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Figure 7. Model of blood coagulation.

Figure 7Model of blood coagulation

The initiation of coagulation occurs with the formation of the tissue factor-factor VIIa complex (TF-VIIa). The intrinsic pathway is triggered when thrombin (IIa) is generated leading to the activation of factor XI. More thrombin will be generated which is important for the activation of TAFI. TAFIa inhibits fibrinolysis and thereby protects the fibrin clot. Abbreviations used: TM indicates thrombomodulin, uninterrupted line indicates activation, interrupted line inhibition. (Modified from Bouma et al. Thromb Haemostas 1998; 80:24)

From: Factor XI, TAFI and DIC

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