Figure 3. Structures of HMG box/DNA complexes (stereo pairs).

Figure 3

Structures of HMG box/DNA complexes (stereo pairs). A) SRY-DNA complex34 (protein databank accession code 1J46). Ribbon model of protein is shown in green (HMG box) and red (tail; residues 70-85 in the HMG-box consensus). DNA is shown as gray sticks. B) LEF-1-DNA complex14 (protein databank accession code 2LEF). Ribbon model of protein is shown in blue (HMG box) and red (tail; residues 70-85). DNA is shown as gray sticks. Asterisk (right panel) indicates binding of LEF-1 tail within compressed major groove. Cantilever side chains I13 (SRY) and M13 (LEF-1; M11 in protein data bank (PDB) entry) are shown as black sticks.

From: Molecular Mechanisms of Male Sex Determination: The Enigma of SRY

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