Figure 2. Genetic control of dorsal-ventral polarity and Snail expression.

Figure 2

Genetic control of dorsal-ventral polarity and Snail expression. A maternal cascade, constituted of Toll receptor and other components including the adaptor Tube and the kinase Pelle, regulates Dorsal nuclear translocation. High levels of Dorsal protein in the ventral nuclei directly activate Twist and Snail. Dorsal cooperates with Twist for optimal expression of Snail in the cells of the presumptive mesoderm. Snail then represses downstream target genes to define the mesoderm territory.

From: Change of Epithelial Fate: Lessons from Gastrulation in Drosophila

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