Table 9. Bone mineral density in chronic renal failure measured by single-photon absorptiometry and radiographic absorptiometrya

ReferenceStudy design/gfollowupNo. of patientsSiteResults: Excess cumulative bone loss compared with age- and sex-matched controls
Catto(155) 1973Longitudinal/g 6 mo13Distal radius3.8% (mean)
Griffiths(156) 1977Longitudinal/g 2-5 yr195Radius and ulna>= 4 SD
Hruska(157) 1978Retrospective46Mid- and distal radius>= 2 SD (mean)
Lindergard(158) 1981Longitudinal/g 15-39 mo74Midshaft radius0.84 ± 1.20 SD
Seeman(159) 1982Retrospective14Midradius1.15 SD (increased)b
Muirhead(154) 1983Retrospective64Femoral shaft>= 1 SD
Rickers(161) 1983Longitudinal/g 3 yr31Distal radius9%
Buccianti(160) 1984Longitudinal/g 1 yr12Radius and ulna10%
Colbert(162) 1984Longitudinalb case control/g2 yr355Phalangeal bones1.6%-3.3%
Gupta(163) 1984Longitudinal/g13 mo (avg)8Distal radius7%

a SPA was used in all studies but that of Colbert.(162)

b BMD at the mid-radius was significantly (P <= 0.05) increased.

Abbreviations: RA = radiographic absorptiometry; SD = standard deviation; SPA = single-photon absorptiometry.

From: Bone Densitometry: Patients with End-Stage Renal Disease

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