Table 2. Case series published from 1985-1996 that measured the ability of signal-averaged electrocardiography to predict sudden death or ventricular tachyarrhythmias after acute myocardial infarction

Preference No. of patients Device Parameters defining VLP
dQRSa RMS40b LAS40c
Definition of +SAECG Se (%) Sp (%) +PV (%) -PV (%) Mean followup days (range) End-pointsd (%) No. +SAECG (%) during followup
Ahuja(41)262ART 1200 EPX+RMS40NSNS.15.98315±7417/262 (7)36/262 (14)
Breithardt(20)

132Princeton signal average No. 4202+LAS40.66.60.23.90450±3309/132 (7)59/132 (45)
Brembilla-Perrot(42)328LP 3000 (Cardionics)++Any 1 parameterNSNSNSNS1,034±79416/328 (5)151/328 (46)
Cripps(43)176ART 101+++Any 1 parameter.82.81.22.99450±210 (90-720)11/176 (6)41/176 (23)
de Chillou(44)114MAC 12/15+++Any 2 parametersNSNSNSNS330±90 (180-540)25/114 (22)26/114 (23)
Denes(45)787ART 1200 or Corozonix Predictor+++dQRSNSNSNSNS300±9092/787 (12)97/787 (12)
Denniss(46)306DEC 11/34 computer (Fortran (program)+dQRS.66.78.24.9636043/306 (14)80/306 (26)
Do(47)90Corozonix Predictor+++All 3 parameters1.0.78.161.0NSNS26/90 (29)
El-Sherif(34)156ART 1200 EPX++dQRS, or RMS40.35.79.38.76 (0-365)20/156 (13)81/156 (52)
El Sherif(48)1,158ART 1200 EXP or Corozonix Predictor+++dQRS, or RMS40.48.90.17.98310±96 (0-365)45/114 (40)139/158 (12)
Farrell(49)416ART 1200 EPX+++Any 2 parameters.63.81.17.81612 (1-1,112)47/416 (11)89/418 (21)
Gomes(50)115ART 101+++Any 1 parameter.63.84.38.93420±24016/115 (14)51/115 (44)
Gomes(51)102ART 101+++Any 1 parameter.75.60.24.94360±18015/102 (15)30/102 (29)
Hohnloser(52)173NS+++Any 2 parameters.56.78.12.97360±1509/173 (5)41/173 (24)
Kuchar(53)210ART++LAS40 or dQRSNS.65.17NS220 (median) (180-720)15/210 (7)78/210 (37)
Mäkijärvi(54)130Hewlett Packard HP1000+++Variable.81.79.44.95720NSNS
Malik(55)553ART 1200 EPX+++Any 2 parameters.58.72.09NS36050/553 (9)50/553 (9)
McClements(56)301Corozonix Predictor+++Any 1 parameter.64.80.11.9836713/301 (4)123/301 (4)
McGuire(36)50ART 101++dQRS or RMS40.80.47.27.901010/50 (20)29/50 (58)
Mercando(57)121ART 1200 EPX+++Any 2 parameters.52.68.32.83870±42048/121 (40)26/121 (21)
Pedretti(58)303Fidelity Medical LP 3000+++Any 2 parameters.79.75.17.98450±21019/303 (6)77/303 (25)
Reinhardt(59)769NS+dQRS.76.63.10.9818033/778 (4)266/778 (29)
Richards(60)225DEC 11/34+dQRS.55.82.17.97740 (median)34/225 (15)NS
Rodriguez(61)190NS++dQRS.39.91.48.8875033/190 (17)23/178 (12)
Steinberg(62)182Corozonix Predictor+++Any 1 parameter.69.64.15.95420±210 (30-960)38/182 (21)71/182 (39)
Turitto(27)90ART 101 PCD++dQRS or RMS40.75.78.14.980-51 (1)12/89 (13)
Verzoni(63)220ART 101+++Any 2 parameters.83.73.08.99360 (45-360)62/220 (28)46/192 (24)
Zimmerman(64)223Siemens Mingograph 82++LAS40 +dQRS.67.80.16.98450±13517/223 (8)45/223 (20)
a

Duration of the filtered QRS complex > 106 ms.

b

Root mean square voltage during the last 40 ms of the QRS complex <25 µV.

c

Duration of low-amplitude signals during the last 40 ms >38 ms.

d

SD, VT, or MI.

Abbreviations: ART = arrhythmia research technology; NS = not stated; +PV = positive predictive value; -PV = negative predictive value; Se = sensitivity; Sp = specificity; SD = sudden death; VT = ventricular tachycardia; MI = myocardial infarction.

From: Signal-Averaged Electrocardiography

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