Partial List of Medications Metabolized by Cytochrome P450 3A4

Inhibitors (potentially increasing blood levels of buprenorphine)SubstratesInducers (potentially decreasing blood levels of buprenorphine)
Amiodarone Clarithromycin Delavirdine Erythromycin Fluconazole Fluoxetine Fluvoxamine Grapefruit Juice Indinavir Itraconazole Ketoconazole Metronidazole Miconazole Nefazadone Nelfinavir Nicardipine Norfloxacin Omeprozol Paroxetine Ritonavir Saquinavir Sertraline Verapamil Zafirlukast ZileutonAlprazolam Amlodipine Astemizole Atorvastatin Carbamazepine Cisapride Clindamycin Clonazepam Cyclobenzaprine Cyclosporine Dapsone Delavirdine Dexamethasone Diazepam Diltiazem Disopyramide Doxorubicin Erythromycin Estrogens Etoposide Felodipine Fentanyl Fexofenadine Glyburide Ifosfamide Indinavir Ketoconazole Lansoprazole LidocaineLoratadine Losartan Lovastatin Miconazole Midazolam Navelbine Nefazadone Nelfinavir Nicardipine Nifedipine Nimodipine Ondansetron Oral Contraceptives Paclitaxel Prednisone Progestins Quinidine Rifampin Ritonavir R‐Warfarin Saquinavir Sertraline Simvastatin Tacrolimus Tamoxifen Verapamil Vinblastine ZileutonCarbamazepine Dexamethasone Efavirenz Ethosuximide Nevirapine Phenobarbital Phenytoin Primadone Rifampin

For a continuously updated list of cytochrome P450 3A4 drug interactions, visit http://medicine​.iupui​.edu/flockhart/table.htm.

From: 2 Pharmacology

Cover of Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction
Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction.
Treatment Improvement Protocol (TIP) Series, No. 40.
Center for Substance Abuse Treatment.

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