Table 4. Recommended treatment regimen for late latent syphilis

Recommended regimen:

  • Benzathine penicillin G: 2.4 million units IM (1.2 mu in each buttock) given weekly for 3 weeks
Treatment for the penicillin-allergic patient who has no evidence of CNS syphilis and is not pregnant:
  • Doxycycline 100 mg by mouth twice daily for 28 days

From: Chapter 10 - Syphilis

Cover of Screening for Infectious Diseases Among Substance Abusers
Screening for Infectious Diseases Among Substance Abusers.
Treatment Improvement Protocol (TIP) Series, No. 6.
Center for Substance Abuse Treatment.

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