Figure 2. Proposed mechanistic differences between normal and premature termination.

Figure 2

Proposed mechanistic differences between normal and premature termination. Normal termination is thought to be highly efficient and involve interactions between Pab1p (green ovals) and ribosome-associated Sup35p. Premature termination is thought to be inefficient, and the absence of proximal Pab1p is hypothesized to facilitate binding of the Upf/Nmd factors to the termination complex, thereby leading to peptide hydrolysis, 60S ribosomal subunit release, and Upf1p recruitment/stimulation of the Dcp1p/Dcp2p decapping complex. 1, Upf1p; 2, Nmd2p; 3, Upf3p; 35, Sup35p; 45, Sup45p. A color version of this figure is available online at www.Eurekah.com.

From: All Termination Events Are Not Equal: Premature Termination in Yeast Is Aberrant and Triggers NMD

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