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National Clinical Guideline Centre (UK). Anaemia Management in Chronic Kidney Disease: Rapid Update 2011 [Internet]. London: Royal College of Physicians (UK); 2011 Feb. (NICE Clinical Guidelines, No. 114.)

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Anaemia Management in Chronic Kidney Disease: Rapid Update 2011 [Internet].

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Appendix AEvidence-based clinical questions and literature searches

A.1. Evidence-based clinical questions and literature searches [2006]

Question IDQuestion wordingStudy type filters usedDatabases and years
PROG1In patients with chronic kidney disease, what haemoglobin (Hb)/haematocrit levels are associated with adverse outcomes and what are the effects of a) age b) gender c) ethnicity?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
DIAG1In patients with chronic kidney disease, what is the association between glomerular filtration rate (GFR) and haemoglobin levels in a) diabetic and b) non- diabetic patients?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
DTEST2What are the best tests, or combination of tests, to determine iron status in patients with chronic kidney disease?DiagnosisMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
DTEST1What is the role of erythropoietin testing in the assessment of anaemia in patients with chronic kidney disease?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
MGTFE1Up to what levels of serum ferritin, percentage transferrin saturation and percentage hypochromic red cells should patients with ACKD be treated with iron without adverse events?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
MGTFE2In patients with ACKD what, if any, are the serum ferritin, transferrin saturation and percentage hypochromic red cells thresholds for commencing treatment with ESAs?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
MGTFE3In patients with ACKD what, if any, are the optimal serum ferritin, transferrin saturation and percentage hypochromic red cells levels to be maintained during treatment with ESAs?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
MGTN1What is the benefit of vitamin C, vitamin E, folic acid, carnitine or glutathione supplementation in the treatment of anaemia due to chronic kidney disease?Systematic reviews and RCTsMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
MGTN2What is the benefit of androgens in the treatment of anaemia due to chronic kidney disease?Systematic reviews and RCTsMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
HYP1When does treating hyperparathyroidism improve the management of anaemia caused by chronic kidney disease?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
PAT1What are the patient preferences and experiences when receiving ESAs for the treatment of ACKD?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
BNI 1985–2005
PAT2Is the effectiveness of anaemia management of CKD improved by patient education programmes?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
BNI 1985–2005
PsycInfo 1806–2005
MGTHB1What haemoglobin range should be maintained during anaemia treatment in CKD?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
MGTHB2In patients with chronic kidney disease what are the risks and benefits of early vs deferred correction of anaemia?Systematic reviews and RCTsMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
TXFE1What is the most effective and safest dose, frequency, preparation and route of administration of iron in ACKD patients with functional iron deficiency prior to ESA treatment?Systematic reviews and RCTsMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
TXFE2What is the most effective and safest dose, frequency, preparation and route of administration of iron in ACKD patients with functional iron deficiency receiving ESA treatment?Systematic reviews and RCTsMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
TXEF1In patients with ACKD what are the benefits and risks of correcting anaemia with epoetin alfa compared to epoetin beta in reducing morbidity and mortality and improving quality of life?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
TXEF2In patients with ACKD what are the benefits and risks of correcting anaemia with epoetin alfa compared to darbepoetin in reducing morbidity and mortality and improving quality of life?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
TXEF3In patients with ACKD what are the benefits and risks of correcting anaemia with epoetin beta compared to darbepoetin in reducing morbidity and mortality and improving quality of life?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
TXEF4In patients with ACKD what are the benefits and risks of correcting anaemia with ESAs compared to placebo or no treatment in reducing morbidity and mortality and improving quality of life?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
MGTE1Which iron replete patients with ACKD should receive ESAs?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
TXEF5In patients with ACKD what are the benefits and risks of correcting anaemia with blood transfusions in reducing morbidity and mortality and improving quality of life?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
TXDF1In patients with ACKD, what factors (including patient factors) determine the dose and frequency of ESA required to correct anaemia?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
TXDF2In patients with ACKD, what factors determine the dose and frequency of ESA required to keep the haemoglobin level within the maintenance range?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
ESAD1In patients with ACKD, what factors determine the provision of ESAs?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
ESAD2In patients with ACKD, what factors determine the route of administration of ESAs?Systematic reviews, RCTs and comparative studiesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
NURS1Is the effectiveness of anaemia management in chronic kidney disease improved by the involvement of anaemia nurse specialists/coordinators?All study types including qualitativeMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
MON1In patients with ACKD treated with ESAs, how frequently should iron status be checked?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
MON2In patients with ACKD treated with ESAs, how frequently should haemoglobin levels be checked a) during Hb correction and b) during Hb maintenance?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
ESAR1When should resistance to ESAs be suspected and what conditions lead to ESA resistance?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005
ESAR2How should ESA resistance be managed?All study typesMedline 1966–2005
Embase 1980–2005
Cochrane 1800–2005
Cinahl 1982–2005

NOTE: The final cut-off date for all searches was 28 September 2005.

A.2. Literature search strategies [2011]

Search strategies used for the AMCKD guideline are outlined below and were run as per the NICE Guidelines Manual 2009 http://www.nice.org.uk/media/5F2/44/The_guidelines_manual_2009_-_All_chapters.pdf

Searches for the clinical reviews were run in Medline (OVID), Embase (OVID), the Cochrane Library and Cinahl (EBSCO).

Searches for the health economic reviews were run in Medline (Ovid), Embase (Ovid), the NHS Economic Evaluations Database (NHS EED), the Health Technology Assessments database (HTA) and the Health Economic Evaluation Database (HEED). NHSEED and HTA were searched via The Cochrane Library. Searches in NHS EED, HTA and HEED were constructed only using population terms. For Medline and Embase an economics filter (instead of a study type filter) was added to the population search strategy.

Searches were based on those done for the original 2006 guideline. All searches were run from the original search date (2005) to 8th July 2010. The Cochrane Library was searched to Issue 3, July 2010 with the exception of the Cochrane Database of Systematic Reviews which was searched to Issue 7, July 2010.

The full searches are presented below.

A.2.1. Diagnostic search strategies

The following searches for chapter 4.1 relate to the clinical question:

In patients with chronic kidney disease, at what haemoglobin (Hb)/haematocrit (Hct) levels should treatment commence?

Medline search terms

No.Search terms
1kidney failure, chronic/
2exp renal insufficiency, chronic/
3(chronic adj2 (renal or kidney)).ti,ab.
4((endstage or (end adj1 stage)) adj2 (renal or kidney)).ti,ab.
5esrd.ti,ab.
6exp renal replacement therapy/
7kidney diseases/and (chronic$ or end-stage or endstage).ti,ab.
8kidney failure/and (chronic$ or end-stage or endstage).ti,ab.
9((renal adj3 insufficienc$) not (acute adj2 renal)).ti,ab.
10(predialysis or hemodialysis or haemodialysis or dialys*).ti,ab.
11or/1–10
12(anemi* or anaemi*).ti,ab.
13exp anemia/
14or/12–13
1511 and 14
16hematocrit/
17exp hemoglobins/
18(hemoglobin* or haemoglobin* or hematocrit* or haematocrit*).ti,ab.
19(hb or hct).ti,ab.
20or/16–19
2111 and 20
22exp mortality/
23mo.fs.
24quality of life/
25quality-adjusted life years/
26treatment outcome/
27exp prognosis/
28exp cardiovascular diseases/
29exp stroke/
30exp blood transfusion/
31exp “outcome and process assessment (health care)”/
32(adverse adj (outcome* or event*)).ti,ab.
33or/22–32
3421 and 33
35limit 34 to english language
36letter.pt.
37letter/
38letter$/
39editorial.pt.
40historical article.pt.
41anecdote.pt.
42commentary.pt.
43note.pt.
44case report/
45case report$.pt.
46case study/
47case study.pt.
48exp animal/not human/
49nonhuman/
50exp animal studies/
51animals, laboratory/
52exp experimental animal/
53exp animal experiment/
54exp animal model/
55exp rodentia/
56exp rodents/
57exp rodent/
58or/36–57
5935 not 58

Embase search terms

No.Search terms
1chronic kidney failure/
2chronic kidney disease/
3(chronic adj2 (renal or kidney)).ti,ab.
4((endstage or (end adj1 stage)) adj2 (renal or kidney)).ti,ab.
5esrd.ti,ab.
6exp renal replacement therapy/
7kidney disease/and (chronic$ or end-stage or endstage).ti,ab.
8kidney failure/and (chronic$ or end-stage or endstage).ti,ab.
9((renal adj3 insufficienc$) not (acute adj2 renal)).ti,ab.
10(predialysis or hemodialysis or haemodialysis or dialys*).ti,ab.
11or/1–10
12(anemi* or anaemi*).ti,ab.
13exp anemia/
14or/12–13
1511 and 14
16hematocrit/
17exp hemoglobin/
18(hemoglobin* or haemoglobin* or hematocrit* or haematocrit*).ti,ab.
19(hb or hct).ti,ab.
20or/16–19
2111 and 20
22exp mortality/
23exp “quality of life”/
24exp treatment outcome/
25prognosis/
26exp cardiovascular disease/
27exp stroke/
28exp blood transfusion/
29(adverse adj (outcome* or event*)).ti,ab.
30or/22–29
3121 and 30
32letter.pt.
33letter/
34letter$/
35editorial.pt.
36historical article.pt.
37anecdote.pt.
38commentary.pt.
39note.pt.
40case report/
41case report$.pt.
42case study/
43case study.pt.
44exp animal/not human/
45nonhuman/
46exp animal studies/
47animals, laboratory/
48exp experimental animal/
49exp animal experiment/
50exp animal model/
51exp rodentia/
52exp rodents/
53exp rodent/
54or/32–53
5531 not 54

Cinahl search terms

No.Search terms
S16S10 and S15
S15S11 or S12 or S13 or S14
S14hb or hct
S13(hemoglobin* or haemoglobin* or hematocrit* or haematocrit*)
S12(MH “Hemoglobins+”)
S11(MH “Hematocrit”)
S10S1 or S2 or S3 or S4 or S5 or S6 or S7 or S8 or S9
S9(predialysis or hemodialysis or haemodialysis or dialys*)
S8((renal and insufficienc*) not (acute and renal))
S7(MH “Kidney Failure”) and (chronic* or end-stage or endstage)
S6(MH “Kidney Diseases”) and (chronic* or end-stage or endstage)
S5(MH “Renal Replacement Therapy+”)
S4esrd
S3((endstage or (end stage) or end-stage) and (renal or kidney))
S2(chronic and (renal or kidney))
S1(MH “Kidney Failure, Chronic”)

Cochrane search terms

No.Search terms
#1MeSH descriptor Kidney Failure, Chronic explode all trees
#2MeSH descriptor Renal Insufficiency, Chronic explode all trees
#3(chronic near/2 (renal or kidney)):ti,ab,kw
#4((endstage or (end near/1 stage)) near/2 (renal or kidney)):ti,ab,kw
#5esrd:ti,ab,kw
#6MeSH descriptor Renal Replacement Therapy explode all trees
#7((renal near/3 insufficienc*) not (acute near/2 renal)):ti,ab,kw
#8(predialysis or hemodialysis or haemodialysis or dialys*):ti,ab,kw
#9(#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8)
#10MeSH descriptor Kidney Diseases, this term only
#11MeSH descriptor Kidney Failure, this term only
#12(chronic* or end-stage or endstage):ti,ab,kw
#13(#10 AND #12)
#14(#11 AND #12)
#15(#9 OR #13 OR #14)
#16(anemi* or anaemi*):ti,ab,kw
#17MeSH descriptor Anemia explode all trees
#18(#16 OR #17)
#19(#15 AND #18)
#20MeSH descriptor Hematocrit, this term only
#21MeSH descriptor Hemoglobins explode all trees
#22(hemoglobin* or haemoglobin* or hematocrit* or haematocrit*):ti,ab,kw
#23(hb or hct):ti,ab,kw
#24(#20 OR #21 OR #22 OR #23)
#25(#15 AND #24)

A.2.2. Optimal search strategies

The following searches for chapter 4.1 relate to the clinical question:

What should be the optimum Haemoglobin target range for patients undergoing treatment for anaemia in CKD?

Medline search terms

No.Search terms
1kidney failure, chronic/
2exp renal insufficiency, chronic/
3(chronic adj2 (renal or kidney)).ti,ab.
4((endstage or (end adj1 stage)) adj2 (renal or kidney)).ti,ab.
5esrd.ti,ab.
6exp renal replacement therapy/
7kidney diseases/and (chronic$ or end-stage or endstage).ti,ab.
8kidney failure/and (chronic$ or end-stage or endstage).ti,ab.
9((renal adj3 insufficienc$) not (acute adj2 renal)).ti,ab.
10(predialysis or hemodialysis or haemodialysis or dialys*).ti,ab.
11or/1–10
12(anemi* or anaemi*).ti,ab.
13exp anemia/
14or/12–13
1511 and 14
16exp hemoglobins/
17hematocrit/
18(hemoglobin* or haemoglobin* or hematocrit* or haematocrit*).ti,ab.
19(hb or hct).ti,ab.
20or/16–19
2115 and 20
22(range* or target* or level* or maintain* or maintenance).ti,ab.
2321 and 22
24letter.pt.
25letter/
26letter$/
27editorial.pt.
28historical article.pt.
29anecdote.pt.
30commentary.pt.
31note.pt.
32case report/
33case report$.pt.
34case study/
35case study.pt.
36exp animal/not human/
37nonhuman/
38exp animal studies/
39animals, laboratory/
40exp experimental animal/
41exp animal experiment/
42exp animal model/
43exp rodentia/
44exp rodents/
45exp rodent/
46or/24–45
4723 not 46

Embase search terms

No.Search terms
1chronic kidney failure/
2chronic kidney disease/
3(chronic adj2 (renal or kidney)).ti,ab.
4((endstage or (end adj1 stage)) adj2 (renal or kidney)).ti,ab.
5esrd.ti,ab.
6exp renal replacement therapy/
7kidney disease/and (chronic$ or end-stage or endstage).ti,ab.
8kidney failure/and (chronic$ or end-stage or endstage).ti,ab.
9((renal adj3 insufficienc$) not (acute adj2 renal)).ti,ab.
10(predialysis or hemodialysis or haemodialysis or dialys*).ti,ab.
11or/1–10
12(anemi* or anaemi*).ti,ab.
13exp anemia/
14or/12–13
1511 and 14
16hematocrit/
17exp hemoglobin/
18(hemoglobin* or haemoglobin* or hematocrit* or haematocrit*).ti,ab.
19(hb or hct).ti,ab.
20or/16–19
2115 and 20
22(range* or target* or level* or maintain* or maintenance).ti,ab.
2321 and 22
24letter.pt.
25letter/
26letter$/
27editorial.pt.
28historical article.pt.
29anecdote.pt.
30commentary.pt.
31note.pt.
32case report/
33case report$.pt.
34case study/
35case study.pt.
36exp animal/not human/
37nonhuman/
38exp animal studies/
39animals, laboratory/
40exp experimental animal/
41exp animal experiment/
42exp animal model/
43exp rodentia/
44exp rodents/
45exp rodent/
46or/24–45
4723 not 46

Cinahl search terms

No.Search terms
S22S20 and S21
S21(range* or target* or level* or maintain* or maintenance)
S20S16 and S19
S19S17 or S18
S18anaemi* or anemi*
S17(MH “Anemia+”)
S16S10 and S15
S15S11 or S12 or S13 or S14
S14hb or hct
S13(hemoglobin* or haemoglobin* or hematocrit* or haematocrit*)
S12(MH “Hemoglobins+”)
S11(MH “Hematocrit”)
S10S1 or S2 or S3 or S4 or S5 or S6 or S7 or S8 or S9
S9(predialysis or hemodialysis or haemodialysis or dialys*)
S8((renal and insufficienc*) not (acute and renal))
S7(MH “Kidney Failure”) and (chronic* or end-stage or endstage)
S6(MH “Kidney Diseases”) and (chronic* or end-stage or endstage)
S5(MH “Renal Replacement Therapy+”)
S4esrd
S3((endstage or (end stage) or end-stage) and (renal or kidney))
S2(chronic and (renal or kidney))
S1(MH “Kidney Failure, Chronic”)

Cochrane search terms

No.Search terms
#1MeSH descriptor Kidney Failure, Chronic explode all trees
#2MeSH descriptor Renal Insufficiency, Chronic explode all trees
#3(chronic near/2 (renal or kidney)):ti,ab,kw
#4((endstage or (end near/1 stage)) near/2 (renal or kidney)):ti,ab,kw
#5esrd:ti,ab,kw
#6MeSH descriptor Renal Replacement Therapy explode all trees
#7((renal near/3 insufficienc*) not (acute near/2 renal)):ti,ab,kw
#8(predialysis or hemodialysis or haemodialysis or dialys*):ti,ab,kw
#9(#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8)
#10MeSH descriptor Kidney Diseases, this term only
#11MeSH descriptor Kidney Failure, this term only
#12(chronic* or end-stage or endstage):ti,ab,kw
#13(#10 AND #12)
#14(#11 AND #12)
#15(#9 OR #13 OR #14)
#16(anemi* or anaemi*):ti,ab,kw
#17MeSH descriptor Anemia explode all trees
#18(#16 OR #17)
#19(#15 AND #18)
#20MeSH descriptor Hematocrit, this term only
#21MeSH descriptor Hemoglobins explode all trees
#22(hemoglobin* or haemoglobin* or hematocrit* or haematocrit*):ti,ab,kw
#23(hb or hct):ti,ab,kw
#24(#20 OR #21 OR #22 OR #23)
#25(#19 AND #24)
#26(range* or target* or level* or maintain* or maintenance):ti,ab
#27(#25 AND #26)

A.2.3. Economics search strategies

The following searches relate to health economics.

Medline search terms

No.Search terms
1kidney failure, chronic/
2exp renal insufficiency, chronic/
3(chronic adj2 (renal or kidney)).ti,ab.
4((endstage or (end adj1 stage)) adj2 (renal or kidney)).ti,ab.
5esrd.ti,ab.
6exp renal replacement therapy/
7kidney diseases/ and (chronic$ or end-stage or endstage).ti,ab.
8kidney failure/ and (chronic$ or end-stage or endstage).ti,ab.
9((renal adj3 insufficienc$) not (acute adj2 renal)).ti,ab.
10(predialysis or hemodialysis or haemodialysis or dialys*).ti,ab.
11or/1–10
12(anemi* or anaemi*).ti,ab.
13exp anemia/
14or/12–13
1511 and 14
16exp “costs and cost analysis”/
17economics/
18exp economics, hospital/
19exp economics, medical/
20exp economics, nursing/
21exp economics, pharmaceutical/
22exp “fees and charges”/
23exp budgets/
24ec.fs.
25(economic$ or pharmacoeconomic$ or price$ or pricing$ or cost$ or budget$).ti,ab.
26(value adj2 (money or monetary)).ti,ab.
27(expenditure not energy).ti,ab.
28or/16–27
29((metabolic or energy or oxygen) adj1 cost$).ti,ab.
3028 not 29
31exp quality-adjusted life years/
32quality adjusted life.tw.
33exp “quality of life”/
34value of life/
35(qaly$ or qald$ or qale$ or qtime$).tw.
36disability adjusted life.tw.
37daly$.tw.
38health status indicators/
39(sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw.
40(sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw.
41(sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw.
42(sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw.
43(sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw.
44(euroqol or euro qol or eq5d or eq 5d).tw.
45(hql or hqol or h qol or hrqol or hr qol).tw.
46(hye or hyes).tw.
47health$ year$ equivalent$.tw.
48health utilit$.tw.
49(hui or hui1 or hui2 or hui3).tw.
50disutili$.tw.
51rosser.tw.
52quality of well?being.tw.
53qwb.tw.
54willingness to pay.tw.
55standard gamble$.tw.
56time trade off.tw.
57time tradeoff.tw.
58tto.tw.
59or/31–58
6030 or 59
6115 and 60

Embase search terms

No.Search terms
1chronic kidney failure/
2chronic kidney disease/
3(chronic adj2 (renal or kidney)).ti,ab.
4((endstage or (end adj1 stage)) adj2 (renal or kidney)).ti,ab.
5esrd.ti,ab.
6exp renal replacement therapy/
7kidney disease/ and (chronic$ or end-stage or endstage).ti,ab.
8kidney failure/ and (chronic$ or end-stage or endstage).ti,ab.
9((renal adj3 insufficienc$) not (acute adj2 renal)).ti,ab.
10(predialysis or hemodialysis or haemodialysis or dialys*).ti,ab.
11or/1–10
12(anemi* or anaemi*).ti,ab.
13exp anemia/
14or/12–13
1511 and 14
16health economics/
17exp economic evaluation/
18exp health care cost/
19exp pharmacoeconomics/
20exp fee/
21budget/
22(economic$ or pharmacoeconomic$ or cost$ or price$ or pricing$ or budget$).ti,ab.
23(value adj2 (money or monetary$)).ti,ab.
24(expenditure not energy).ti,ab.
25or/16–24
26((metabolic or energy or oxygen) adj1 cost$).ti,ab.
2725 not 26
28quality adjusted life year/
29quality of life/
30(qaly$ or qald$ or qale$ or qtime$).tw.
31daly$.tw.
32quality adjusted life.tw.
33disability adjusted life.tw.
34(sf36 or sf 36 or short form 36 or shortform 36 or sf thirtysix or sf thirty six or shortform thirtysix or shortform thirty six or short form thirtysix or short form thirty six).tw.
35(sf6 or sf 6 or short form 6 or shortform 6 or sf six or sfsix or shortform six or short form six).tw.
36(sf12 or sf 12 or short form 12 or shortform 12 or sf twelve or sftwelve or shortform twelve or short form twelve).tw.
37(sf16 or sf 16 or short form 16 or shortform 16 or sf sixteen or sfsixteen or shortform sixteen or short form sixteen).tw.
38(sf20 or sf 20 or short form 20 or shortform 20 or sf twenty or sftwenty or shortform twenty or short form twenty).tw.
39(euroqol or euro qol or eq5d or eq 5d).tw.
40(hql or hqol or h qol or hrqol or hr qol).tw.
41(hye or hyes).tw.
42health$ year$ equivalent$.tw.
43health utilit$.tw.
44(hui or hui1 or hui2 or hui3).tw.
45disutili$.tw.
46rosser.tw.
47quality of well?being.tw.
48qwb.tw.
49willingness to pay.tw.
50standard gamble$.tw.
51time trade off.tw.
52time tradeoff.tw.
53tto.tw.
54or/28–53
5527 or 54
5615 and 55

Cochrane search terms (NHSEED/HTA)

No.Search terms
#1MeSH descriptor Kidney Failure, Chronic explode all trees
#2MeSH descriptor Renal Insufficiency, Chronic explode all trees
#3(chronic near/2 (renal or kidney)):ti,ab,kw
#4((endstage or (end near/1 stage)) near/2 (renal or kidney)):ti,ab,kw
#5esrd:ti,ab,kw
#6MeSH descriptor Renal Replacement Therapy explode all trees
#7((renal near/3 insufficienc*) not (acute near/2 renal)):ti,ab,kw
#8(predialysis or hemodialysis or haemodialysis or dialys*):ti,ab,kw
#9(#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8)
#10MeSH descriptor Kidney Diseases, this term only
#11MeSH descriptor Kidney Failure, this term only
#12(chronic* or end-stage or endstage):ti,ab,kw
#13(#10 AND #12)
#14(#11 AND #12)
#15(#9 OR #13 OR #14)
#16(anemi* or anaemi*):ti,ab,kw
#17MeSH descriptor Anemia explode all trees
#18(#16 OR #17)
#19(#15 AND #18)

HEED search terms (Compound search)

All Data(chronic or endstage or end-stage)OR
All Data(renal or kidney)OR
All Data(predialys* or hemodialys* or haemodialys* or dialys*)OR
All Dataanemi* or anaemi*AND
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Bookshelf ID: NBK65525
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