Figure 3. Possible roles of curved DNA in eukaryotic transcription.

Figure 3

Possible roles of curved DNA in eukaryotic transcription. (I) Transcription factors may recognize the curved shape of DNA. (II) Curved DNA can juxtapose two distant sites on a sequence. For example, factors bound upstream can be brought close to the basal machinery. (III) Transcription factor binding may induce a change in the curved conformation, which in turn regulates transcription. (IV) Curved DNA could regulate nucleosome positioning.

From: Curved DNA and Transcription in Eukaryotes

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