Figure 2. The Cfr methyltransferase confers PhLOPSa resistance by methylating A2503 at the C8 position.

Figure 2

The Cfr methyltransferase confers PhLOPSa resistance by methylating A2503 at the C8 position. The panels are described from left to right. A schematic bacterial cell is depicted with a translating ribosome. The structure of the bacterial 50S ribosomal subunit70 and an expanded view with the structures of four drugs73 - 75 (depicted in stick representation) bound at the peptidyl transferase center are shown. The antibiotics are chloramphenicol (light gray), clindamycin (very dark gray), dalfopristin (very light gray) and tiamulin (dark gray). The A2503 target of the Cfr methyltransferase is shown as a darker area. The chemical structure of m2m8A is shown. A color version of this image is available at www.landesbioscience.com/curie.

From: Antibiotic Resistance in Bacteria Caused by Modified Nucleosides in 23S Ribosomal RNA

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