CID/ML No.Target NameTarget IC50 (μM) [SID, AID]Anti-target NameAnti-target IC50 (μM) [SID, AID]Fold selectiveSecondary Assay 1 IC50 (μM) [SID, AID]Secondary Assay 2 IC50 (μM) [SID, AID]Secondary Assay 3 IC50 (μM) [SID, AID]
46907798/ML187Cytokine-induced beta cell apoptosis3.5 [SID-99376568, 488844]Beta-cell apoptosis in the absence of cytokinesNo activity up to 25 μM [99376568,488864]>10XCytokine-induced beta-cell apoptosis counter screen 2.2 [99376568, 4888936]Suppresses caspase-3 activation in primary human islets 6.7 [99376568, 488945]Restores glucose-stimulated insulin secretion in rat INS-1E cells 4.8 [99376568, 488951]

From: Identification of Small Molecule Inhibitors that Suppress Cytokine-Induced Apoptosis in Human Pancreatic Islet Cells

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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