Figure 3. Schematic of the structure of PABP and its interaction partners.

Figure 3

Schematic of the structure of PABP and its interaction partners. The N-terminal part of PABP consists of 4 RRMs, while the PABC domain resides at the C-terminus. The arrows indicate experimentally verified interactions to the binding partners shown while the hatched line symbolizes more generally a connection that has been suggested with other processes in mRNA metabolism. eIF4G and poly(A) can bind simultaneously to RRM1 and -2 while the available evidence suggests that only one partner can bind to the PABC at any given time. Paip2 was shown to interact with RRM2 and RRM3 of PABP as well as with the PABC domain. Paip2 forms complexes of 2:1 stochiometry with PABP in vitro and there are indications that it competes directly with Paip1 for the same binding regions of PABP.36,74 Paip2 binding to RRM2 and RRM3 of PABP can disrupt the binding of PABP to poly(A) and it interferes with poly(A)-dependent translation. The inhibitory effects of Paip2 are indicated by lines with a vertical bar at the end. Adapted with permission from: Preiss T. BIOspektrum 2001; 4:315-319. © 2001 Spektrum Akademischer Verlag

From: The End in Sight: Poly(A), Translation and mRNA Stability in Eukaryotes

Cover of Madame Curie Bioscience Database
Madame Curie Bioscience Database [Internet].
Austin (TX): Landes Bioscience; 2000-2013.
Copyright © 2000-2013, Landes Bioscience.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.