteins to transcriptionally active areas chromatin in which histone H3 is acetylated (K9) and methylated (K4). During transcriptional repression, the HDACs deacetylate H3-K9 followed by methylation by HMTase. The methylated K4 residue of histone H3 is demethylated by the action of LSD1. It has been suggested that hypoacetylated nucleosomes may be the preferred targets for LSD1,44 suggesting demethylation of H3-K4 may be a subsequent event after deacetylation of H3-K9. The resulting CH2O may serve as a potential methyl donor for the action of HMTase.91 The HPC2 moiety in the CtBP1 complex, in addition to playing a role in sumoylation (by recruiting Ubc9) may also directly interact with the chromatin via methylated H3-K27.92-94

From: CtBP Family Proteins: Unique Transcriptional Regulators in the Nucleus with Diverse Cytosolic Functions

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