Figure 4. Schematic of RNA structures required for amber/W site editing in HDV genotypes I and III.

Figure 4

Schematic of RNA structures required for amber/W site editing in HDV genotypes I and III. The location of the amber/W site is indicated by the star. Sequences involved in forming the base-paired secondary structure essential for editing are indicated by diagonal hashes. In the genotype I unbranched rod structure these sequences are correctly positioned to form the structure required for editing,20 while in genotype III they are not.45 For genotype III the structure required for editing contains two ca. 25 nt stem-loops and deviates from the unbranched rod by about 80 base-pairs. The vertical arrows indicate that the distribution of the genotype III RNA between these two structures favors the unbranched rod structure.45,54 Editing levels in HDV genotype III are restricted by this distribution. The three double-stranded RNA binding domains in ADAR1 are indicated by striped bars.

From: Hepatitis Delta Virus RNA Editing

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