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Figure 2. Processing sites on antigenomic RNA.

Figure 2

Processing sites on antigenomic RNA. Shown in the upper half is an antigenomic RNA transcript that has initiated at what becomes the 5'-end of the mRNA species. This transcript is shown to have elongated to what would correspond to about 1.5-times around a circular genomic RNA template. Shown in the lower half are two RNAs that could be processed from such a transcript. First is poly(A)-processing to produce the mRNA for δAg. Second, is ribozyme cleavage followed by ligation, to produce unit-length circular antigenomic RNA. As discussed in the text, it is now considered possible that these two processing pathways are largely mutually exclusive.

From: Structure and Replication of Hepatitis Delta Virus RNA

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