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National Collaborating Centre for Cancer (UK). Metastatic Spinal Cord Compression: Diagnosis and Management of Patients at Risk of or with Metastatic Spinal Cord Compression. Cardiff (UK): National Collaborating Centre for Cancer (UK); 2008 Nov. (NICE Clinical Guidelines, No. 75.)

Cover of Metastatic Spinal Cord Compression

Metastatic Spinal Cord Compression: Diagnosis and Management of Patients at Risk of or with Metastatic Spinal Cord Compression.

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Appendix ALiterature Searches

NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: What is the most effective way of delivering care and co-ordinating services for patients with MSCC or suspected MSCC?
Question no: 11a
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20072103816/03/07
Premedline1950 – 20070016/03/07
Embase1980 – 200712473516/03/07
Cochrane Library1800 – 200735016/03/07
Cinahl1982 – 2007611016/03/07
BNI1994 – 20070016/03/07
Psychinfo1967– 20071016/03/07
SIGLE1980 – 20050019/03/07
Web of Science (SCI & SSCI)1970 – 20072201819/03/07
ISI Proceedings1990 – 200730219/03/07
Biomed Central1997 – 2007384019/03/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/200821018/04/08
Premedline2007 – 04/20082018/04/08
Embase2007 – 04/20084118/04/08
Cochrane Library2007 – 04/200815018/04/08
Cinahl2007 – 04/200811018/04/08
BNI2007 – 04/20080018/04/08
Psychinfo2007 – 04/20083018/04/08
Web of Science (SCI & SSCI)2007 – 04/200834118/04/08
ISI Proceedings2007 – 04/20083018/04/08
Biomed Central2007 – 04/2008160018/04/08
Total References retrieved (after de-duplication): 80 (update search: 2)
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord Compression AND multidisciplinary teams
  1. exp Spinal Neoplasms/
  2. (spin$ adj metasta$).tw.
  3. (spin$ adj (cancer$ or carcinoma$ or malignan$ or tumo?r$ or neoplas$ or intraepithelial$ or adeno$)).tw.
  4. exp Spinal Cord Compression/
  5. (skelet$ adj3 event$).tw.
  6. or/1–5
  7. exp Patient Care Planning/
  8. exp Patient Care Team/
  9. multidisciplin$ team$.tw.
  10. (health adj1 team$).tw.
  11. interdisciplin$ team$.tw.
  12. exp "Delivery of Health Care"/
  13. (cooperat$ or co-operat$).tw.
  14. multiprofession$.tw.
  15. exp "Referral and Consultation"/
  16. exp Physician's Practice Patterns/
  17. exp "Practice Guideline [Publication Type]"/
  18. or/7–17
  19. 6 and 18
Health Economics Literature search details
A Health Economics Literature search was not required.
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: In patients with MSCC, what effect does delay from presentation to definitive treatment have on clinical outcomes (mobility, urinary continence, lack of pain, survival independent living)?
Question no: 5a
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20065686630/10/06
Premedline1950 – 20061031/10/06
Embase1980 – 20066503731/10/06
Cochrane Library1800 – 20062031/10/06
Cinahl1982 – 200612031/10/06
BNI1994 – 200613031/10/06
Psychinfo1967 – 200610031/10/06
SIGLE1980 – 20050031/10/06
Web of Science (SCI & SSCI)1970 – 200699931/10/06
ISI Proceedings1990 – 20065331/10/06
Biomed Central1997 – 2006166031/10/06
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2006 – 04/200810218/04/08
Premedline2006 – 04/20082018/04/08
Embase2006 – 04/200824818/04/08
Cochrane Library2006 – 04/20083018/04/08
Cinahl2006 – 04/200810118/04/08
BNI2006 – 04/20080018/04/08
Psychinfo2006 – 04/20084018/04/08
Web of Science (SCI & SSCI)2006 – 04/200825118/04/08
ISI Proceedings2006 – 04/20085018/04/08
Biomed Central2006 – 04/20084018/04/08
Total References retrieved (after de-duplication): 96 (update search: 11)
Medline search strategy (This search strategy is adapted to each database.)
Spinal Cord Compression AND Metastasis AND (Time Factors OR Delay) AND (Mobility OR Continence OR Pain)
  1. Spinal Cord Compression/
  2. (spin$ adj2 compress$).tw.
  3. (compress$ adj1 myelopath$).tw.
  4. (MSCC or MESCC or SCC).tw.
  5. or/1–4
  6. exp Neoplasm Metastasis/
  7. exp Spinal Cord Neoplasms/
  8. (metasta$ adj spin$).tw.
  9. or/6–8
  10. 5 and 9
  11. exp Time Factors/
  12. (delay$ adj treatment$).tw.
  13. (delay$ adj presentation$).tw.
  14. exp Follow-Up Studies/
  15. exp Risk Assessment/
  16. exp Treatment Outcome/
  17. or/11–17
  18. 10 and 18
  19. exp Urinary Incontinence/
  20. exp Pain/
  21. (lack adj2 pain$).tw.
  22. exp Survival/px, sn, ph [Psychology, Statistics & Numerical Data, Physiology]
  23. mobilit$.tw.
  24. exp Movement/
  25. exp Motor Activity/
  26. exp Kinesis/
  27. exp "Activities of Daily Living"/
  28. independent liv$.tw.
  29. or/20–29
Health Economics Literature search details

SIGN Health Economics and SCHARR Quality of Life filter added to search.
Database nameNo of references foundFinish date of search
Medline430/04/07
Premedline030/04/07
Embase030/04/07
Cochrane Library (except NHSEED)030/04/07
NHSEED030/04/07
Cinahl030/04/07
Psycinfo030/04/07
BNI030/04/07
EconLit030/04/07
Web of Science (SCI & SSCI)030/04/07
ISI Proceedings030/04/07
SIGLE030/04/07
UPDATE SEARCH
Database nameNo of references foundFinish date of search
Medline018/04/08
Premedline018/04/08
Embase018/04/08
Cochrane Library (except NHSEED)018/04/08
NHSEED018/04/08
Cinahl018/04/08
Psycinfo018/04/08
BNI018/04/08
EconLit018/04/08
Web of Science (SCI & SSCI)018/04/08
ISI Proceedings018/04/08
Any further comments:
The update search was performed to include the years 2006 – 18 April 2008 only.
The Health Economics update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: : In patients with MSCC, what effect does performance status at the time of treatment have on clinical outcomes (mobility, urinary continence, lack of pain, survival independent living)?
Question no: 5b
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20061372301/11/06
Premedline1950 – 20060001/11/06
Embase1980 – 20062102402/11/06
Cochrane Library1800 – 200620001/11/06
Cinahl1982 – 20069101/11/06
BNI1994 – 20060001/11/06
Psychinfo1967 – 20062001/11/06
SIGLE1980 – 20050002/11/06
Web of Science (SCI & SSCI)1970 – 20062171406/11/06
ISI Proceedings1990 – 200618006/11/06
Biomed Central1997 – 2006119006/11/06
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2006 – 04/2008321118/04/08
Premedline2006 – 04/20082118/04/08
Embase2006 – 04/2008731218/04/08
Cochrane Library2006 – 04/200811118/04/08
Cinahl2006 – 04/20087118/04/08
BNI2006 – 04/20080018/04/08
Psychinfo2006 – 04/20082018/04/08
Web of Science (SCI & SSCI)2006 – 04/200860518/04/08
ISI Proceedings2006 – 04/20085018/04/08
Biomed Central2006 – 04/200836018/04/08
Total References retrieved (after de-duplication): 46 (update search: 16)
Medline search strategy (This search strategy is adapted to each database.)
Spinal Cord Compression AND Metastasis AND Performance Status
  1. Spinal Cord Compression/
  2. (spin$ adj2 compress$).tw.
  3. (compress$ adj1 myelopath$).tw.
  4. (MSCC or MESCC).tw.
  5. or/1–4
  6. exp Spinal Cord Neoplasms/
  7. (metasta$ adj2 spin$ cord$).tw.
  8. exp Neoplasm Metastasis/
  9. or/6–8
  10. 5 and 9
  11. performance$ status$.tw.
  12. (Eastern Cooperative Oncology Group or ECOG).tw.
  13. exp Karnofsky Performance Status/
  14. performance measur$.tw.
  15. exp "Outcome and Process Assessment (Health Care)"/
  16. (grad$ or scor$).tw.
  17. or/11–16
  18. 10 and 17
Health Economics Literature search details
A Health Economics Literature search was not required
Any further comments:
The update search as performed to include the years 2006 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: What is the most effective way to communicate the symptoms of MSCC to patients with primary carcinoma [to your patient]?
Question no: 18
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20079101/08/07
Premedline1950 – 20070001/08/07
Embase1980 – 200710101/08/07
Cochrane Library1800 – 200718001/08/07
Cinahl1982 – 20070001/08/07
BNI1994 – 20070001/08/07
Psychinfo1967 – 20070001/08/07
SIGLE1980 – 20050001/08/07
Web of Science (SCI & SSCI)1970 – 200722201/08/07
ISI Proceedings1990 – 200727006/08/07
Biomed Central1997 – 20070006/08/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/20082018/04/08
Premedline2007 – 04/20082118/04/08
Embase2007 – 04/20083018/04/08
Cochrane Library2007 – 04/20082018/04/08
Cinahl2007 – 04/20081018/04/08
BNI2007 – 04/20080018/04/08
Psychinfo2007 – 04/20080018/04/08
Web of Science (SCI & SSCI)2007 – 04/20084118/04/08
ISI Proceedings2007 – 04/20081018/04/08
Biomed Central2007 – 04/20080018/04/08
Total References retrieved (after de-duplication): 4 (update search: ) 1
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord Compression AND Risk AND Communication
  1. exp Spinal Cord Compression/
  2. (spin$ adj2 compress$).tw.
  3. (compress$ adj1 myelopath$).tw.
  4. (MSCC or MESCC).tw.
  5. (nerv$ root$ adj compress$).tw.
  6. vertebra$ collaps$.tw.
  7. spin$ collaps$.tw.
  8. or/1–7
  9. exp risk/
  10. risk$.tw.
  11. exp disease susceptibility/
  12. susceptib$.tw.
  13. or/9–12
  14. communication/
  15. persuasive communication/
  16. counseling/
  17. health promotion/
  18. consumer participation/
  19. patient education/
  20. decision making/
  21. informed consent/
  22. ((patient$ or consumer$) adj3 (communicat$ or counsel$ or inform$ or discuss$ or decision$ or decid$ or participat$)).tw.
  23. "Patient Acceptance of Health Care"/
  24. choice behavior/
  25. or/14–24
  26. 13 and 25
  27. 8 and 26
Health Economics Literature search details
A Health Economics Literature search was not required.
Any further comments:
Poor evidence.
The update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: In patients with cancer at risk of developing spinal cord compression, what symptoms and signs give early indications that malignant SCC is developing?
Question no: 3
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 200697518116/10/06
Premedline1950 – 20067316/10/06
Embase1980 – 200693819817/10/06
Cochrane Library1800 – 200657116/10/06
Cinahl1982 – 2006632616/10/06
BNI1994 – 20064116/10/06
Psychinfo1967 – 20064116/10/06
SIGLE1980 – 20051017/10/06
Web of Science (SCI & SSCI)1970 – 20063055617/10/06
ISI Proceedings1990 – 200614117/10/06
Biomed Central1997 – 200630017/10/06
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2006 – 04/20081352018/04/08
Premedline2006 – 04/20084318/04/08
Embase2006 – 04/2008234818/04/08
Cochrane Library2006 – 04/20082018/04/08
Cinahl2006 – 04/200832518/04/08
BNI2006 – 04/20082118/04/08
Psychinfo2006 – 04/20080018/04/08
Web of Science (SCI & SSCI)2006 – 04/200872618/04/08
ISI Proceedings2006 – 04/20084018/04/08
Biomed Central2006 – 04/200812018/04/08
Total References retrieved (after de-duplication): 355 (update search: 33)
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord Compression AND Cancer AND Diagnosis AND Symptoms
  1. Spinal Cord Compression/
  2. (spin$ adj2 compress$).tw.
  3. (compress$ adj1 myelopath$).tw.
  4. (MSCC or MESCC).mp.
  5. *Spinal Cord Compression/mo, pa, pp, di, pc, ra, ri, rt, ep, rh, su, et, th, us, hi [Mortality, Pathology, Physiopathology, Diagnosis, Prevention & Control, Radiography, Radionuclide Imaging, Radiotherapy, Epidemiology, Rehabilitation, Surgery, Etiology, Therapy, Ultrasonography, History]
  6. *Spinal Cord Neoplasms/mo, pa, pp, pc, ra, di, ri, rt, rh, ep, su, th, et, us, hi [Mortality, Pathology, Physiopathology, Prevention & Control, Radiography, Diagnosis, Radionuclide Imaging, Radiotherapy, Rehabilitation, Epidemiology, Surgery, Therapy, Etiology, Ultrasonography, History]
  7. or/1–6
  8. exp Pain/
  9. spin$ pain.tw.
  10. referred pain$.tw.
  11. exp Back Pain/
  12. exp Paralysis/
  13. Paresthesia/
  14. exp Paraparesis/
  15. exp Movement Disorders/
  16. exp Fecal Incontinence/or exp Urinary Incontinence/
  17. exp Valsalva Maneuver/
  18. Lhermitte sign.mp.
  19. symptom$.tw.
  20. or/8–21
  21. (cancer$ or carcinoma$ or malignan$ or tumo?r$ or adeno$ or neoplas$ or intraepithelial$).tw.
  22. Neoplasms/
  23. or/23–24
  24. exp Early Diagnosis/or exp Diagnosis/
  25. exp "Diagnostic Techniques and Procedures"/
  26. exp "Sensitivity and Specificity"/
  27. diagnos$.tw.
  28. exp Medical History Taking/
  29. exp Risk Factors/
  30. (clinical adj predict$).tw.
  31. (prognos$ adj factor$).tw.
  32. (predict$ adj factor$).tw.
  33. (prognos$ adj risk$).tw.
  34. (predict$ adj risk$).tw.
  35. (risk$ adj factor$).tw.
  36. or/26–38
  37. 7 and 22
  38. 40 and 25
  39. 41 and 39
Health Economics Literature search details

SIGN Health Economics and SCHARR Quality of Life filter added to search.
Database nameNo of references foundFinish date of search
Medline1013/02/07
Premedline913/02/07
Embase1713/02/07
Cochrane Library (except NHSEED)113/02/07
NHSEED013/02/07
Cinahl513/02/07
Psycinfo413/02/07
BNI413/02/07
EconLit013/02/07
Web of Science (SCI & SSCI)3613/02/07
ISI Proceedings513/02/07
SIGLE013/02/07
UPDATE SEARCH
Database nameNo of references foundFinish date of search
Medline018/04/08
Premedline018/04/08
Embase018/04/08
Cochrane Library (except NHSEED)018/04/08
NHSEED018/04/08
Cinahl018/04/08
Psycinfo018/04/08
BNI018/04/08
EconLit018/04/08
Web of Science (SCI & SSCI)018/04/08
ISI Proceedings018/04/08
Any further comments:
The update search was performed to include the years 2006 – 18 April 2008 only.
The Health Economics update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: In patients with suspected bone metastases in the spine, does MRI (or CT?) scanning (compared to not scanning) identify patients at risk of developing MSCC and improve outcomes (prevention of established MSCC, mobility, cost)
Question no: 1a
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 2007207914526/03/07
Premedline1950 – 200750427/03/07
Embase1980 – 200712725027/03/07
Cochrane Library1800 – 20077627/03/07
Cinahl1982 – 200767427/03/07
BNI1994 – 20078127/03/07
Psychinfo1967 – 2007254027/03/07
SIGLE1980 – 20050027/03/07
Web of Science (SCI & SSCI)1970 – 20072086427/03/07
ISI Proceedings1990 – 200714227/03/07
Biomed Central1997 – 200716027/03/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/20085218/04/08
Premedline2007 – 04/200859918/04/08
Embase2007 – 04/20088118/04/08
Cochrane Library2007 – 04/20086018/04/08
Cinahl2007 – 04/20081018/04/08
BNI2007 – 04/20080018/04/08
Psychinfo2007 – 04/20081018/04/08
Web of Science (SCI & SSCI)2007 – 04/200823518/04/08
ISI Proceedings2007 – 04/20081118/04/08
Biomed Central2007 – 04/200812118/04/08
Total References retrieved (after de-duplication): 215 (update search: 17)
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord Compression AND Bone metastases AND Imaging
RCT filter applied
  1. Spinal Cord Compression/
  2. (spin$ adj2 compress$).tw.
  3. 1 or 2
  4. exp "Bone and Bones"/
  5. exp Bone Neoplasms/
  6. (bon$ adj metastas$).tw.
  7. exp Spinal Cord Neoplasms/
  8. exp Spinal Neoplasms/
  9. (spin$ adj metastas$).tw.
  10. or/4–9
  11. 3 and 10
  12. Magnetic Resonance Spectroscopy/
  13. magnetic resonance.tw.
  14. MRI$1.tw.
  15. NMR$1.tw.
  16. MRS$1.tw.
  17. MRT.tw.
  18. MR imaging.tw.
  19. MR scan$.tw.
  20. MR spectroscop$.tw.
  21. (magnet$ adj3 (scan$ or imaging)).tw.
  22. (diffusion adj2 (scan$ or imaging)).tw.
  23. (functional adj2 (scan$ or imaging)).tw.
  24. exp Tomography, X-Ray Computed/
  25. (comput$ adj1 tomograph$).tw.
  26. ((ct or cat) adj (scan$ or imaging)).tw.
  27. electron beam computed tomography$.tw.
  28. 3-dimensional computerized tomography$.tw.
  29. (spiral adj CT).tw.
  30. ((multi$ slice or multi$ detector) adj CT).tw.
  31. Bone$ scintigraph$.tw.
  32. skelet$ survey$.tw.
  33. plain film$.tw.
  34. radioisotop$ bon$ scan$.tw.
  35. or/12–37
  36. 11 and 38
Health Economics Literature search details

SIGN Health Economics filter and SCHARR Quality of Life filter added to search.
Database nameNo of references foundFinish date of search
Medline1125/04/07
Premedline025/04/07
Embase1425/04/07
Cochrane Library (except NHSEED)202/05/07
NHSEED002/05/07
Cinahl125/04/07
Psycinfo1125/04/07
BNI025/04/07
EconLit025/04/07
Web of Science (SCI & SSCI)925/04/07
ISI Proceedings125/04/07
SIGLE025/04/07
UPDATE SEARCH
Database nameNo of references foundFinish date of search
Medline118/04/08
Premedline018/04/08
Embase018/04/08
Cochrane Library (except NHSEED)018/04/08
NHSEED018/04/08
Cinahl018/04/08
Psycinfo018/04/08
BNI018/04/08
EconLit018/04/08
Web of Science (SCI & SSCI)018/04/08
ISI Proceedings018/04/08
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
The Health Economics update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: In patients with suspected bone metastases in the spine, does serial imaging identify patients at risk of developing MSCC and improve outcomes (prevention of established MSCC, mobility, cost)?
Question no: 1b
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 200763602/04/07
Premedline1950 – 20072102/04/07
Embase1980 – 200750902/04/07
Cochrane Library1800 – 200786002/04/07
Cinahl1982 – 20070002/04/07
BNI1994 – 20078102/04/07
Psychinfo1967 – 20070002/04/07
SIGLE1980 – 20050003/04/07
Web of Science (SCI & SSCI)1970 – 20077851803/04/07
ISI Proceedings1990 – 200770503/04/07
Biomed Central1997 – 20077003/04/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/20085018/04/08
Premedline2007 – 04/20083118/04/08
Embase2007 – 04/200810018/04/08
Cochrane Library2007 – 04/20080018/04/08
Cinahl2007 – 04/20082018/04/08
BNI2007 – 04/20080018/04/08
Psychinfo2007 – 04/20080018/04/08
Web of Science (SCI & SSCI)2007 – 04/200866118/04/08
ISI Proceedings2007 – 04/20088118/04/08
Biomed Central2007 – 04/20085018/04/08
Total References retrieved (after de-duplication): 18 (update search: 2)
Medline search strategy (This search strategy is adapted to each database.)

Imaging AND Spinal Cord Compression
  1. Magnetic Resonance Spectroscopy/
  2. magnetic resonance.tw.
  3. MRI$1.tw.
  4. NMR$1.tw.
  5. MRS$1.tw.
  6. MRT.tw.
  7. MR imaging.tw.
  8. MR scan$.tw.
  9. MR spectroscop$.tw.
  10. (magnet$ adj3 (scan$ or imaging)).tw.
  11. (diffusion adj2 (scan$ or imaging)).tw.
  12. (functional adj2 (scan$ or imaging)).tw.
  13. exp Tomography, X-Ray Computed/
  14. (comput$ adj1 tomograph$).tw.
  15. ((ct or cat) adj (scan$ or imaging)).tw.
  16. electron beam computed tomography$.tw.
  17. 3-dimensional computerized tomography$.tw.
  18. (spiral adj CT).tw.
  19. ((multi$ slice or multi$ detector) adj CT).tw.
  20. Bone$ scintigraph$.tw.
  21. skelet$ survey$.tw.
  22. plain film$.tw.
  23. radioisotop$ bon$ scan$.tw.
  24. or/12–37
  25. serial imag$.tw.
  26. (frequenc$ adj1 imag$).tw.
  27. (frequenc$ adj1 scan$).tw.
  28. exp Sequence Analysis/
  29. or/28–31
  30. exp "Bone and Bones"/
  31. exp Bone Neoplasms/
  32. (bon$ adj metastas$).tw.
  33. exp Spinal Cord Neoplasms/
  34. exp Spinal Neoplasms/
  35. (spin$ adj metastas$).tw.
  36. or/33–38
  37. 27 and 32
  38. 40 and 39
Health Economics Literature search details

SIGN Health Economics and SCHARR Quality of Life filter added to search.
Database nameNo of references foundFinish date of search
Medline126/04/07
Premedline026/04/07
Embase026/04/07
Cochrane Library (except NHSEED)002/05/07
NHSEED002/05/07
Cinahl026/04/07
Psycinfo026/04/07
BNI026/04/07
EconLit026/04/07
Web of Science (SCI & SSCI)926/04/07
ISI Proceedings126/04/07
SIGLE026/04/07
UPDATE SEARCH
Database nameNo of references foundFinish date of search
Medline018/04/08
Premedline018/04/08
Embase018/04/08
Cochrane Library (except NHSEED)018/04/08
NHSEED018/04/08
Cinahl018/04/08
Psycinfo018/04/08
BNI018/04/08
EconLit018/04/08
Web of Science (SCI & SSCI)018/04/08
ISI Proceedings018/04/08
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
The Health Economics update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: What is the best imaging modality for diagnosis of spinal cord compression?
Question no: 4
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20062656623/10/06
Premedline1950 – 20062025/10/06
Embase1980 – 20063154024/10/06
Cochrane Library1800 – 200614325/10/06
Cinahl1982 – 20062025/10/06
BNI1994 – 20060025/10/06
Psychinfo1967 – 200610025/10/06
SIGLE1980 – 20050025/10/06
Web of Science (SCI & SSCI)1970 – 200656725/10/06
ISI Proceedings1990 – 200613325/10/06
Biomed Central1997 – 2006129025/10/06
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2006 – 04/200821318/04/08
Premedline2006 – 04/20080018/04/08
Embase2006 – 04/2008114918/04/08
Cochrane Library2006 – 04/20085118/04/08
Cinahl2006 – 04/20083018/04/08
BNI2006 – 04/20080018/04/08
Psychinfo2006 – 04/20085018/04/08
Web of Science (SCI & SSCI) and ISI Proceedings2006 – 04/200829318/04/08
Biomed Central2006 – 04/2008129018/04/08
Total References retrieved (after de-duplication): 99 (update search: 14)
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord Compression OR Paraparesis AND Diagnosis AND Metastasis AND (MRI OR CT Diagnostic Imaging)
  1. Spinal Cord Compression/
  2. (spin$ adj2 compress$).tw.
  3. (compress$ adj1 myelopath$).tw.
  4. (MSCC or MESCC).mp.
  5. or/1–4
  6. exp Paralysis/
  7. Paresthesia/
  8. exp Paraparesis/
  9. or/6–9
  10. exp Neoplasm Metastasis/
  11. metastas$.tw.
  12. (viscera$ adj metastas$).tw.
  13. (spin$ adj metastas$).tw.
  14. *Spinal Cord Neoplasms/mo, pa, pp, pc, ra, di, ri, rt, rh, ep, su, th, et, us, hi [Mortality, Pathology, Physiopathology, Prevention & Control, Radiography, Diagnosis, Radionuclide Imaging, Radiotherapy, Rehabilitation, Epidemiology, Surgery, Therapy, Etiology, Ultrasonography, History]
  15. or/11–15
  16. exp Diagnostic Imaging/
  17. (diagnos$ adj3 imag$).tw.
  18. Magnetic Resonance Spectroscopy/
  19. magnetic resonance.tw.
  20. MRI$1.tw.
  21. NMR$1.tw.
  22. MRS$1.tw.
  23. MRT.tw.
  24. MR imaging.tw.
  25. MR scan$.tw.
  26. MR spectroscop$.tw.
  27. MR elastograph$.tw.
  28. (magnet$ adj3 (scan$ or imaging)).tw.
  29. (diffusion adj2 (scan$ or imaging)).tw.
  30. (planar adj (scan$ or imaging$)).tw.
  31. (planar adj tomogra$).tw.
  32. (echoplanar adj (scan$ or imaging)).tw.
  33. zeugmatogra$.tw.
  34. MRE.tw.
  35. SPECT$1.tw.
  36. FMRI$.tw.
  37. (functional adj2 (scan$ or imaging)).tw.
  38. or/17–39
  39. exp Tomography, X-Ray Computed/
  40. (comput$ adj1 tomograph$).tw.
  41. ((ct or cat) adj (scan$ or imaging)).tw.
  42. cine-ct.tw.
  43. electron beam computed tomography$.tw.
  44. tomodensitometry$.tw.
  45. 3-dimensional computerized tomography$.tw.
  46. (spiral adj CT).tw.
  47. ((multi$ slice or multi$ detector) adj CT).tw.
  48. Bone$ scintigraph$.tw.
  49. or/41–52
  50. exp Diagnosis/
  51. exp Diagnosis, Computer-Assisted/
  52. exp "Diagnostic Techniques and Procedures"/
  53. exp "Sensitivity and Specificity"/
  54. diagnos$.tw.
  55. or/54–58
  56. (5 or 10) and 59
  57. 60 and 16
  58. 40 and 53
  59. 61 and 62
Health Economics Literature search details

SIGN Health Economics and SCHARR Quality of Life filter added to search.
Database nameNo of references foundFinish date of search
Medline1225/04/07
Premedline025/04/07
Embase4125/04/07
Cochrane Library (except NHSEED)002/05/07
NHSEED102/05/07
Cinahl025/04/07
Psycinfo025/04/07
BNI025/04/07
EconLit025/04/07
Web of Science (SCI & SSCI)725/04/07
ISI Proceedings025/04/07
SIGLE025/04/07
UPDATE SEARCH
Database nameNo of references foundFinish date of search
Medline018/04/08
Premedline018/04/08
Embase118/04/08
Cochrane Library (except NHSEED)018/04/08
NHSEED018/04/08
Cinahl018/04/08
Psycinfo018/04/08
BNI018/04/08
EconLit018/04/08
Web of Science (SCI & SSCI)018/04/08
ISI Proceedings018/04/08
Any further comments:
The update search was performed to include the years 2006–18 April 2008 only.
The Health Economics Literature update search was performed to include the years 2007–18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: What is the effectiveness of Bisphosphonates at treating spinal pain and/or preventing spinal collapse and/or spinal cord compression?
Question no: 2a
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20061548111/12/06
Premedline1950 – 2006742011/12/06
Embase1980 – 2006562011/12/06
Cochrane Library1800 – 20061091611/12/06
Cinahl1982 – 20068611/12/06
BNI1994 – 2006171011/12/06
Psychinfo1967 – 20065511/12/06
SIGLE1980 – 20050012/12/06
Web of Science (SCI & SSCI)1970 – 200647215412/12/06
ISI Proceedings1990 – 2006752412/12/06
Biomed Central1997 – 200687612/12/06
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2006 – 04/200877518/04/08
Premedline2006 – 04/200852118/04/08
Embase2006 – 04/200820118/04/08
Cochrane Library2006 – 04/200811018/04/08
Cinahl2006 – 04/20080018/04/08
BNI2006 – 04/20089018/04/08
Psychinfo2006 – 04/20085018/04/08
Web of Science (SCI & SSCI)2006 – 04/2008107318/04/08
ISI Proceedings2006 – 04/200818718/04/08
Biomed Central2006 – 04/20086018/04/08
Total References retrieved (after de-duplication): 267 (update search: 17)
Medline search strategy (This search strategy is adapted to each database.)

Vertebral Metastases AND Bisphosphonate
SR Filter added
  1. exp Spine/
  2. exp Lumbar Vertebrae/
  3. exp Thoracic Vertebrae/
  4. exp Spinal Neoplasms/
  5. exp Neoplasm Metastasis/
  6. (spin$ adj3 metasta$).tw.
  7. (vertebra$ adj3 (cancer$ or carcinoma$ or malignan$ or tumo?r$ or neoplas$ or intraepithelial$ or adeno$)).tw.
  8. vertebra$ metastas$.tw.
  9. vertebra$ collaps$.tw.
  10. spin$ collaps$.tw.
  11. exp Spinal Cord Compression/
  12. (skelet$ adj3 event$).tw.
  13. or/1–12
  14. exp Clodronic Acid/
  15. clodronat$.tw.
  16. exp Diphosphonates/
  17. Diphosphonat$.tw.
  18. bisphosphonate$.tw.
  19. zoledronat$.tw.
  20. pamidronat$.tw.
  21. Alendronat$.tw.
  22. risedronat$.tw.
  23. exp Etidronic Acid/
  24. etidronat$.tw.
  25. tiludronat$.tw.
  26. or/14–26
  27. 13 and 27
Health Economics Literature search details

SIGN Health Economics and SCHARR Quality of Life filter added to search.
Database nameNo of references foundFinish date of search
Medline3926/04/07
Premedline226/04/07
Embase7826/04/07
Cochrane Library (except NHSEED)202/05/07
NHSEED002/05/07
Cinahl2726/04/07
Psycinfo526/04/07
BNI026/04/07
EconLit026/04/07
Web of Science (SCI & SSCI)10726/04/07
ISI Proceedings2026/04/07
UPDATE SEARCH
Database nameNo of references foundFinish date of search
Medline618/04/08
Premedline218/04/08
Embase118/04/08
Cochrane Library (except NHSEED)018/04/08
NHSEED018/04/08
Cinahl018/04/08
Psycinfo018/04/08
BNI018/04/08
EconLit018/04/08
Web of Science (SCI & SSCI)1118/04/08
ISI Proceedings118/04/08
Any further comments:
The update search was performed to include the years 2006 – 18 April 2008 only.
The Health Economics update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: What is the effectiveness of Radiotherapy at treating spinal pain and/or preventing spinal collapse and/or spinal cord compression?
Question no: 2c
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 2006216518224/01/07
Premedline1950 – 2006431129/01/07
Embase1980 – 2006413210025/01/07
Cochrane Library1800 – 20068663324/01/07
Cinahl1982 – 200681429/01/07
BNI1994 – 20061129/01/07
Psychinfo1967– 20060029/01/07
SIGLE1980 – 20050029/01/07
Web of Science (SCI & SSCI)1970 – 2006193911529/01/07
ISI Proceedings1990 – 20062181129/01/07
Biomed Central1997 – 200618029/01/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2006 – 04/20085053418/04/08
Premedline2006 – 04/200836718/04/08
Embase2006 – 04/20085741218/04/08
Cochrane Library2006 – 04/200844218/04/08
Cinahl2006 – 04/200828018/04/08
BNI2006 – 04/20080018/04/08
Psychinfo2006 – 04/20080018/04/08
Web of Science (SCI & SSCI)2006 – 04/20082733218/04/08
ISI Proceedings2006 – 04/200835718/04/08
Biomed Central2006 – 04/200815018/04/08
Total References retrieved (after de-duplication): 332 (update search: 59)
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord Compression AND Radiotherapy
(RCT, SR and OS filter applied)
  1. exp Spine/
  2. exp Spinal Neoplasms/
  3. exp Neoplasm Metastasis/
  4. exp Bone Neoplasms/
  5. osseous metasta$.tw.
  6. (spin$ adj3 metasta$).tw.
  7. (vertebra$ adj3 (cancer$ or carcinoma$ or malignan$ or tumo?r$ or neoplas$ or intraepithelial$ or adeno$)).tw.
  8. vertebra$ metastas$.tw.
  9. spin$ collaps$.tw.
  10. spin$ instabil$.tw.
  11. exp Spinal Cord Compression/
  12. spin$ pain.tw.
  13. or/1–12
  14. radiotherap$.tw.
  15. (radiat$ adj2 therap$).tw.
  16. irradiat$.tw.
  17. (interstitial adj (irradiation or radiation)).tw.
  18. (radiat$ adj2 treatment$).tw.
  19. (three dimensional adj2 radiotherap$).tw.
  20. 3D radiotherap$.tw.
  21. 3DCRT.tw.
  22. external beam radiotherap$.tw.
  23. systemic radiotherap$.tw.
  24. or/14–24
Health Economics Literature search details

SIGN Health Economics and SCHARR Quality of Life filter added to search.
Database nameNo of references foundFinish date of search
Medline15026/04/07
Premedline126/04/07
Embase48226/04/07
Cochrane Library (except NHSEED)502/05/07
NHSEED602/05/07
Cinahl3826/04/07
Psycinfo026/04/07
BNI026/04/07
EconLit026/04/07
Web of Science (SCI & SSCI)12426/04/07
ISI Proceedings1126/04/07
SIGLE026/04/07
UPDATE SEARCH
Database nameNo of references foundFinish date of search
Medline118/04/08
Premedline018/04/08
Embase218/04/08
Cochrane Library (except NHSEED)018/04/08
NHSEED218/04/08
Cinahl118/04/08
Psycinfo018/04/08
BNI018/04/08
EconLit018/04/08
Web of Science (SCI & SSCI)218/04/08
ISI Proceedings018/04/08
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
The Health Economics update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: What is the effectiveness of vertebroplasty/kyphoplasty at treating spinal pain and/or preventing spinal collapse and/or spinal cord compression?
Question no: 2d
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 200784313308/02/2007
Premedline1950 – 20071062408/02/2007
Embase1980 – 20077015608/02/2007
Cochrane Library1800 – 20073122508/02/2007
Cinahl1982 – 200741208/02/2007
BNI1994 – 20073008/02/2007
Psychinfo1967– 20079208/02/2007
SIGLE1980 – 20050009/02/2007
Web of Science (SCI & SSCI)1970 – 200773912309/02/2007
ISI Proceedings1990 – 2007961009/02/2007
Biomed Central1997 – 20072109/02/2007
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/20081411318/04/08
Premedline2007 – 04/2008121218/04/08
Embase2007 – 04/2008133718/04/08
Cochrane Library2007 – 04/200848218/04/08
Cinahl2007 – 04/200815018/04/08
BNI2007 – 04/20081018/04/08
Psychinfo2007 – 04/20082118/04/08
Web of Science (SCI & SSCI)2007 – 04/2008208718/04/08
ISI Proceedings2007 – 04/200845018/04/08
Biomed Central2007 – 04/20080018/04/08
Total References retrieved (after de-duplication): 273 (update search: 28)
Medline search strategy (This search strategy is adapted to each database.)

Vertebral Metastasis AND (Vertebroplasty OR Kyphoplasty)
(RCT and SR filter applied)
  1. exp Spine/
  2. exp Lumbar Vertebrae/
  3. exp Thoracic Vertebrae/
  4. exp Spinal Neoplasms/
  5. exp Neoplasm Metastasis/
  6. (spin$ adj3 metasta$).tw.
  7. (vertebra$ adj3 (cancer$ or carcinoma$ or malignan$ or tumo?r$ or neoplas$ or intraepithelial$ or adeno$)).tw.
  8. vertebra$ metastas$.tw.
  9. vertebra$ collaps$.tw.
  10. spin$ collaps$.tw.
  11. exp Spinal Cord Compression/
  12. (skelet$ adj3 event$).tw.
  13. exp Multiple Myeloma/
  14. spin$ tumo?r$.tw.
  15. exp Back Pain/
  16. or/1–15
  17. vertebroplast$.tw.
  18. kyphoplast$.tw.
  19. exp Surgical Procedures, Minimally Invasive/mt [Methods]
  20. spin$ stabili?$.tw.
  21. (vertebra$ adj3 augment$).tw.
  22. image$ guid$ therap$.tw.
  23. nonsurgic$.tw.
  24. exp Spinal Fractures/
  25. exp Fractures, Compression/
  26. exp Polymethyl Methacrylate/
  27. PMMA.tw.
  28. or/17–27
Health Economics Literature search details

SIGN Health Economics and SCHARR Quality of Life filter added to search.
Database nameNo of references foundFinish date of search
Medline12826/04/07
Premedline526/04/07
Embase18226/04/07
Cochrane Library (except NHSEED)202/05/07
NHSEED002/05/07
Cinahl4226/04/07
Psycinfo026/04/07
BNI026/04/07
EconLit026/04/07
Web of Science (SCI & SSCI)7426/04/07
ISI Proceedings626/04/07
SIGLE026/04/07
UPDATE SEARCH
Database nameNo of references foundFinish date of search
Medline018/04/08
Premedline018/04/08
Embase218/04/08
Cochrane Library (except NHSEED)218/04/08
NHSEED018/04/08
Cinahl018/04/08
Psycinfo018/04/08
BNI018/04/08
EconLit018/04/08
Web of Science (SCI & SSCI)018/04/08
ISI Proceedings018/04/08
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
The Health Economics update search was performed to include the years 2007 –18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question no: 2f
Question title: What is the effectiveness of stabilisation surgery to prevent vertebral collapse, (where stabilisation surgery is +/
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20077495914/02/07
Premedline1950 – 200739014/02/07
Embase1980 – 20072181814/02/07
Cochrane Library1800 – 2007743414/02/07
Cinahl1982 – 200716314/02/07
BNI1994 – 20070014/02/07
Psychinfo1967 – 20071014/02/07
SIGLE1980 – 20050014/02/07
Web of Science (SCI & SSCI)1970 – 2007184610115/02/07
ISI Proceedings1990 – 2007118915/02/07
Biomed Central1997 – 2007159014/02/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/2008124818/04/08
Premedline2007 – 04/200853618/04/08
Embase2007 – 04/200843418/04/08
Cochrane Library2007 – 04/200898118/04/08
Cinahl2007 – 04/200811018/04/08
BNI2007 – 04/20080018/04/08
Psychinfo2007 – 04/20080018/04/08
SIGLE-
Web of Science (SCI & SSCI)2007 – 04/20082701418/04/08
ISI Proceedings2007 – 04/200820118/04/08
Biomed Central2007 – 04/2008152018/04/08
Total References retrieved (after de-duplication): 164 (update search: 28)
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord Compression OR Vertebral metastasis AND Stabilisation surgery
RCT and SR filters applied
  1. exp Spine/
  2. exp Spinal Neoplasms/
  3. exp Neoplasm Metastasis/
  4. (spin$ adj3 metasta$).tw.
  5. (vertebra$ adj3 (cancer$ or carcinoma$ or malignan$ or tumo?r$ or neoplas$ or intraepithelial$ or adeno$)).tw.
  6. vertebra$ metastas$.tw.
  7. vertebra$ collaps$.tw.
  8. spin$ collaps$.tw.
  9. exp Spinal Cord Compression/
  10. spin$ tumo?r$.tw.
  11. or/1–10
  12. surg$ debulk$.tw.
  13. intralesion$.tw.
  14. debulk$.tw.
  15. ((total or en bloc or radical) and (resection or removal)).tw.
  16. surg$ excision$.tw.
  17. spin$ reconstruct$.tw.
  18. posterior tumo?r remov$.tw.
  19. stabili$ surg$.tw.
  20. exp Decompression, Surgical/
  21. surg$ decompress$.tw.
  22. prevent$ surg$.tw.
  23. or/12–22
Health Economics Literature search details

SIGN Health Economics filter and SCHARR Quality of Life added to search.
Database nameNo of references foundFinish date of search
Medline6526/04/07
Premedline226/04/07
Embase4326/04/07
Cochrane Library (except NHSEED)202/05/07
NHSEED402/05/07
Cinahl2026/04/07
Psycinfo026/04/07
BNI026/04/07
EconLit026/04/07
Web of Science (SCI & SSCI)7326/04/07
ISI Proceedings626/04/07
SIGLE026/04/07
UPDATE SEARCH
Database nameNo of references foundFinish date of search
Medline018/04/08
Premedline018/04/08
Embase018/04/08
Cochrane Library (except NHSEED)018/04/08
NHSEED018/04/08
Cinahl118/04/08
Psycinfo018/04/08
BNI018/04/08
EconLit018/04/08
Web of Science (SCI & SSCI)518/04/08
ISI Proceedings018/04/08
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
The Health Economics update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: For patients with kniwn MSCC who have had surgery/radiotherapy/no treatment does ‘early’ mobilisation give better outcomes (mobility, pain) than ‘delayed’?
Question no: 14
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20073492713/03/07
Premedline1950 – 20073013/03/07
Embase1980 – 2007336914/03/07
Cochrane Library1800 – 20072113/03/07
Cinahl1982 – 200737113/03/07
BNI1994 – 20070013/03/07
Psychinfo1967 – 20071013/03/07
SIGLE1980 – 20050014/03/07
Web of Science (SCI & SSCI)1970 – 2007552214/03/07
ISI Proceedings1990 – 200728014/03/07
Biomed Central1997 – 200765014/03/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/20087018/04/08
Premedline2007 – 04/20080018/04/08
Embase2007 – 04/20080018/04/08
Cochrane Library2007 – 04/20080018/04/08
Cinahl2007 – 04/20080018/04/08
BNI2007 – 04/20080018/04/08
Psychinfo2007 – 04/20080018/04/08
Web of Science (SCI & SSCI)2007 – 04/2008131318/04/08
ISI Proceedings2007 – 04/20085018/04/08
Biomed Central2007 – 04/200858018/04/08
Total References retrieved (after de-duplication): 38 (update search: 3)
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord Compression AND Early OR Late Mobilisation
  1. Spinal Cord Compression/
  2. (spin$ adj2 compress$).tw.
  3. or/1–2
  4. neurol$ funct$.tw.
  5. neurol$ impair$.tw.
  6. exp Movement/
  7. sitting$.tw.
  8. exp Walking/
  9. spin$ blood$ flow$.tw.
  10. cord perfusion$.tw.
  11. flat$ rest$.tw.
  12. (early adj mobili$).tw.
  13. (late adj mobili$).tw.
  14. log roll$.tw.
  15. exp Postoperative Complications
  16. or/4–15
Health Economics Literature search details
A Health Economics Literature search was not required.
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: For patients with suspected/confirmed MSCC, what is the most effective steroid regime wrt preserving or improving mobility; neurology; duration of effect and toxicity?
Question no: 13
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20075947222/03/07
Premedline1950 – 20073022/03/07
Embase1980 – 20075764622/03/07
Cochrane Library1800 – 200745322/03/07
Cinahl1982 – 200721522/03/07
BNI1994 – 2007396022/03/07
Psychinfo1967– 20074022/03/07
SIGLE1980 – 20050023/03/07
Web of Science (SCI & SSCI)1970 – 20073985823/03/07
ISI Proceedings1990 – 200725223/03/07
Biomed Central1997 – 2007441123/03/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/200825418/04/08
Premedline2007 – 04/20083218/04/08
Embase2007 – 04/20081441118/04/08
Cochrane Library2007 – 04/200819118/04/08
Cinahl2007 – 04/20085218/04/08
BNI2007 – 04/200869018/04/08
Psychinfo2007 – 04/20080018/04/08
Web of Science (SCI & SSCI)2007 – 04/200848418/04/08
ISI Proceedings2007 – 04/20084218/04/08
Biomed Central2007 – 04/20088018/04/08
Total References retrieved (after de-duplication): 130 (update search: 14)
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord Compression AND Steroids
  1. Spinal Cord Compression/
  2. (spin$ adj2 compress$).tw.
  3. (spin$ adj metastas$).tw.
  4. exp Spinal Cord Neoplasms/
  5. exp Spinal Neoplasms/
  6. ((vertebra$ or spin$) adj3 (cancer$ or carcinoma$ or malignan$ or tumo?r$ or neoplas$ or intraepithelial$ or adeno$)).tw.
  7. or/1–6
  8. exp Steroids/
  9. steroid$.tw.
  10. exp Anti-Inflammatory Agents/
  11. (anti adj inflammatory agent$).tw.
  12. Dexamethason$.tw.
  13. Prednisolon$.tw.
  14. (methyl adj prednisolon$).tw.
  15. or/8–17
  16. 7 and 18
Health Economics Literature search details
A Health Economics Literature search was not required.
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: Case selection for treatment – what is the validity of Tomita and Tokuhashi scoring systems?
Question no: 6a
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 2007261114807/03/07
Premedline1950 – 200717007/03/07
Embase1980 – 200719733108/03/07
Cochrane Library1800 – 200767008/03/07
Cinahl1982 – 2007721407/03/07
BNI1994 – 20070007/03/07
Psychinfo1967 – 20070007/03/07
SIGLE1980 – 20050008/03/07
Web of Science (SCI & SSCI)1970 – 20071031608/03/07
ISI Proceedings1990 – 200775008/03/07
Biomed Central1997 – 20071353006/03/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/200832318/04/08
Premedline2007 – 04/200823218/04/08
Embase2007 – 04/20081018/04/08
Cochrane Library2007 – 04/200850118/04/08
Cinahl2007 – 04/200812718/04/08
BNI2007 – 04/20080018/04/08
Psychinfo2007 – 04/20080018/04/08
Web of Science (SCI & SSCI)2007 – 04/20081521218/04/08
ISI Proceedings2007 – 04/200811218/04/08
Biomed Central2007 – 04/200810018/04/08
Total References retrieved (after de-duplication): 118 (update search: 18)
Medline search strategy (This search strategy is adapted to each database.)

Scoring systems AND Spinal Cord Compression
  1. scor$ system$.tw.
  2. clinic$ parameter$.tw.
  3. exp Models, Statistical/
  4. evaluation$.tw.
  5. scor$ method$.tw.
  6. diagnos$ tool$.tw.
  7. exp Patient Care Planning/
  8. exp "Outcome and Process Assessment (Health Care)"/
  9. exp "Severity of Illness Index"/
  10. exp Physical Examination/
  11. exp Neurologic Examination/
  12. exp Questionnaires/
  13. exp Algorithms/
  14. symptom$ control$.tw.
  15. or/71–84
  16. exp Spinal Neoplasms/
  17. (spin$ adj (cancer$ or carcinoma$ or malignan$ or tumo?r$ or neoplas$ or intraepithelial$ or adeno$)).tw.
  18. exp Spinal Cord Compression/
  19. (skelet$ adj3 event$).tw.
  20. or/86–89
  21. 85 and 90
Health Economics Literature search details
A Health Economics Literature search was not required
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: Case selection for surgery – for patients with an established diagnosis of MSCC, what factors predict for successful outcomes (mobility, continence, lack of pain, survival) following surgery?
Question no: 6b
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20071779527/02/07
Premedline1950 – 20071027/02/07
Embase1980 – 20072434327/02/07
Cochrane Library1800 – 200725227/02/07
Cinahl1982 – 2007221527/02/07
BNI1994 – 20070027/02/07
Psychinfo1967 – 20070027/02/07
SIGLE1980 – 20050027/02/07
Web of Science (SCI & SSCI)1970 – 20076045501/03/07
ISI Proceedings1990 – 200736101/03/07
Biomed Central1997 – 200765001/03/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/200843118/04/08
Premedline2007 – 04/20083118/04/08
Embase2007 – 04/200871918/04/08
Cochrane Library2007 – 04/200814118/04/08
Cinahl2007 – 04/200814418/04/08
BNI2007 – 04/20080018/04/08
Psychinfo2007 – 04/20080018/04/08
Web of Science (SCI & SSCI)2007 – 04/2008961018/04/08
ISI Proceedings2007 – 04/20086018/04/08
Biomed Central2007 – 04/200845018/04/08
Total References retrieved (after de-duplication): 154 ; (update search: 25)
Medline search strategy (This search strategy is adapted to each database.)

MSCC AND Surgery AND Outcome (mobility, continence, lack of pain, survival)
  1. Spinal Cord Compression/
  2. (spin$ adj2 compress$).tw.
  3. (compress$ adj1 myelopath$).tw.
  4. (MSCC or MESCC).tw.
  5. (nerv$ root$ adj compress$).tw.
  6. vertebra$ collaps$.tw.
  7. spin$ collaps$.tw.
  8. or/1–7
  9. surg$ debulk$.tw.
  10. intralesion$.tw.
  11. debulk$.tw.
  12. ((total or en bloc or radical) and (resection or removal)).tw.
  13. surg$ excision$.tw.
  14. spin$ reconstruct$.tw.
  15. posterior tumo?r remov$.tw.
  16. stabili$ surg$.tw.
  17. exp Decompression, Surgical/
  18. surg$ decompress$.tw.
  19. or/9–18
  20. 8 and 19
  21. exp Fecal Incontinence/or exp Urinary Incontinence/
  22. exp Back Pain/or exp Low Back Pain/
  23. Karnofsky performance index$.tw.
  24. surviv$.tw.
  25. exp Morbidity/
  26. exp Motor Skills/
  27. mobili$.tw.
  28. exp Prognosis/hi, sn, is, mt [History, Statistics & Numerical Data, Instrumentation, Methods]
  29. prognos$.tw.
  30. or/21–29
  31. 20 and 30
Health Economics Literature search details
A Health Economics Literature search was not required
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: Case selection for radiotherapy - for patients with an established diagnosis of MSCC, what factors predict for successful outcomes (mobility, continence, lack of pain, survival) following radiotherapy?
Question no: 6c
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20072716705/03/07
Premedline1950 – 20075105/03/07
Embase1980 – 20073135506/03/07
Cochrane Library1800 – 20075205/03/07
Cinahl1982 – 200717005/03/07
BNI1994 – 20070005/03/07
Psychinfo1967 – 20071005/03/07
SIGLE1980 – 20050006/03/07
Web of Science (SCI & SSCI)1970 – 20073543806/03/07
ISI Proceedings1990 – 200721006/03/07
Biomed Central1997 – 2007155006/03/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/200839518/04/08
Premedline2007 – 04/20084218/04/08
Embase2007 – 04/2008741218/04/08
Cochrane Library2007 – 04/20082018/04/08
Cinahl2007 – 04/200810018/04/08
BNI2007 – 0420080018/04/08
Psychinfo2007 – 04/20080018/04/08
Web of Science (SCI & SSCI)2007 – 04/200876218/04/08
ISI Proceedings2007 – 04/20086018/04/08
Biomed Central2007 – 04/200843018/04/08
Total References retrieved (after de-duplication): 117 (update search: 16)
Medline search strategy (This search strategy is adapted to each database.)

MSCC AND Radiotherapy AND Incontinence (or motor skills or prognosis)
  1. Spinal Cord Compression/
  2. (spin$ adj2 compress$).tw.
  3. (compress$ adj1 myelopath$).tw.
  4. (MSCC or MESCC).tw.
  5. (nerv$ root$ adj compress$).tw.
  6. vertebra$ collaps$.tw.
  7. spin$ collaps$.tw.
  8. or/1–7
  9. exp Fecal Incontinence/or exp Urinary Incontinence/
  10. exp Back Pain/or exp Low Back Pain/
  11. Karnofsky performance index$.tw.
  12. surviv$.tw.
  13. exp Morbidity/
  14. exp Motor Skills/
  15. mobili$.tw.
  16. exp Prognosis/hi, sn, is, mt [History, Statistics & Numerical Data, Instrumentation, Methods]
  17. prognos$.tw.
  18. or/9–17
  19. radiotherap$.tw.
  20. (radiat$ adj2 therap$).tw.
  21. irradiat$.tw.
  22. (interstitial adj (irradiation or radiation)).tw.
  23. (radiat$ adj2 treatment$).tw.
  24. (three dimensional adj2 radiotherap$).tw.
  25. 3D radiotherap$.tw.
  26. 3DCRT.tw.
  27. external beam radiotherap$.tw.
  28. systemic radiotherap$.tw.
  29. or/19–29
  30. 8 and 30
  31. 31 and 18
Health Economics Literature search details
A Heath Economics Literature search was not required.
Any further comments:
The update search was performed to include the years 2007–18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: What surgical technique is the most effective in treating patients with known MSCC in terms of outcomes outlined in PICO?
Question no: 8
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20071827104/04/07
Premedline1950 – 200716404/04/07
Embase1980 – 2007992404/04/07
Cochrane Library1800 – 200777104/04/07
Cinahl1982 – 20074404/04/07
BNI1994 – 20070004/04/07
Psychinfo1967 – 20071004/04/07
SIGLE1980 – 20050016/04/07
Web of Science (SCI & SSCI)1970 – 20079356016/04/07
ISI Proceedings1990 – 200730304/04/07
Biomed Central1997 – 200748004/04/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/200819318/04/08
Premedline2007 – 04/200812218/04/08
Embase2007 – 04/200811418/04/08
Cochrane Library2007 – 04/200821218/04/08
Cinahl2007 – 04/20083318/04/08
BNI2007 – 04/20080018/04/08
Psychinfo2007 – 04/20080018/04/08
Web of Science (SCI & SSCI)2007 – 04/2008106618/04/08
ISI Proceedings2007 – 04/20084018/04/08
Biomed Central2007 – 04/200824018/04/08
Total References retrieved (after de-duplication): 173 (update search: 15)
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord compression AND Laminectomy And (RCT AND SR filters)
  1. exp Spinal Cord Compression/su [Surgery]
  2. (spin$ adj2 compress$).tw.
  3. (compress$ adj1 myelopath$).tw.
  4. (MSCC or MESCC).tw.
  5. (nerv$ root$ adj compress$).tw.
  6. vertebra$ collaps$.tw.
  7. spin$ collaps$.tw.
  8. or/1–7
  9. surg$ debulk$.tw.
  10. intralesion$.tw.
  11. debulk$.tw.
  12. ((total or en bloc or radical) and (resection or removal)).tw.
  13. surg$ excision$.tw.
  14. spin$ reconstruct$.tw.
  15. posterior tumo?r remov$.tw.
  16. stabili$ surg$.tw.
  17. exp Decompression, Surgical/
  18. surg$ decompress$.tw.
  19. lamin$.tw.
  20. exp Spinal Fusion/
  21. anterior$ surger$.tw.
  22. corporectom$.tw.
  23. exp Endoscopy/
  24. endoscop$ surgical$ procedure$.tw.
  25. vertebroplast$.tw.
  26. or/9–26
  27. 8 and 27
Health Economics Literature search details

SIGN Health Economics filter and SCHARR Quality of Life filter added to search.
Database nameNo of references foundFinish date of search
Medline2825/04/07
Premedline025/04/07
Embase1625/04/07
Cochrane Library (except NHSEED)025/04/07
NHSEED025/04/07
Cinahl1025/04/07
Psycinfo025/04/07
BNI025/04/07
EconLit025/04/07
Web of Science (SCI & SSCI)2925/04/07
ISI Proceedings125/04/07
SIGLE025/04/07
UPDATE SEARCH
Database nameNo of references foundFinish date of search
Medline018/04/08
Premedline018/04/08
Embase018/04/08
Cochrane Library (except NHSEED)018/04/08
NHSEED018/04/08
Cinahl018/04/08
Psycinfo018/04/08
BNI018/04/08
EconLit018/04/08
Web of Science (SCI & SSCI)218/04/08
ISI Proceedings018/04/08
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
The Health Economics update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: In patients with known MSCC referred for radiotherapy, what is the most effective and cost effective dose fractionation regimen?
Question no: 9
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 200784212918/04/07
Premedline1950 – 200716418/04/07
Embase1980 – 20079169218/04/07
Cochrane Library1800 – 200738518/04/07
Cinahl1982 – 200746418/04/07
BNI1994 – 20071018/04/07
Psychinfo1967 – 200710218/04/07
SIGLE1980 – 20050019/04/07
Web of Science (SCI & SSCI)1970 – 20077735919/04/07
ISI Proceedings1990 – 2007631818/04/07
Biomed Central1997 – 200746118/04/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/200818218/04/08
Premedline2007 – 04/200815218/04/08
Embase2007 – 04/200821518/04/08
Cochrane Library2007 – 04/200813218/04/08
Cinahl2007 – 04/200814218/04/08
BNI2007 – 04/20080018/04/08
Psychinfo2007 – 04/20080018/04/08
Web of Science (SCI & SSCI)2007 – 04/20081021918/04/08
ISI Proceedings2007 – 04/200813518/04/08
Biomed Central2007 – 04/200821018/04/08
Total References retrieved (after de-duplication): 191 (update search: 26)
Medline search strategy (This search strategy is adapted to each database.)

Radiotherapy/Dose fractionation AND MSCC
RCT and SR filters applied
  1. radiotherap$.tw.
  2. (radiat$ adj2 therap$).tw.
  3. irradiat$.tw.
  4. (interstitial adj (irradiation or radiation)).tw.
  5. (radiat$ adj2 treatment$).tw.
  6. (three dimensional adj2 radiotherap$).tw.
  7. 3D radiotherap$.tw.
  8. 3DCRT.tw.
  9. external beam radiotherap$.tw.
  10. systemic radiotherap$.tw.
  11. exp Radiosurgery/
  12. LINAC$.tw.
  13. IMRT$.tw.
  14. exp Radiotherapy Planning, Computer-Assisted/
  15. exp Radiotherapy Dosage/
  16. intensity-modulated radiation therap$.tw.
  17. exp Dose Fractionation/
  18. (dose$ or dosage$).tw.
  19. or/1–19
  20. Spinal Cord Compression/
  21. (spin$ adj2 compress$).tw.
  22. (compress$ adj1 myelopath$).tw.
  23. (MSCC or MESCC).tw.
  24. or/21–24
  25. 20 and 25
Health Economics Literature search details
A Health Economics Literature search was not required.
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: What is the most effective bladder and bowel management for patients with spinal cord injury (MSCC)?
Question no: 11b
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20072898119/07/07
Premedline1950 – 2007643120/07/07
Embase1980 – 20071594520/07/07
Cochrane Library1800 – 20072174520/07/07
Cinahl1982 – 2007191020/07/07
BNI1994 – 2007281220/07/07
Psychinfo1967 – 20078120/07/07
SIGLE1980 – 20053224/07/07
Web of Science (+ ISI Proc.)1970 – 20071135824/07/07
Biomed Central1990 – 200721224/07/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/2008121018/04/08
Premedline2007 – 04/200827618/04/08
Embase2007 – 04/2008181018/04/08
Cochrane Library2007 – 04/200839118/04/08
Cinahl2007 – 04/20081018/04/08
BNI2007 – 04/20087218/04/08
Psychinfo2007 – 04/20080018/04/08
Web of Science (SCI & SSCI) and ISI Proceedings2007 – 04/200815418/04/08
Biomed Central2007 – 04/20084018/04/08
Total References retrieved (after de-duplication): 222 (update search: 23)
Medline search strategy (This search strategy is adapted to each database.)

(Bladder management OR Incontinence) AND (Spinal Cord Compression OR Spinal Injury)
  1. bladder management$.tw.
  2. exp Urinary Bladder, Neurogenic/
  3. exp Urinary Retention/
  4. exp Urination Disorders/
  5. urin$ retention$.tw.
  6. incomplete bladder empty$.tw.
  7. exp Urinary Incontinence/
  8. detrusor$.tw.
  9. overactive bladder$.tw.
  10. detrusor$ overactiv$.tw.
  11. exp Urinary Catheterization/
  12. or/1–11
  13. Spinal Cord Compression/
  14. (spin$ adj2 compress$).tw.
  15. exp Spinal Cord Injuries/co, pp, di, rh, th [Complications, Physiopathology, Diagnosis, Rehabilitation, Therapy]
  16. Cord injur$.tw.
  17. exp Cauda Equina/ab, pp, in [Abnormalities, Physiopathology, Injuries]
  18. Spin$ Injur$.tw.
  19. upper motor neuron.mp.
  20. or/13–19
  21. 12 and 20
  22. exp Muscarinic Antagonists/ad, ae, ct, tu, to, ur [Administration & Dosage, Adverse Effects, Contraindications, Therapeutic Use, Toxicity, Urine]
  23. 21 and 22
  24. anticholinergic$.tw.
  25. 24 and 21
  26. reflex voiding$.tw.
  27. 26 and 21
  28. 21 or 23 or 25 or 27
Health Economics Literature search details
A Health Economics Literature search was not required.
Any further comments:
The update search was performed to include the years 2007–18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: What is the most effective pressure ulcer management for patients with spinal cord injury (MSCC)?
Question no: 11b
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20074743820/03/07
Premedline1950 – 200719021/03/07
Embase1980 – 20072542420/03/07
Cochrane Library1800 – 200796621/03/07
Cinahl1982 – 2007651421/03/07
BNI1994 – 20073383520/03/07
Psychinfo1967 – 20078221/03/07
SIGLE1980 – 20051121/03/07
Web of Science (SCI & SSCI)1970 – 20073931821/03/07
ISI Proceedings1990 – 200733221/03/07
Biomed Central1997 – 200794021/03/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/200830318/04/08
Premedline2007 – 04/200814318/04/08
Embase2007 – 04/200840518/04/08
Cochrane Library2007 – 04/20088118/04/08
Cinahl2007 – 04/20083018/04/08
BNI2007 – 04/200852218/04/08
Psychinfo2007 – 04/20081018/04/08
Web of Science (SCI & SSCI)2007 – 04/20089118/04/08
ISI Proceedings2007 – 04/20083218/04/08
Biomed Central2007 – 04/20080018/04/08
Total References retrieved (after de-duplication): 98 (update search: 11)
Medline search strategy (This search strategy is adapted to each database.)

Pressure Sore AND Spinal Cord Compression
1.

exp Skin/

2.

exp Skin Care/

3.

exp Tissues/

4.

exp Pressure Ulcer/co, di, pc, th [Complications, Diagnosis, Prevention & Control, Therapy]

5.

(bed adj1 sore$).tw.

6.

pressure$ sore$.tw.

7.

exp Tissue Survival/

8.

tissue$ viabilit$ assessment$.tw.

9.

or/1–8

10.

exp Technology Assessment, Biomedical/

11.

exp Equipment Design/

12.

exp Therapeutics/

13.

exp Treatment Outcome/

14.

or/10–13

15.

Spinal Cord Compression/

16.

(spin$ adj2 compress$).tw.

17.

or/15–16

18.

9 and 14 and 17

19.

from 18 keep 29

20.

9 and 17

21.

bladder management$.tw.

22.

bowel management$.tw.

23.

exp Urinary Bladder, Neurogenic/

24.

exp Rehabilitation/

25.

exp Patient Education/

26.

or/21–25

30.

26 and 17

31.

thromboprophylax$.tw.

32.

exp Thrombosis/pc [Prevention & Control]

33.

31 or 32

34.

33 and 17

35.

emotion$ support$.tw.

36.

psychol$ support$.tw.

37.

exp Family/

38.

exp Counseling/

39.

or/35–38

40.

39 and 17

41.

exp Hospitals, Special/

42.

41 and 17

43.

exp Hospitals, General/

44.

43 and 17

45.

exp Hospices/

46.

45 and 17

47.

exp Primary Health Care/

48.

46 and 17

49.

exp Residential Facilities/or exp Home Care Services/or exp Nursing Homes/or exp Homes for the Aged/or exp Health Services for the Aged/

50.

49 and 17

51.

mobilit$.tw.

52.

61 and 17

53.

circulatory function$.tw.

54.

53 and 17

55.

respiratory function$.tw.

56.

55 and 17

Health Economics Literature search details
A Health Economics Literature Search was not required.
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: What is the most effective respiratory and circulatory management for patients with spinal cord injury (MSCC)?
Question no: 11b
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20072013323/10/07
Premedline1950 – 200797423/10/07
Embase1980 – 20073002523/10/07
Cochrane Library1800 – 20077024/10/07
Cinahl1982 – 20071821423/10/07
BNI1994 – 20070023/10/07
Psychinfo1967 – 20071023/10/07
SIGLE1980 – 20050024/10/07
Web of Science (SCI & SSCI) and ISI Proceedings1970 – 2007
1990– 2007
52724/10/07
Biomed Central1997 – 20078024/10/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/200840518/04/08
Premedline2007 – 04/20086018/04/08
Embase2007 – 04/200859518/04/08
Cochrane Library2007 – 04/20083018/04/08
Cinahl2007 – 04/20085118/04/08
BNI2007 – 04/20080018/04/08
Psychinfo2007 – 04/20081018/04/08
Web of Science (SCI & SSCI)2007 – 04/20088018/04/08
ISI Proceedings2007 – 04/20083018/04/08
Biomed Central2007 – 04/20080018/04/08
Total References retrieved (after de-duplication): 69 (update search: 10)
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord Compression (or Spinal Injury) OR Hypotension AND Bandages or Stockings OR Blood Circulation
RCT and SR filters applied
1.

Spinal Cord Compression/

2.

(spin$ adj2 compress$).tw.

3.

(compress$ adj1 myelopath$).tw.

4.

(MSCC or MESCC).tw.

5.

or/1–4

6.

exp Hypotension, Orthostatic/

7.

postur$ hypotens$.tw.

8.

exp Autonomic Nervous System Diseases/

9.

exp Blood Pressure/

10.

exp Blood Flow Velocity/

11.

exp Lower Body Negative Pressure/

12.

hypertention.mp.

13.

or/6–12

14.

exp Bandages/

15.

TED stocking$.tw.

16.

Abdominal binder$.tw.

17.

exp Ephedrine/

18.

exp Fludrocortisone/

19.

lower limb compression bandaging$.tw.

20.

exp Leg/

21.

or/14–20

22.

13 or 21

23.

5 and 22

82.

exp Spinal Cord Injuries/

83.

82 and 13

84.

83 and 21

88.

exp "Range of Motion, Articular"/

89.

exp Lower Extremity/

90.

exp Leg/

91.

exp Movement/and exp Muscles/

92.

exp Mobility Limitation/

93.

mobilit$.tw.

94.

or/88–93

95.

exp Blood Circulation/

96.

exp Venous Thrombosis/pc [Prevention & Control]

97.

deep vein thrombosi$.tw.

98.

muscle length.mp.

99.

or/95–98

100.

94 or 99

101.

5 and 100

Health Economics Literature search details
A Health Economics Literature search was not required.
Any further comments:
The search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: Given that specialised centres for patients with spinal injuries (or specialised wards for neuro-patients) exist and provide services that benefit patients; can MSCC patients also benefit from these kinds of services (wards/centres)?
Question no: 16a
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 20071703523/04/07
Premedline1950 – 200712024/04/07
Embase1980 – 20072331324/04/07
Cochrane Library1800 – 2007114024/04/07
Cinahl1982 – 200762724/04/07
BNI1994 – 20071024/04/07
Psychinfo1967 – 20075024/04/07
SIGLE1980 – 20050024/04/07
Web of Science (SCI & SSCI)1970 – 2007416324/04/07
ISI Proceedings1990 – 20073024/04/07
Biomed Central1997 – 200771024/04/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 04/200812218/04/08
Premedline2007 – 04/20089218/04/08
Embase2007 – 04/200838618/04/08
Cochrane Library2007 – 04/200824018/04/08
Cinahl2007 – 04/20084218/04/08
BNI2007 – 04/20080018/04/08
Psychinfo2007 – 04/20087018/04/08
Web of Science (SCI & SSCI)2007 – 04/200814518/04/08
ISI Proceedings2007 – 04/20082118/04/08
Biomed Central2007 – 04/200831018/04/08
Total References retrieved (after de-duplication): 44 (update search: 12)
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord Compression AND Rehabilitation Centres or Spinal Injury or Referral
  1. Spinal Cord Compression/
  2. (spin$ adj2 compress$).tw.
  3. (compress$ adj1 myelopath$).tw.
  4. (MSCC or MESCC).tw.
  5. or/1–4
  6. exp Spinal Cord Injuries/rh [Rehabilitation]
  7. exp Spinal Injuries/rh [Rehabilitation]
  8. exp Rehabilitation/
  9. exp Rehabilitation Centers/
  10. rehab$.tw.
  11. (neuro adj rehab$).tw.
  12. special$ ward$.tw.
  13. exp "Referral and Consultation"/
  14. spin$ injur$ rehab$ centre$.tw.
  15. or/6–14
  16. 5 and 15
Health Economics Literature search details
A Health Economics Literature search was not required.
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
NATIONAL COLLABORATING CENTRE FOR CANCER
Clinical Guideline
Metastatic Spinal Cord Compression
Literature search summary
Question title: Which MSCC patient factors will predict for beneficial outcomes from specialised services?
Question no: 16b
Literature search details
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline1950 – 2007591124/04/07
Premedline1950 – 200711025/04/07
Embase1980 – 2007124825/04/07
Cochrane Library1800 – 20070025/04/07
Cinahl1982 – 200722225/04/07
BNI1994 – 20070025/04/07
Psychinfo1967 – 20073025/04/07
SIGLE1980 – 20050025/04/07
Web of Science (SCI & SSCI)1970 – 200740325/04/07
ISI Proceedings1990 – 20073025/04/07
Biomed Central1997 – 200721025/04/07
UPDATE SEARCH
Database nameDates CoveredNo of references foundNo of references retrievedFinish date of search
Medline2007 – 43/20083118/04/08
Premedline2007 – 04/20086018/04/08
Embase2007 – 04/200818418/04/08
Cochrane Library2007 – 04/20080018/04/08
Cinahl2007 – 04/20082118/04/08
BNI2007 – 04/20080018/04/08
Psychinfo2007 – 04/20082018/04/08
Web of Science (SCI & SSCI)2007 – 04/20086318/04/08
ISI Proceedings2007 – 04/20081118/04/08
Biomed Central2007 – 04/200811018/04/08
Total References retrieved (after de-duplication): 3 (update search: 1)
Medline search strategy (This search strategy is adapted to each database.)

Spinal Cord compression AND Spinal Injuries rehabilitation centres OR referral
  1. Spinal Cord Compression/
  2. (spin$ adj2 compress$).tw.
  3. (compress$ adj1 myelopath$).tw.
  4. (MSCC or MESCC).tw.
  5. or/1–4
  6. exp Spinal Cord Injuries/rh [Rehabilitation]
  7. exp Spinal Injuries/rh [Rehabilitation]
  8. special$ ward$.tw.
  9. exp "Referral and Consultation"/
  10. spin$ injur$ rehab$ centre$.tw.
  11. or/6–10
  12. 5 and 11
Health Economics Literature search details
A Health Economics Literature search was not required.
Any further comments:
The update search was performed to include the years 2007 – 18 April 2008 only.
Copyright © 2008, National Collaborating Centre for Cancer.

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