From: Carrier Motility
Copyright © 2000-2013, Landes Bioscience.
- Adhesion Molecules
- Aging
- Angiogenesis
- Apoptosis
- Autophagy in Caenorhabditis elegans
- Apoptosis Dependent and Independent Functions of Caspases
- The Role of Caspases in Modulation of Cytokines and Other Molecules in Apoptosis and Inflammation
- Caspases, Bcl-2 Family Proteins and Other Components of the Death Machinery: Their Role in the Regulation of the Immune Response
- Learning from Deficiency: Gene Targeting of Caspases
- Caspase Activation in Cancer Therapy
- Caspase-Independent Cell Death Mechanisms
- Caspases as Targets for Drug Development
- In Situ Activation of Caspases Revealed by Affinity Labeling Their Enzymatic Sites
- Atherosclerosis
- Autoimmunity
- Targeting Antigen-Specific T Cells for Gene Therapy of Autoimmune Disease
- Cytokines in the Pathogenesis of Rheumatoid Arthritis and Collagen-Induced Arthritis
- Cytokines in the Treatment and Prevention of Autoimmune Responses
- Involvement of Cytokines in the Pathogenesis of Systemic Lupus Erythematosus
- Gene Therapy-Based Approach for Immune Tolerance Induction Using Recombinant Immunoglobulin Carriers
- Hematologic Diseases: Autoimmune Hemolytic Anemia and Immune Thrombocytopenic Purpura
- Gastroenterologic and Hepatic Diseases
- Inflammatory Myopathies: Dermatomyositis, Polymyositis and Inclusion Body Myositis
- Immunogene Therapy with Nonviral Vectors
- Cytokines and Chemokines in Autoimmune Disease: An Overview
- CTLA-4 in Type 1 Diabetes Mellitus
- 4-1BB as a Therapeutic Target for Human Disease
- NATURALLY OCCURRING ANTIBODIES AS THERAPEUTICS FOR NEUROLOGIC DISEASE: Can Human Monoclonal IgMs Replace the Limited Resource IVIg?
- Bioinformatics
- Biomaterials
- Biosurfactants
- Biotechnology
- Use of piggyBac and a Sindbis Virus for Foreign Gene Expression and RNAi in the Silkworm
- Molecular Properties of Voltage-Gated Calcium Channels
- Why Government Is the Problem (and What to Do about It)
- Transgenic Analysis of the Biological Functions of a Doublesex Homologue in Bombyx mori
- Carbon Nanostructures as a New High-Performance Platform for MR Molecular Imaging
- Foundations of E-Cell Simulation Environment Architecture
- Electrophysiological Simulation of Developmental Changes in Action Potentials of Cardiomyocytes
- Distributed Cell Biology Simulations with the E-Cell System
- Bacterial Vectors for RNAi Delivery
- HSV as a Vector in Vaccine Development and Gene Therapy
- Cancer Development
- Cancer Genetics
- Cancer Metastasis
- Integrins in Cancer Cell Invasion
- The Plasminogen Activation System in Cell Invasion
- Maspin: Functional Insights from a Structural Perspective
- Maspin and Pericellular Plasminogen Activation in Cell-Matrix Interaction
- Maspin Suppresses Breast Cancer Cell Invasiveness by Modulating Integrin Expression and Function
- The Role of Maspin in Tumor Progression and Normal Development
- The Role of Maspin in Human Placental Development
- Keratinocyte Interactions with Fibronectin during Wound Healing
- Sympathetic Nervous System Regulation of Metastasis
- Long Non-Coding RNA: Agent Provacateur in Breast Cancer Metastasis
- Investigating Metastasis Using In Vitro Platforms
- Modeling Metastasis In Vivo
- Cell Biology
- Intracellular Membrane Fusion
- The Golgi Apparatus
- Clathrin-Mediated Endocytosis
- Decoding the Signaling Mechanism of Toll-Like Receptor 4 Pathways in Wild Type and Knockouts
- Carrier Motility
- The Exocytic Pathway and Development
- Memory Th1/Th2 Cell Generation Controlled by Schnurri-2
- The “O” Class: Crafting Clinical Care with FoxO Transcription Factors
- FOXP Genes, Neural Development, Speech and Language Disorders
- Regulation and Coordination of Intracellular Trafficking: An Overview
- Overview of Intracellular Compartments and Trafficking Pathways
- Sumoylation as a Signal for Polyubiquitylation and Proteasomal Degradation
- Studies on the Very Large G Protein–Coupled Receptor From Initial Discovery to Determining Its Role in Sensorineural Deafness in Higher Animals
- Autosomal Lyonization of Replication Domains During Early Mammalian Development
- X Chromosome Inactivation and Embryonic Stem Cells
- NOTCH SIGNALING AND THE DEVELOPING HAIR FOLLICLE
- NOTCH SIGNALING AND THE GENERATION OF CELL DIVERSITY IN DROSOPHILA NEUROBLAST LINEAGES
- THE NEURAL BASIS OF SEMANTIC AND EPISODIC FORMS OF SELF-KNOWLEDGE: Insights from Functional Neuroimaging
- NOTCH SIGNALING AND THE DEVELOPING INNER EAR
- POLYALANINE TRACT DISORDERS AND NEUROCOGNITIVE PHENOTYPES
- NOTCH SIGNALING IN LUNG DEVELOPMENT AND DISEASE
- SELECTIVE NEURODEGENERATION, NEUROPATHOLOGY AND SYMPTOM PROFILES IN HUNTINGTON'S DISEASE
- Cell Cycle
- The Restriction Point of the Cell Cycle
- DNA Damage-Independent Checkpoints from Yeast to Man
- The Regulation of p53 Growth Suppression
- Functional Interactions Between BRCA1 and the Cell Cycle
- The Evolution of CDK-Activating Kinases
- CDK-Activating Kinases in Higher Plants
- Activating Phosphorylation of Cyclin-Dependent Kinases in Budding Yeast
- Cell Invasion
- Cell Metabolism
- Theory of Organelle Biogenesis: A Historical Perspective
- Microfibril-Associated Glycoprotein-1 (MAGP-1) and Other Non-fibrillin Macromolecules Which May Possess a Functional Association with the 10 nm Microfibrils
- Synaptic Endosomes
- Endocytosis of Receptor Tyrosine Kinases: Implications for Signal Transduction by Growth Factors
- Macroautophagy in Mammalian Cells
- Plant Lipocalins
- The Plasma Lipocalins α1-Acid Glycoprotein, Apolipoprotein D, Apolipoprotein M and Complement Protein C8γ
- Molecular Biology of the OXPHOS System
- Bacterial Lipocalins: Origin, Structure, and Function
- Chaperone-Mediated Autophagy
- Regulation of Paracellular Transport across Tight Junctions by the Actin Cytoskeleton
- Entry into the Endoplasmic Reticulum: Protein Translocation, Folding and Quality Control
- Tight Junction Proteins and Cancer
- Membrane Resealing Mediated by Lysosomal Exocytosis
- Transcriptional Regulation of Keratin Gene Expression
- Lysosomal Proteases: Revival of the Sleeping Beauty
- Preprotein Translocation through the Sec Translocon in Bacteria
- Molecular Basis of Oncogenesis by NF-κB: From a Bird's Eye View to a RELevant Role in Cancer
- Nuclear Import of Agrobacterium T-DNA
- Keratins As Targets in and Modulators of Liver Diseases
- Retinol Binding Protein and Its Interaction with Transthyretin
- Keratin Intermediate Filaments and Diseases of the Skin
- Important Mammalian Respiratory Allergens Are Lipocalins
- Lipocalin Receptors: Into the Spotlight
- α1-Microglobulin
- Lipocalins in Clinical Medicine
- Lysosomal Storage Disorders
- Lipocalins in Arthropoda: Diversification and Functional Explorations
- Lipocalin-Type Prostaglandin D Synthase as an Enzymic Lipocalin
- Glycodelin: A Lipocalin with Diverse Glycoform-Dependent Actions
- Nonsecretory, Regulated Exocytosis: A Multifarious Mechanism Employed by Cells to Carry Out a Variety of Functions
- Protein Misassembly: Macromolecular Crowding and Molecular Chaperones
- Molecular Interaction Network of the Hsp90 Chaperone System
- The Synapsins and the Control of Neuroexocytosis
- Hsp90 and Developmental Networks
- A Common Binding Site for Actin-Binding Proteins on the Actin Surface
- The Role of Synaptotagmin and Synaptotagmin-Like Protein (Slp) in Regulated Exocytosis
- Cell-Free Synthesis of Defined Protein Conjugates by Site-directed Cotranslational Labeling
- Reverse Engineering Models of Cell Cycle Regulation
- Nuclear Import of Plant Proteins
- Dynamic Connections of Nuclear Envelope Proteins to Chromatin and the Nuclear Matrix
- Nuclear Envelope Dynamics in Drosophila Pronuclear Formation and in Embryos
- Nuclear Envelope Breakdown and Reassembly in C. elegans: Evolutionary Aspects of Lamina Structure and Function
- Laminopathies: One Gene, Two Proteins, Five Diseases..
- Dynamics of Nuclear Envelope Proteins During the Cell Cycle in Mammalian Cells
- Calnexin and Calreticulin, Molecular Chaperones of the Endoplasmic Reticulum
- Calreticulin-Mediated Nuclear Protein Export
- Calreticulin and the Endoplasmic Reticulum in Plant Cell Biology
- Calnexin and Calreticulin, ER Associated Modulators of Calcium Transport in the ER
- ER Calcium and ER Chaperones: New Players in Apoptosis?
- Calreticulin in Cytotoxic Lymphocyte-Mediated Cytotoxicity
- A Role for Calreticulin in the Clearance of Apoptotic Cells and in the Innate Immune System
- Calreticulin and Tumor Suppression
- Cell Surface Calreticulin: Role in Signaling Thrombospondin Anti-Adhesive Activity
- Calreticulin Regulation of Lung Endothelial NOS Activity
- Channels and Transporters
- Cell-Cell Fusion: Transient Channels Leading to Plasma Membrane Merger
- Anion Conduction by CFTR: Mechanisms and Models
- Voltage-Dependent Inactivation of Voltage Gated Calcium Channels
- A Brief History of Calcium Channel Discovery
- Biochemical Studies of Voltage-Gated Ca2+ Channels
- Block of Voltage-Gated Calcium Channels by Peptide Toxins
- Calcium Channel Block and Inactivation: Insights from Structure-Activity Studies
- Ca2+ Chemistry, Storage and Transport in Biologic Systems: An Overview
- Hepatic Copper Transport
- Drug-Induced Cholestatic Liver Disease
- Cell-Cell Channels and Their Implications for Cell Theory
- Cytoplasmic Bridges in Volvox and Its Relatives
- Gap Junctions: Cell-Cell Channels in Animals
- The Tetrahymena Conjugation Junction
- Mating Cell-Cell Channels in Conjugating Bacteria
- Fusome as a Cell-Cell Communication Channel of Drosophila Ovarian Cyst
- Channels across Endothelial Cells
- Cytonemes as Cell-Cell Channels in Human Blood Cells
- Vegetative Hyphal Fusion in Filamentous Fungi
- Fat Absorption and Lipid Metabolism in Cholestasis
- Genetics, Mutations, and Polymorphisms
- Hepatocyte Transplantation and Liver-Directed Gene Therapy
- Phylogeny of Major Intrinsic Proteins
- Chaperones
- Circadian Rhythms
- Coagulation
- Regulation of Tissue Factor Expression
- Factor XI, TAFI and DIC
- Cytokines as Regulators of Coagulation
- DIC at the Intersection of the Thrombotic, Fibrinolytic and Inflammatory Axes
- Genetic Risk Factors for Disseminated Intravascular Coagulation
- Endothelial Cell Perturbation and Disseminated Intravascular Coagulation
- Blood-Borne Tissue Factor (Including Microparticles)
- Cytokines/Growth Factors
- Development
- Embryonic Salivary Gland Branching Morphogenesis
- Integrins and Development: Integrins in Skeletal Cell Function and Development
- Membrane Lipid Rafts and Their Role in Axon Guidance
- Epithelial-Mesenchymal Transformation in the Embryonic Heart
- GSK3-Signal Regulation of Pattern Formation in Dictyostelium: Wnt-Like Pathways During Non-Canonical Multicellular Development
- Functional and Ecological Effects of Isoform Variation in Insect Flight Muscle
- Change of Epithelial Fate: Lessons from Gastrulation in Drosophila
- Cadherin-Mediated Cell-Cell Adhesion and the Microtubule Network
- TGFβ-dependent Epithelial-Mesenchymal Transition
- Branching Morphogenesis of the Prostate
- Expression and Function of Pitx2 in Chick Heart Looping
- Neural Crest and the Development of the Enteric Nervous System
- Matrix Metalloproteases and Epithelial-to-Mesenchymal Transition: Implications for Carcinoma Metastasis
- Whole Genome Approaches to Studying Drosophila Muscle Development
- Muscle Morphogenesis: The Process of Embryonic Myoblast Fusion
- Development of the Larval Somatic Musculature
- The Pathophysiological Role of Impaired Calcium Handling in Muscular Dystrophy
- X-Ray Diffraction of Indirect Flight Muscle from Drosophila in Vivo
- The Sarcoglycans
- The Role of Insulin-like Growth Factors in the Epithelial to Mesenchymal Transition
- Epithelium–Mesenchyme Transitions Are Crucial Morphogenetic Events Occurring During Early Development
- How Is the Branching of Animal Blood Vessels Implemented?
- Integrins and Associated Proteins in Drosophila Development
- Roles for Integrins and Associated Proteins in the Haematopoietic System
- Development of the Cardiac Musculature
- Shh/Gli Signaling During Murine Lung Development
- New Perspectives in Shh Signalling?
- Role of shh and Gli Signalling in Oligodendroglial Development
- Branching Morphogenesis in Vertebrate Neurons
- Sonic Hedgehog Signaling in the Developing and Regenerating Fins of Zebrafish
- Role of Hedgehog and Gli Signalling in Telencephalic Development
- Structure and Function of the Dystrophin-Glycoprotein Complex
- Caveolin-3 and Limb-Girdle Muscular Dystrophy
- Lamins and Emerin in Muscular Dystrophy: The Nuclear Envelope Connection
- Cranial Neural Crest and Development of the Head Skeleton
- Mesoderm Formation in the Drosophila Embryo
- Neural Crest Delamination and Migration: Integrating Regulations of Cell Interactions, Locomotion, Survival and Fate
- Insect Flight Muscle Chemomechanics
- The Role of Integrins in Cell Migration
- Neural Crest Cell Plasticity: Size Matters
- Neural Crest Stem Cells
- Integrins: An Overview of Structural and Functional Aspects
- An Evolutionary Perspective on Eukaryotic Membrane Trafficking
- Slits and Their Receptors
- Origins and Evolution of Cotranslational Transport to the ER
- Origins and Evolution of the Actin Cytoskeleton
- Comparison of Muscle Development in Drosophila and Vertebrates
- Neural Crest Cells and the Community of Plan for Craniofacial Development: Historical Debates and Current Perspectives
- The Genetic Regulation of Pigment Cell Development
- Origin and Evolution of Self-Consumption: Autophagy
- The Contribution of the Neural Crest to the Vertebrate Body
- Dorsoventral Patterning of the Brain: A Comparative Approach
- VEGF and Endothelial Guidance in Angiogenic Sprouting
- CtBP and Hematopoietic Transcriptional Regulators
- A New Member of the CtBP/BARS Family from Plants: Angustifolia
- Simulation of Human Erythrocyte Metabolism
- A Model Library of Bacterial Chemotaxis on E-Cell System
- CtBP3/BARS and Membrane Fission
- Hsp70-Mediated Protein Refolding in E-Cell
- VEGF Receptor Signalling in Vertebrate Development
- Vascular and Nonvascular Roles of VEGF in Bone Development
- Morphogenesis of Epithelial Appendages: Variations on Top of a Common Theme and Implications in Regeneration
- Wnt/Wingless Signaling in Drosophila
- The Role of Wnt Signaling in Vertebrate Head Induction and the Organizer-Gradient Model Dualism
- The Wnt Gene Family and the Evolutionary Conservation of Wnt Expression
- Secreted Antagonists/Modulators of Wnt Signaling
- Patterning the Vertebrate Neural Plate by Wnt Signaling
- Wnt/Wg and Heart Development
- Wnt Signaling and Cell Migration
- DNA Surveillance and Repair
- Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity
- PARP and the Release of Apoptosis-Inducing Factor from Mitochondria
- DNA Damage Signaling through Poly(ADP-Ribose)
- Dynamic Interaction between PARP-1, PCNA and p21waf1/cip1
- Parp and Epigenetic Regulation
- Genome Degradation by DNAS1L3 Endonuclease: A Key PARP-1-Regulated Event in Apoptosis
- Role of Poly-ADP-Ribosylation in Cancer Development
- The Fanconi Anemia/BRCA Pathway: FANCD2 at the Crossroad between Repair and Checkpoint Responses to DNA Damage
- Fluorescence-Signaling Nucleic Acid-Based Sensors
- Trichothiodystrophy: A Disorder Highlighting the Crosstalk between DNA Repair and Transcription
- Mobile Genetic Elements of Malaria Vectors and Other Mosquitoes
- Orchestration of Telomeres and DNA Repair Factors in Mammalian Cells: Implications for Cancer and Ageing
- Mechanisms of DNA Damage and Repair in Alzheimer Disease
- Origin, Recognition, Signaling and Repair of DNA Double-Strand Breaks in Mammalian Cells
- The Tn4371 ICE Family of Bacterial Mobile Genetic Elements
- The Tn916/Tn1545 Family of Conjugative Transposons
- Restriction-Modification Systems as Mobile Epigenetic Elements
- DNA Vaccines
- Drug Design
- Endocrinology
- Regulation of Insulin Action and Insulin Secretion by SNARE-Mediated Vesicle Exocytosis
- Subcellular Compartmentalization of Insulin Signaling Processes and GLUT4 Trafficking Events
- Insulin Action in the Islet β-Cell
- What Is Osteoporosis?
- Insulin and IGF-I Receptor Structure and Binding Mechanism
- Insulin Resistance
- Insulin Action Gene Regulation
- Evolution
- Ribozyme-Catalyzed Genetics
- Origin and Evolution of DNA and DNA Replication Machineries
- Life in a Tenuous Universe
- The Frame for New Hypotheses of Evolution
- Genomism and the Nature Trail
- The Origin of Complexity
- Our Young Planet: One Is Not a Choice
- The Condensation of Life
- The Origins of Species
- Development of Biological Potential
- Thoughts on Multi-Cellularity: How Nature Got Around Darwin
- Natura non facit saltum (Nature does nothing in jumps)
- The Invariance Concept
- On the Evolution of Humans
- Molecular Geneology
- Experiments in Evolution
- Quintessence
- The Scope of Selection
- Extracellular Matrix
- Gastroenterology
- Functional Heterogeneity of the Intrahepatic Biliary Epithelium
- Bile Acid Interactions with Cholangiocytes
- Estrogen Regulation of Cholangiocyte Proliferation
- Nerve Regulation of Cholangiocyte Functions
- Vascularization of the Intrahepatic Biliary Tree and Its Role in the Regulation of Cholangiocyte Growth
- Cytokine Regulation of Cholangiocyte Growth
- Hyperemesis Gravidarum and Maternal Liver Disease
- The Liver in Normal Pregnancy
- Spectrum of Maternal Liver Disease
- Gene Expression
- Stochastic Gene Expression: Dominance, Thresholds and Boundaries
- Biological Consequences of Dosage Dependent Gene Regulation in Multicellular Eukaryotes
- GAGA: Structural Basis for Single Cys2His2 Zinc Finger-DNA Interaction
- Identification of Mammalian E2F Regulatory Networks Using DNA Microarray Hybridization Analyses
- Homing Endonuclease I-TevI: An Atypical Zinc Finger with a Novel Function
- A Novel Test Statistic for the Identification of Local Selective Sweeps Based on Microsatellite Gene Diversity
- Periodic Selection and Ecological Diversity in Bacteria
- LIM Domain and Its Binding to Target Proteins
- Inferring Evolutionary History through Inter- and Intraspecific DNA Sequence Comparison: The Drosophila janus and ocnus Genes
- Selective Sweep in the Evolution of a New Sperm-Specific Gene in Drosophila
- The Superfamily of SCAN Domain Containing Zinc Finger Transcription Factors
- Putative Roles of kin17, a Mammalian Protein Binding Curved DNA, in Transcription
- CtBP Family Proteins: Unique Transcriptional Regulators in the Nucleus with Diverse Cytosolic Functions
- A Zinc Ribbon Motif Is Essential for the Formation of Functional Tetrameric Protein Kinase CK2
- Rapid Evolution of Sex-related Genes: Sexual Conflict or Sex-specific Adaptations?
- Repression of Transcription by Curved DNA and Nucleoid Protein H-NS: A Mode of Bacterial Gene Regulation
- Curved DNA and Transcription in Eukaryotes
- PNA and Oligonucleotide Inhibitors of Human Telomerase
- Possible Roles of DNA Supercoiling in Transcription
- MDM2: RING Finger Protein and Regulator of p53
- Gene Regulatory Networks
- Do DNA Triple Helices or Quadruplexes Have a Role in Transcription?
- The Biology of Telomeres in Hypotrichous Ciliates
- Scaling Laws in the Functional Content of Genomes: Fundamental Constants of Evolution?
- Regulation of Cardiomyocyte Proliferation and Apoptosis
- Cell Cycle Reactivation in Skeletal Muscle and Other Terminally Differentiated Cells
- The Role of Unusual DNA Structures in Chromatin Organization for Transcription
- Molecular Mechanisms of Male Sex Determination: The Enigma of SRY
- DNA: Alternative Conformations and Biology
- Curved DNA and Prokaryotic Promoters: A Mechanism for Activation of Transcription
- Scale-Free Evolution: From Proteins to Organisms
- Bioinformatics: Mystery, Astrology or Service Technology?
- Extracting Information for Meaningful Function Inference Through Text-Mining
- Microarrays and Gene Regulation Networks in Yeast
- Transcriptional Repression by the CtBP Corepressor in Drosophila
- Structural Determinants of CtBP Function
- Analytical Evolutionary Model for Protein Fold Occurrence in Genomes, Accounting for the Effects of Gene Duplication, Deletion, Acquisition and Selective Pressure
- Power Law Correlations in DNA Sequences
- Transcriptional Networks in Mammalian Gene Regulation
- DNA Primer Extension by Telomerase
- Transcriptional Profiling of the Hepatic Growth Response
- Expression of Hox Genes in the Nervous System of Vertebrates
- Telomeres: Guardians of Genomic Integrity or Double Agents of Evolution?
- Alternative Lengthening of Telomeres in Mammalian Cells
- Evolution of Telomere Binding Proteins
- Drosophila Telomeres: A Variation on the Telomerase Theme
- Telomerase Activity as a Marker of Tumor Cell Survival to Evaluate Sensitivity of Neoplastic Cells to Cancer Treatment
- Myotonic Dystrophy: Discussion of Molecular Basis
- Roles for TERT and Telomerase in Cell Differentiation and Apoptosis
- Molecular Mechanisms of TRS Instability
- Yeast Telomerases: Structure, Mechanisms and Regulation
- The Significance of Quantitative Evaluation of Telomerase Activity and hTERT mRNA Expression in Colorectal Cancers
- Human, Mouse and Yeast Telomerase
- Telomerase in Mesothelioma: Diagnostic and Therapeutic Applications
- Telomerase Activity in Neuroblastomas: A New Molecular Marker for Treatment Stratification and Prognostic Grouping
- Telomerase and Radiosensitivity of Human Tumors
- Heart
- Heat Shock Proteins
- Hematology
- Immunology
- Animal Models of OXPHOS Disorders
- Molecular Recognition of Haptens by T Cells: More Than One Way to Tickle the Receptor
- Phospholipases and Phagocytosis
- IgA and Mucosal Homeostasis
- Carbohydrate-Based Targets and Vehicles for Cancer and Infectious Diseases Vaccines
- Small GTP Binding Proteins and the Control of Phagocytic Uptake
- Calcium Signaling During Phagocytosis
- Regulation of Phagocytosis by FcγRIIb and Phosphatases
- Adding Complexity to Phagocytic Signaling: Phagocytosis-Associated Cell Responses and Phagocytic Efficiency
- V(D)J Recombination: Of Mice and Sharks
- Opioid Receptors on Peripheral Sensory Neurons
- Morphological Correlates of Immune-Mediated Peripheral Opioid Analgesia
- Functional Evidence of Pain Control by the Immune System
- Opioid Receptor Expression and Intracellular Signaling by Cells Involved in Host Defense and Immunity
- Experimental Evidence for Immunomodulatory Effects of Opioids
- The Immune-Suppressive Effects of Pain
- Lipoxins as an Immune-Escape Mechanism
- Dynamic Aspects of TCRα Gene Recombination: Qualitative and Quantitative Assessments of the TCRα Chain Repertoire in Man and Mouse
- Viral TNF Inhibitors as Potential Therapeutics
- CD8 T-Cell Memory Differentiation during Acute and Chronic Viral Infections
- Chromatin Mechanisms Regulating Gene Expression In Health And Disease
- Earthworm Immunity
- TRIM PROTEINS AS RING FINGER E3 UBIQUITIN LIGASES
- REGULATORS OF CA2+ SIGNALING IN MAST CELLS Potential Targets for Treatment of Mast-Cell Related Diseases?
- GASTROPOD IMMUNOBIOLOGY
- MAST CELLS AND IMMUNOREGULATION/IMMUNOMODULATION
- MAST CELL PROTEASES AS PROTECTIVE AND INFLAMMATORY MEDIATORS
- Innate Immune Evasion Strategies of HCV and HIV: Common Themes for Chronic Viral Infection
- Infectious Disease
- Everything (or Almost Everything) You Want to Know about Genetically Modified Mosquitoes for Malaria Control but Are (Maybe) Afraid to Ask
- Predicting the Spread of a Transgene in African Malaria Vector Populations: Current Knowledge and Limitations
- Invasion and Intracellular Survival by Toxoplasma
- Negative Signaling and Modulation of Macrophage Function in Trypanosoma cruzi Infection
- Pro-Inflammatory Responses in Macrophages during Toxoplasma gondii Infection
- Avoidance of Innate Immune Mechanisms by the Protozoan Parasite, Leishmania spp
- Insect Population Suppression Using Engineered Insects
- Current and Emerging Approaches to Studying Invasion in Apicomplexan Parasites
- CATHEPSIN PROTEASES IN TOXOPLASMA GONDII
- Ischemia-Reperfusion
- Medical
- Mitochondria
- Molecular Biology
- Gas7
- RNA Modification Subsystems in the SEED Database
- KIR Genes and Their Role in Spondyloarthropathies
- Antibiotic Resistance in Bacteria Caused by Modified Nucleosides in 23S Ribosomal RNA
- The “PACE” Concept Pointed at New Key Proteins Involved in RNA Metabolism
- DNA Demethylation
- Adhesion-Dependent Modulation of Macrophage K+ Channels
- Pseudouridine Formation, the Most Common Transglycosylation in RNA
- Folate-Dependent Thymidylate-Forming Enzymes: Parallels between DNA and RNA Metabolic Enzymes and Evolutionary Implications
- The Interplay between RNA and DNA Modifications: Back to the RNA World
- Deciphering the Complex Enzymatic Pathway for Biosynthesis of Wyosine Derivatives in Anticodon of tRNAPhe
- Nucleic Acids Are Not Boring Long Polymers of Only Four Types of Nucleotides: A Guided Tour
- Chemokine Binding Proteins Encoded by Pathogens
- Boomerangs, Bananas and Blimps: Structure and Function of F-BAR Domains in the Context of the BAR Domain Superfamily
- Enzyme-RNA Substrate Recognition in RNA-Modifying Enzymes
- Nanomedicine
- Neurodegenerative Disease
- DSD-1-Proteoglycan/Phosphacan and Receptor Protein Tyrosine Phosphatase-Beta Isoforms During Development and Regeneration of Neural Tissues
- Interleukin-10 and Psoriasis
- Idiopathic Parkinson's Disease: Staging an α-Synucleinopathy with a Predictable Pathoanatomy
- Chromosome 1 and Other Hotspots for Parkinson's Disease Genes
- Fibroblast Growth Factors
- Neuronal Survival and Cell Death Signaling Pathways
- Paved with Good Intentions: The Link between Cell Cycle and Cell Death in the Mammalian Central Nervous System
- α-Synuclein Physiology and Membrane Binding
- Na Channels and Ca2+ Channels of the Cell Membrane as Targets of Neuroprotective Substances
- Heat Shock Proteins and Neuroprotection
- Blood-Brain Barrier Drug Targeting Enables Neuroprotection in Brain Ischemia Following Delayed Intravenous Administration of Neurotrophins
- Neuroprotective Strategies in Animal and in Vitro Models of Neuronal Damage: Ischemia and Stroke
- Vascular Endothelial Growth Factor
- Cell Cycle and Chromosome Segregation Defects in Alzheimer's Disease
- Neuroprotective Activity of Metabotropic Glutamate Receptor Ligands
- Excitatory Amino Acid Neurotoxicity
- Dopamine and Parkinson's Disease
- Neurotrophins
- Overview Αβ Metabolism: From Alzheimer Research to Brain Aging Control
- β-Secretase: Progress and Open Questions
- APP α-Secretase, a Novel Target for Alzheimer Drug Therapy
- γ-Secretase and Presenilin
- Functional Roles of APP Secretases
- Proteolytic Degradation of Αβ by Neprilysin and Other Peptidases
- Αβ Degradation by Endothelin-Converting Enzymes
- Ab Metabolism in Cholesterol-Enriched Membrane Microdomains
- Amyloid β-Protein in Low-Density Membrane Domains
- Transport-Clearance Hypothesis for Alzheimer's Disease and Potential Therapeutic Implications
- Potential Role of Endogenous and Exogenous Ab Binding Molecules in Ab Clearance and Metabolism
- Modulating Amyloid β Levels by Immunotherapy: A Potential Therapeutic Strategy for the Prevention and Treatment of Alzheimer's Disease
- Neuropharmacology
- Diurnal 5-HT Production and Melatonin Formation
- Pineal Gland and Cancer—An Epigenetic Approach to the Control of Malignancy: Evaluation of the Role of Melatonin
- Cell Adhesion Molecules
- Risks of Chronic Hypnotic Use
- Sleep Hippocampal Theta Rhythm and Sensory Processing
- Cannabinoid Receptors and Signal Transduction
- Protein Kinase A
- A Comparison of Visual Analog Scale and Categorical Ratings in Assessing the Patient's Estimate of Sleep Quality
- Neuroscience
- Nucleus
- Oncogenes
- Oncology
- Fever, Pyrogens and Cancer
- Gene Expression Profiling in Malignant Lymphomas
- Cytoreduction, Peritonectomy and Hyperthermic Antiblastic Peritoneal Perfusion for the Treatment of Peritoneal Carcinomatosis
- Hyperthermic Isolated Limb Perfusion
- Intracavitary Hyperthermic Perfusion
- Locoregional Hyperthermia
- Transcription of rDNA in the Yeast Saccharomyces cerevisiae
- Pre-Ribosomal RNA Processing in Multicellular Organisms
- PDGF Pathways and Growth of Basal Cell and Squamous Cell Carcinomas
- Extreme Whole-Body Hyperthermia with Water-Filtered Infrared-A Radiation
- Influence of Tumor Microenvironment on Thermoresponse: Biologic and Clinical Implications
- Physical Background and Technical Realizations of Hyperthermia
- Effects of Local and Whole Body Hyperthermia on Immunity
- Thermo-Chemo-Radiotherapy Association: Biological Rationale, Preliminary Observations on Its Use on Malignant Brain Tumors
- Molecular Mechanisms of ErbB2-Mediated Breast Cancer Chemoresistance
- Future Perspectives of Interstitial and Perfusional Hyperthermia
- Roles of Multidrug Resistance Genes in Breast Cancer Chemoresistance
- Insulin-Like Growth Factors and Breast Cancer Therapy
- Novel Approaches for Chemosensitization of Breast Cancer Cells: The E1A Story
- Whole Body Hyperthermia at 43.5-44°C: Dreams or Reality?
- Overview of Resistance to Systemic Therapy in Patients with Breast Cancer
- Microarrays for Cancer Diagnosis and Classification
- Monophosphoryl Lipid A (MPL) as an Adjuvant for Anti-Cancer Vaccines: Clinical Results
- Cellular Interactions in Nasopharyngeal Carcinomas
- Protein
- Structure, Function and Assembly of Flagellar Axial Proteins
- Implications of 3D Domain Swapping for Protein Folding, Misfolding and Function
- From Artificial Antibodies to Nanosprings:The Biophysical Properties of Repeat Proteins
- The Budding Yeast PCH/F-BAR Proteins
- The Coronin Family of Proteins
- Diversity of WD-repeat Proteins
- A Brief History of the Coronin Family
- Phylogenetic, Structural and Functional Relationships between WD-and Kelch-Repeat Proteins
- The Role of Mammalian Coronins in Development and Disease
- Invertebrate Coronins
- Evolutionary and Functional Diversity of Coronin Proteins
- Coronin: The Double-Edged Sword of Actin Dynamics
- Coronin 1 in Innate Immunity
- Molecular Phylogeny and Evolution of the Coronin Gene Family
- Coronin Structure and Implications
- Nuclear APC
- Role of Mammalian Coronin 7 in the Biosynthetic Pathway
- Post-Targeting Functions of Signal Peptides
- STRUCTURAL DISORDER AND PROTEIN ELASTICITY
- Reproductive Biology
- Splitting Hairs: Dissecting the Roles of Gli Activator and Repressor Functions during Epidermal Development and Disease
- Bi-Directional Cell Trafficking During Pregnancy: Long-term Consequences for Human Health
- Immunology and Pregnancy Losses: HLA, Autoantibodies and Cellular Immunity
- The Role of Corticotropin-Releasing Hormone (CRH) on Implantation and Immunotolerance of the Fetus
- Characterization of Human Dendritic Cells at the Maternal-Fetal Interphase
- Important Role of Shh Controlling Gli3 Functions During the Dorsal-Ventral Patterning of the Telencephalon
- Spatial and Temporal Regulation of Hair Follicle Progenitors by Hedgehog Signalling
- MHC Molecules of the Preimplantation Embryo and Trophoblast
- The Role of Regulatory T Cells in Materno-Fetal Tolerance
- Cytogenetics of Human Sperm
- Preimplantation Genetic Diagnosis (PGD): Screening for Aneuploidy in Human Oocytes and Polar Bodies
- Proteases and Their Cognate Inhibitors of the Serine and Metalloprotease Subclasses, in Testicular Physiology
- Antioxidant Systems and Oxidative Stress in the Testes
- RNA
- Protein-Switched Ribozymes
- Proteins Carrying One or More Unnatural Amino Acids
- Therapies of Nonsense-Associated Diseases
- All Termination Events Are Not Equal: Premature Termination in Yeast Is Aberrant and Triggers NMD
- Role of SMG-1-mediated Phosphorylation of Upf1 in NMD
- NMD in Drosophila: A Snapshot into the Evolution of a Conserved mRNA Surveillance Pathway
- The snoRNPs and Related Machines: Ancient Devices That Mediate Maturation of rRNA and Other RNAs
- Trytophanyl-tRNA Synthetases
- Tyrosyl-tRNA Synthetases
- Cytokines, Chemokines and Their Receptors
- Valyl-tRNA Synthetases
- Protein-Induced RNA Switches in Nature
- Class I Lysyl-tRNA Synthetases
- Glutaminyl-tRNA Synthetases
- Asparaginyl-tRNA Synthetases
- Protein Tagging and Ribosome Rescue in Bacteria Requires the Recognition of Transfer-Messenger RNA by an Aminoacyl-tRNA Synthetase
- Aminoacyl-tRNA Synthetases and Disease
- Human Upf Proteins in NMD
- Phenylalanyl-tRNA Synthetases
- Regulation of Gene Expression by Coupling of Alternative Splicing and NMD
- NMD and Human Disease
- Polyadenylation and Degradation of RNA in Prokaryotes
- Regulation of the Expression of Aminoacyl-tRNA Synthetases and Translation Factors
- Conformational Dynamics within the Ribosome
- Tests of a Stereochemical Genetic Code
- Evasion of Phagosome Lysosome Fusion and Establishment of a Replicative Organelle by the Intracellular Pathogen Legionella pneumophila
- The End in Sight: Poly(A), Translation and mRNA Stability in Eukaryotes
- Recoding: Site- or mRNA-Specific Alteration of Genetic Readout Utilized for Gene Expression
- Mechanism of Translation Initiation in Eukaryotes
- A Prelude to Translational (Re)Initiation
- Mitochondrial Aminoacyl-tRNA Synthetases
- Transfer RNA Structure and Identity
- Post-Transcriptional Gene Silencing in Plants
- Turnover of Mature miRNAs and siRNAs in Plants and Algae
- miRNAs need a Trim Regulation of miRNA Activity by Trim-NHL Proteins
- Structural Components and Architectures of RNA Exosomes
- C. ELEGANS STAR PROTEINS, GLD-1 AND ASD-2, REGULATE SPECIFIC RNA TARGETS TO CONTROL DEVELOPMENT
- SPLICEOSOMAL RNA INFRASTRUCTURE: The Network of Splicing Components and their Regulation by miRNAs
- HOW OLD ARE RNA NETWORKS?
- THE RNA INFRASTRUCTURE: An Introduction to ncRNA Networks
- RNA NETWORKS IN PROKARYOTES I: CRISPRs and Riboswitches
- RNA NETWORKS IN PROKARYOTES II: tRNA Processing and Small RNAs
- PROMOTER-ASSOCIATED LONG NONCODING RNAs REPRESS TRANSCRIPTION THROUGH AN RNA BINDING PROTEIN TLS
- RNA BINDING DOMAINS AND RNA RECOGNITION BY RNA-EDITING MACHINERIES
- RNA-BINDING PROTEINS IN FUNGI AND THEIR ROLE IN mRNA LOCALIZATION
- FROM STRUCTURE TO FUNCTION OF RNA BINDING DOMAINS
- Signal Transduction
- Genetic Susceptibility to Infectious Diseases Linked to NRAMP1 Gene in Farm Animals
- FasL-Independent Activation of Fas
- Plant Metal Transporters with Homology to Proteins of the NRAMP Family
- Regulation of Bacterial MntH Genes
- Physiological Roles and Mechanisms of Signaling by TRAF2 and TRAF5
- Metal-ion Transporters— From Yeast to Human Diseases
- The Function of Toll-Like Receptors
- Regulation of the RhoGTPases by RhoGDI
- How the Hedgehog Outfoxed the Crab: Interference with HEDGEHOG-GLI Signaling as Anti-Cancer Therapy?
- Rho Family GTPases and Cellular Transformation
- GLI Genes and Their Targets in Epidermal Development and Disease
- Regulation of Cell Motility by Abl Family Kinases
- The Patched Receptor: Switching On/Off the Hedgehog Signaling Pathway
- Shh Expression in Pulmonary Injury and Disease
- Regulation of Cell Adhesion Responses by Abl Family Kinases
- Abl Family Kinases in Mammalian Development
- Abl and Cell Death
- Mechanisms of Activation of Abl Family Kinases
- Regulation of Cytoskeletal Dynamics and Cell Morphogenesis by Abl Family Kinases
- TRAFs in RANK Signaling
- Abelson Family Protein Tyrosine Kinases and the Formation of Neuronal Connectivity
- The LTβR Signaling Pathway
- Neurons, Neurotrophins and Ceramide Signaling: Do Domains and Pores Contribute to the Dichotomy?
- The Role of Serine/Threonine Protein Phosphatases in Ceramide Signaling
- Chaperone Effects on Prion and Nonprion Aggregates
- Insights into the Modulation of Ceramide Metabolism by Naturally Occurring and Synthetic Sphingolipid Analogs as Monitored by Electrospray Tandem Mass Spectrometry
- Ceramide Glycosylation and Chemotherapy Resistance
- S-Modulin
- Regulation of Voltage-Sensitive Ca2+ Channels in Bipolar Cells by Divalent Cations and Polyamines
- Target Recognition of Guanylate Cyclase by Guanylate Cyclase-Activating Proteins
- Centrins, a Novel Group of Ca2+-Binding Proteins in Vertebrate Photoreceptor Cells
- The TRP Calcium Channel and Retinal Degeneration
- Ca2+-dependent Control of Rhodopsin Phosphorylation: Recoverin and Rhodopsin Kinase
- The Complex of cGMP-gated Channel and Na/Ca2+, K Exchanger in Rod Photoreceptors
- RGS9-1 Phosphorylation and Ca2+
- Ceramide in the Regulation of Neuronal Development: Two Faces of a Lipid
- Therapeutic Implications of Ceramide-Regulated Signaling Cascades
- Photoreceptor Degeneration and Ca2+ Influx through Light-Activated Channels of Drosophila
- Regulation of the Rod Photoreceptor Cyclic Nucleotide-Gated Channel
- Mouse Models to Study GCAP Functions in Intact Photoreceptors
- Using Mutant Mice to Study the Role of Voltage-Gated Calcium Channels in the Retina
- Calcium Channels at the Photoreceptor Synapse
- Biosynthesis of Sphingolipids in Plants (and Some of Their Functions)
- Ceramide 1-Phosphate in Cell Survival and Inflammatory Signaling
- MSK1 and Nuclear Receptors Signaling
- Stimuli That Activate MSK in Cells and the Molecular Mechanism of Activation
- Stem Cells
- Tissue Engineering
- Scleroderma Lung Fibroblasts: Contractility and Connective Tissue Growth Factor
- Repair of Osteochondral Lesions
- Regulatory Issues: Down to the Bare Bones
- Anatomy and Physiology of the Spinal Cord
- Encouraging Regeneration of Host Neurones: The Use of Peripheral Nerve Bridges, Glial Cells or Biomaterials
- Replacement of Specific Neuronal Populations in the Spinal Cord
- Replacement of Specific Populations of Cells: Glial Cell Transplantation into the Spinal Cord
- In Vitro Endothelialization: Its Contribution Towards an Ideal Vascular Replacement
- Biocompatibility of Polyurethanes
- Tissue Repair in Asthma: The Origin of Airway Subepithelial Fibroblasts and Myofibroblasts
- Functional Assessment of Fibroblast Heterogeneity by the Cell-Surface Glycoprotein Thy-1
- Pro-Invasive Molecular Cross-Signaling between Cancer Cells and Myofibroblasts
- Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinase and Matrix Turnover and the Fate of Hepatic Stellate Cells
- Transplant
- Vaccines
- Viruses
- A Role for Chemokine Activity in Alphavirus Pathogenesis: Evidence from the Analysis of Polyarthritis and Myalgia Post-Ross River Virus Infection
- Evolutionary Aspects of Human Endogenous Retroviral Sequences (HERVs) and Disease
- Structure and Replication of Hepatitis Delta Virus RNA
- Hepatitis Delta Virus RNA Editing
- Hepatitis Delta Antigen and RNA Polymerase II
- Transforming Activities of JC Virus Early Proteins
- DNA Packaging by Bacteriophage P22
- Regulation of T Cell Immunity by OX40 and OX40L
- BK Virus, JC Virus and Simian Virus 40 Infection in Humans, and Association with Human Tumors
- The ø29 DNA Packaging Motor: Seeking the Mechanism
- Phylogenomics and Molecular Evolution of Polyomaviruses
- Urine Cytology Findings of Polyomavirus Infections
- Immunity and Autoimmunity Induced by Polyomaviruses: Clinical, Experimental and Theoretical Aspects
- Soluble Chemokine Binding Proteins Encoded by Viruses
- Bacteriophage Lambda Terminase and the Mechanism of Viral DNA Packaging
- DNA Packaging in Bacteriophage T4
- Bacteriophage SPP1 DNA Packaging
- Polyomavirus-associated Nephropathy in Renal Transplantation: Critical Issues of Screening and Management
- Entry of Herpesviruses into Cells: The Enigma Variations
Table 2Summary of cytoplasmic dynein 1 and dynactin subunit composition. Data for this table is summarized in refs. 4,8,166
| Motor Protein | Subunit | New Nomenclature167 | No. | Comments |
|---|---|---|---|---|
| Cytoplasmic | Heavy chain | 2 | Power generating unit | |
| Dynein 1 | DHC1a | DYNC1H1 | ||
| Intermediate chains IC-1A, B splicing isoforms IC-2A, B, C splicing isoforms | DYNC1I1 DYNC1I2 | 2 | IC proteins are the major scaffolding molecule of dynein complex. Multiple | |
| splicing isoforms exist. Bind DHC, light chains and dynactin subunit p150. | ||||
| Light intermediate chains | 2-4 | Several splicing | ||
| LIC1 | DYNC1LI1 | isoforms of LIC2 exist. | ||
| OR LIC2 | DYNC1LI2 | Both LICs bind DHC and can bind cargo. | ||
| Each complex contains either LIC1 or LIC2, but not both. | ||||
| Light chains Tctex 1 light chain 1 OR Tctex 1 light chain 3 (rp3) | DYNLT1 DYNLT3 | 4-5 | Some may be involved in cargo binding. | |
| Roadblock 1 (Rdbl1) | DYNLRB1 | |||
| OR Roadblock 2 (Rdbl2) | DYNLRB2 | |||
| LC8 light chain 1 | DYNLL1 | |||
| ORLC8 light chain 2 | DYNLL2 | |||
| Dynactin | p150Glued | 2 | Dimerisation mediated through coiled coils. The subunit binds dynein intermediate chain, p50, p25, p24 and Arp1 filament. | |
| p62 | 1 | Binds the -end of Arp1 filament, p25, p27, Arp1 and Arp11. Not necessary for dynactin stability. | ||
| Dynamitin (p50) | 4 | The subunits associate with each other p24 and p150. | ||
| Arp11 | 1 | Binds -end of Arp1 filament. | ||
| Arp1 | 8 | Can form short filaments and connects the dynactin complex with cargo. | ||
| β-actin | ? | Copurifies with dynactin complex. | ||
| CapZ α/β | 1 | Binds +end of Arp1 filament. | ||
| p24/p22 | 2 | Binds p150 and p50. | ||
| p27 | 1? | Loosely associated with dynactin complex. Also exists soluble in cytoplasm. | ||
| p25 | 1? |
- Adhesion Molecules
- Aging
- Angiogenesis
- Apoptosis
- Autophagy in Caenorhabditis elegans
- Apoptosis Dependent and Independent Functions of Caspases
- The Role of Caspases in Modulation of Cytokines and Other Molecules in Apoptosis and Inflammation
- Caspases, Bcl-2 Family Proteins and Other Components of the Death Machinery: Their Role in the Regulation of the Immune Response
- Learning from Deficiency: Gene Targeting of Caspases
- Caspase Activation in Cancer Therapy
- Caspase-Independent Cell Death Mechanisms
- Caspases as Targets for Drug Development
- In Situ Activation of Caspases Revealed by Affinity Labeling Their Enzymatic Sites
- Atherosclerosis
- Autoimmunity
- Targeting Antigen-Specific T Cells for Gene Therapy of Autoimmune Disease
- Cytokines in the Pathogenesis of Rheumatoid Arthritis and Collagen-Induced Arthritis
- Cytokines in the Treatment and Prevention of Autoimmune Responses
- Involvement of Cytokines in the Pathogenesis of Systemic Lupus Erythematosus
- Gene Therapy-Based Approach for Immune Tolerance Induction Using Recombinant Immunoglobulin Carriers
- Hematologic Diseases: Autoimmune Hemolytic Anemia and Immune Thrombocytopenic Purpura
- Gastroenterologic and Hepatic Diseases
- Inflammatory Myopathies: Dermatomyositis, Polymyositis and Inclusion Body Myositis
- Immunogene Therapy with Nonviral Vectors
- Cytokines and Chemokines in Autoimmune Disease: An Overview
- CTLA-4 in Type 1 Diabetes Mellitus
- 4-1BB as a Therapeutic Target for Human Disease
- NATURALLY OCCURRING ANTIBODIES AS THERAPEUTICS FOR NEUROLOGIC DISEASE: Can Human Monoclonal IgMs Replace the Limited Resource IVIg?
- Bioinformatics
- Biomaterials
- Biosurfactants
- Biotechnology
- Use of piggyBac and a Sindbis Virus for Foreign Gene Expression and RNAi in the Silkworm
- Molecular Properties of Voltage-Gated Calcium Channels
- Why Government Is the Problem (and What to Do about It)
- Transgenic Analysis of the Biological Functions of a Doublesex Homologue in Bombyx mori
- Carbon Nanostructures as a New High-Performance Platform for MR Molecular Imaging
- Foundations of E-Cell Simulation Environment Architecture
- Electrophysiological Simulation of Developmental Changes in Action Potentials of Cardiomyocytes
- Distributed Cell Biology Simulations with the E-Cell System
- Bacterial Vectors for RNAi Delivery
- HSV as a Vector in Vaccine Development and Gene Therapy
- Cancer Development
- Cancer Genetics
- Cancer Metastasis
- Integrins in Cancer Cell Invasion
- The Plasminogen Activation System in Cell Invasion
- Maspin: Functional Insights from a Structural Perspective
- Maspin and Pericellular Plasminogen Activation in Cell-Matrix Interaction
- Maspin Suppresses Breast Cancer Cell Invasiveness by Modulating Integrin Expression and Function
- The Role of Maspin in Tumor Progression and Normal Development
- The Role of Maspin in Human Placental Development
- Keratinocyte Interactions with Fibronectin during Wound Healing
- Sympathetic Nervous System Regulation of Metastasis
- Long Non-Coding RNA: Agent Provacateur in Breast Cancer Metastasis
- Investigating Metastasis Using In Vitro Platforms
- Modeling Metastasis In Vivo
- Cell Biology
- Intracellular Membrane Fusion
- The Golgi Apparatus
- Clathrin-Mediated Endocytosis
- Decoding the Signaling Mechanism of Toll-Like Receptor 4 Pathways in Wild Type and Knockouts
- Carrier Motility
- The Exocytic Pathway and Development
- Memory Th1/Th2 Cell Generation Controlled by Schnurri-2
- The “O” Class: Crafting Clinical Care with FoxO Transcription Factors
- FOXP Genes, Neural Development, Speech and Language Disorders
- Regulation and Coordination of Intracellular Trafficking: An Overview
- Overview of Intracellular Compartments and Trafficking Pathways
- Sumoylation as a Signal for Polyubiquitylation and Proteasomal Degradation
- Studies on the Very Large G Protein–Coupled Receptor From Initial Discovery to Determining Its Role in Sensorineural Deafness in Higher Animals
- Autosomal Lyonization of Replication Domains During Early Mammalian Development
- X Chromosome Inactivation and Embryonic Stem Cells
- NOTCH SIGNALING AND THE DEVELOPING HAIR FOLLICLE
- NOTCH SIGNALING AND THE GENERATION OF CELL DIVERSITY IN DROSOPHILA NEUROBLAST LINEAGES
- THE NEURAL BASIS OF SEMANTIC AND EPISODIC FORMS OF SELF-KNOWLEDGE: Insights from Functional Neuroimaging
- NOTCH SIGNALING AND THE DEVELOPING INNER EAR
- POLYALANINE TRACT DISORDERS AND NEUROCOGNITIVE PHENOTYPES
- NOTCH SIGNALING IN LUNG DEVELOPMENT AND DISEASE
- SELECTIVE NEURODEGENERATION, NEUROPATHOLOGY AND SYMPTOM PROFILES IN HUNTINGTON'S DISEASE
- Cell Cycle
- The Restriction Point of the Cell Cycle
- DNA Damage-Independent Checkpoints from Yeast to Man
- The Regulation of p53 Growth Suppression
- Functional Interactions Between BRCA1 and the Cell Cycle
- The Evolution of CDK-Activating Kinases
- CDK-Activating Kinases in Higher Plants
- Activating Phosphorylation of Cyclin-Dependent Kinases in Budding Yeast
- Cell Invasion
- Cell Metabolism
- Theory of Organelle Biogenesis: A Historical Perspective
- Microfibril-Associated Glycoprotein-1 (MAGP-1) and Other Non-fibrillin Macromolecules Which May Possess a Functional Association with the 10 nm Microfibrils
- Synaptic Endosomes
- Endocytosis of Receptor Tyrosine Kinases: Implications for Signal Transduction by Growth Factors
- Macroautophagy in Mammalian Cells
- Plant Lipocalins
- The Plasma Lipocalins α1-Acid Glycoprotein, Apolipoprotein D, Apolipoprotein M and Complement Protein C8γ
- Molecular Biology of the OXPHOS System
- Bacterial Lipocalins: Origin, Structure, and Function
- Chaperone-Mediated Autophagy
- Regulation of Paracellular Transport across Tight Junctions by the Actin Cytoskeleton
- Entry into the Endoplasmic Reticulum: Protein Translocation, Folding and Quality Control
- Tight Junction Proteins and Cancer
- Membrane Resealing Mediated by Lysosomal Exocytosis
- Transcriptional Regulation of Keratin Gene Expression
- Lysosomal Proteases: Revival of the Sleeping Beauty
- Preprotein Translocation through the Sec Translocon in Bacteria
- Molecular Basis of Oncogenesis by NF-κB: From a Bird's Eye View to a RELevant Role in Cancer
- Nuclear Import of Agrobacterium T-DNA
- Keratins As Targets in and Modulators of Liver Diseases
- Retinol Binding Protein and Its Interaction with Transthyretin
- Keratin Intermediate Filaments and Diseases of the Skin
- Important Mammalian Respiratory Allergens Are Lipocalins
- Lipocalin Receptors: Into the Spotlight
- α1-Microglobulin
- Lipocalins in Clinical Medicine
- Lysosomal Storage Disorders
- Lipocalins in Arthropoda: Diversification and Functional Explorations
- Lipocalin-Type Prostaglandin D Synthase as an Enzymic Lipocalin
- Glycodelin: A Lipocalin with Diverse Glycoform-Dependent Actions
- Nonsecretory, Regulated Exocytosis: A Multifarious Mechanism Employed by Cells to Carry Out a Variety of Functions
- Protein Misassembly: Macromolecular Crowding and Molecular Chaperones
- Molecular Interaction Network of the Hsp90 Chaperone System
- The Synapsins and the Control of Neuroexocytosis
- Hsp90 and Developmental Networks
- A Common Binding Site for Actin-Binding Proteins on the Actin Surface
- The Role of Synaptotagmin and Synaptotagmin-Like Protein (Slp) in Regulated Exocytosis
- Cell-Free Synthesis of Defined Protein Conjugates by Site-directed Cotranslational Labeling
- Reverse Engineering Models of Cell Cycle Regulation
- Nuclear Import of Plant Proteins
- Dynamic Connections of Nuclear Envelope Proteins to Chromatin and the Nuclear Matrix
- Nuclear Envelope Dynamics in Drosophila Pronuclear Formation and in Embryos
- Nuclear Envelope Breakdown and Reassembly in C. elegans: Evolutionary Aspects of Lamina Structure and Function
- Laminopathies: One Gene, Two Proteins, Five Diseases..
- Dynamics of Nuclear Envelope Proteins During the Cell Cycle in Mammalian Cells
- Calnexin and Calreticulin, Molecular Chaperones of the Endoplasmic Reticulum
- Calreticulin-Mediated Nuclear Protein Export
- Calreticulin and the Endoplasmic Reticulum in Plant Cell Biology
- Calnexin and Calreticulin, ER Associated Modulators of Calcium Transport in the ER
- ER Calcium and ER Chaperones: New Players in Apoptosis?
- Calreticulin in Cytotoxic Lymphocyte-Mediated Cytotoxicity
- A Role for Calreticulin in the Clearance of Apoptotic Cells and in the Innate Immune System
- Calreticulin and Tumor Suppression
- Cell Surface Calreticulin: Role in Signaling Thrombospondin Anti-Adhesive Activity
- Calreticulin Regulation of Lung Endothelial NOS Activity
- Channels and Transporters
- Cell-Cell Fusion: Transient Channels Leading to Plasma Membrane Merger
- Anion Conduction by CFTR: Mechanisms and Models
- Voltage-Dependent Inactivation of Voltage Gated Calcium Channels
- A Brief History of Calcium Channel Discovery
- Biochemical Studies of Voltage-Gated Ca2+ Channels
- Block of Voltage-Gated Calcium Channels by Peptide Toxins
- Calcium Channel Block and Inactivation: Insights from Structure-Activity Studies
- Ca2+ Chemistry, Storage and Transport in Biologic Systems: An Overview
- Hepatic Copper Transport
- Drug-Induced Cholestatic Liver Disease
- Cell-Cell Channels and Their Implications for Cell Theory
- Cytoplasmic Bridges in Volvox and Its Relatives
- Gap Junctions: Cell-Cell Channels in Animals
- The Tetrahymena Conjugation Junction
- Mating Cell-Cell Channels in Conjugating Bacteria
- Fusome as a Cell-Cell Communication Channel of Drosophila Ovarian Cyst
- Channels across Endothelial Cells
- Cytonemes as Cell-Cell Channels in Human Blood Cells
- Vegetative Hyphal Fusion in Filamentous Fungi
- Fat Absorption and Lipid Metabolism in Cholestasis
- Genetics, Mutations, and Polymorphisms
- Hepatocyte Transplantation and Liver-Directed Gene Therapy
- Phylogeny of Major Intrinsic Proteins
- Chaperones
- Circadian Rhythms
- Coagulation
- Regulation of Tissue Factor Expression
- Factor XI, TAFI and DIC
- Cytokines as Regulators of Coagulation
- DIC at the Intersection of the Thrombotic, Fibrinolytic and Inflammatory Axes
- Genetic Risk Factors for Disseminated Intravascular Coagulation
- Endothelial Cell Perturbation and Disseminated Intravascular Coagulation
- Blood-Borne Tissue Factor (Including Microparticles)
- Cytokines/Growth Factors
- Development
- Embryonic Salivary Gland Branching Morphogenesis
- Integrins and Development: Integrins in Skeletal Cell Function and Development
- Membrane Lipid Rafts and Their Role in Axon Guidance
- Epithelial-Mesenchymal Transformation in the Embryonic Heart
- GSK3-Signal Regulation of Pattern Formation in Dictyostelium: Wnt-Like Pathways During Non-Canonical Multicellular Development
- Functional and Ecological Effects of Isoform Variation in Insect Flight Muscle
- Change of Epithelial Fate: Lessons from Gastrulation in Drosophila
- Cadherin-Mediated Cell-Cell Adhesion and the Microtubule Network
- TGFβ-dependent Epithelial-Mesenchymal Transition
- Branching Morphogenesis of the Prostate
- Expression and Function of Pitx2 in Chick Heart Looping
- Neural Crest and the Development of the Enteric Nervous System
- Matrix Metalloproteases and Epithelial-to-Mesenchymal Transition: Implications for Carcinoma Metastasis
- Whole Genome Approaches to Studying Drosophila Muscle Development
- Muscle Morphogenesis: The Process of Embryonic Myoblast Fusion
- Development of the Larval Somatic Musculature
- The Pathophysiological Role of Impaired Calcium Handling in Muscular Dystrophy
- X-Ray Diffraction of Indirect Flight Muscle from Drosophila in Vivo
- The Sarcoglycans
- The Role of Insulin-like Growth Factors in the Epithelial to Mesenchymal Transition
- Epithelium–Mesenchyme Transitions Are Crucial Morphogenetic Events Occurring During Early Development
- How Is the Branching of Animal Blood Vessels Implemented?
- Integrins and Associated Proteins in Drosophila Development
- Roles for Integrins and Associated Proteins in the Haematopoietic System
- Development of the Cardiac Musculature
- Shh/Gli Signaling During Murine Lung Development
- New Perspectives in Shh Signalling?
- Role of shh and Gli Signalling in Oligodendroglial Development
- Branching Morphogenesis in Vertebrate Neurons
- Sonic Hedgehog Signaling in the Developing and Regenerating Fins of Zebrafish
- Role of Hedgehog and Gli Signalling in Telencephalic Development
- Structure and Function of the Dystrophin-Glycoprotein Complex
- Caveolin-3 and Limb-Girdle Muscular Dystrophy
- Lamins and Emerin in Muscular Dystrophy: The Nuclear Envelope Connection
- Cranial Neural Crest and Development of the Head Skeleton
- Mesoderm Formation in the Drosophila Embryo
- Neural Crest Delamination and Migration: Integrating Regulations of Cell Interactions, Locomotion, Survival and Fate
- Insect Flight Muscle Chemomechanics
- The Role of Integrins in Cell Migration
- Neural Crest Cell Plasticity: Size Matters
- Neural Crest Stem Cells
- Integrins: An Overview of Structural and Functional Aspects
- An Evolutionary Perspective on Eukaryotic Membrane Trafficking
- Slits and Their Receptors
- Origins and Evolution of Cotranslational Transport to the ER
- Origins and Evolution of the Actin Cytoskeleton
- Comparison of Muscle Development in Drosophila and Vertebrates
- Neural Crest Cells and the Community of Plan for Craniofacial Development: Historical Debates and Current Perspectives
- The Genetic Regulation of Pigment Cell Development
- Origin and Evolution of Self-Consumption: Autophagy
- The Contribution of the Neural Crest to the Vertebrate Body
- Dorsoventral Patterning of the Brain: A Comparative Approach
- VEGF and Endothelial Guidance in Angiogenic Sprouting
- CtBP and Hematopoietic Transcriptional Regulators
- A New Member of the CtBP/BARS Family from Plants: Angustifolia
- Simulation of Human Erythrocyte Metabolism
- A Model Library of Bacterial Chemotaxis on E-Cell System
- CtBP3/BARS and Membrane Fission
- Hsp70-Mediated Protein Refolding in E-Cell
- VEGF Receptor Signalling in Vertebrate Development
- Vascular and Nonvascular Roles of VEGF in Bone Development
- Morphogenesis of Epithelial Appendages: Variations on Top of a Common Theme and Implications in Regeneration
- Wnt/Wingless Signaling in Drosophila
- The Role of Wnt Signaling in Vertebrate Head Induction and the Organizer-Gradient Model Dualism
- The Wnt Gene Family and the Evolutionary Conservation of Wnt Expression
- Secreted Antagonists/Modulators of Wnt Signaling
- Patterning the Vertebrate Neural Plate by Wnt Signaling
- Wnt/Wg and Heart Development
- Wnt Signaling and Cell Migration
- DNA Surveillance and Repair
- Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity
- PARP and the Release of Apoptosis-Inducing Factor from Mitochondria
- DNA Damage Signaling through Poly(ADP-Ribose)
- Dynamic Interaction between PARP-1, PCNA and p21waf1/cip1
- Parp and Epigenetic Regulation
- Genome Degradation by DNAS1L3 Endonuclease: A Key PARP-1-Regulated Event in Apoptosis
- Role of Poly-ADP-Ribosylation in Cancer Development
- The Fanconi Anemia/BRCA Pathway: FANCD2 at the Crossroad between Repair and Checkpoint Responses to DNA Damage
- Fluorescence-Signaling Nucleic Acid-Based Sensors
- Trichothiodystrophy: A Disorder Highlighting the Crosstalk between DNA Repair and Transcription
- Mobile Genetic Elements of Malaria Vectors and Other Mosquitoes
- Orchestration of Telomeres and DNA Repair Factors in Mammalian Cells: Implications for Cancer and Ageing
- Mechanisms of DNA Damage and Repair in Alzheimer Disease
- Origin, Recognition, Signaling and Repair of DNA Double-Strand Breaks in Mammalian Cells
- The Tn4371 ICE Family of Bacterial Mobile Genetic Elements
- The Tn916/Tn1545 Family of Conjugative Transposons
- Restriction-Modification Systems as Mobile Epigenetic Elements
- DNA Vaccines
- Drug Design
- Endocrinology
- Regulation of Insulin Action and Insulin Secretion by SNARE-Mediated Vesicle Exocytosis
- Subcellular Compartmentalization of Insulin Signaling Processes and GLUT4 Trafficking Events
- Insulin Action in the Islet β-Cell
- What Is Osteoporosis?
- Insulin and IGF-I Receptor Structure and Binding Mechanism
- Insulin Resistance
- Insulin Action Gene Regulation
- Evolution
- Ribozyme-Catalyzed Genetics
- Origin and Evolution of DNA and DNA Replication Machineries
- Life in a Tenuous Universe
- The Frame for New Hypotheses of Evolution
- Genomism and the Nature Trail
- The Origin of Complexity
- Our Young Planet: One Is Not a Choice
- The Condensation of Life
- The Origins of Species
- Development of Biological Potential
- Thoughts on Multi-Cellularity: How Nature Got Around Darwin
- Natura non facit saltum (Nature does nothing in jumps)
- The Invariance Concept
- On the Evolution of Humans
- Molecular Geneology
- Experiments in Evolution
- Quintessence
- The Scope of Selection
- Extracellular Matrix
- Gastroenterology
- Functional Heterogeneity of the Intrahepatic Biliary Epithelium
- Bile Acid Interactions with Cholangiocytes
- Estrogen Regulation of Cholangiocyte Proliferation
- Nerve Regulation of Cholangiocyte Functions
- Vascularization of the Intrahepatic Biliary Tree and Its Role in the Regulation of Cholangiocyte Growth
- Cytokine Regulation of Cholangiocyte Growth
- Hyperemesis Gravidarum and Maternal Liver Disease
- The Liver in Normal Pregnancy
- Spectrum of Maternal Liver Disease
- Gene Expression
- Stochastic Gene Expression: Dominance, Thresholds and Boundaries
- Biological Consequences of Dosage Dependent Gene Regulation in Multicellular Eukaryotes
- GAGA: Structural Basis for Single Cys2His2 Zinc Finger-DNA Interaction
- Identification of Mammalian E2F Regulatory Networks Using DNA Microarray Hybridization Analyses
- Homing Endonuclease I-TevI: An Atypical Zinc Finger with a Novel Function
- A Novel Test Statistic for the Identification of Local Selective Sweeps Based on Microsatellite Gene Diversity
- Periodic Selection and Ecological Diversity in Bacteria
- LIM Domain and Its Binding to Target Proteins
- Inferring Evolutionary History through Inter- and Intraspecific DNA Sequence Comparison: The Drosophila janus and ocnus Genes
- Selective Sweep in the Evolution of a New Sperm-Specific Gene in Drosophila
- The Superfamily of SCAN Domain Containing Zinc Finger Transcription Factors
- Putative Roles of kin17, a Mammalian Protein Binding Curved DNA, in Transcription
- CtBP Family Proteins: Unique Transcriptional Regulators in the Nucleus with Diverse Cytosolic Functions
- A Zinc Ribbon Motif Is Essential for the Formation of Functional Tetrameric Protein Kinase CK2
- Rapid Evolution of Sex-related Genes: Sexual Conflict or Sex-specific Adaptations?
- Repression of Transcription by Curved DNA and Nucleoid Protein H-NS: A Mode of Bacterial Gene Regulation
- Curved DNA and Transcription in Eukaryotes
- PNA and Oligonucleotide Inhibitors of Human Telomerase
- Possible Roles of DNA Supercoiling in Transcription
- MDM2: RING Finger Protein and Regulator of p53
- Gene Regulatory Networks
- Do DNA Triple Helices or Quadruplexes Have a Role in Transcription?
- The Biology of Telomeres in Hypotrichous Ciliates
- Scaling Laws in the Functional Content of Genomes: Fundamental Constants of Evolution?
- Regulation of Cardiomyocyte Proliferation and Apoptosis
- Cell Cycle Reactivation in Skeletal Muscle and Other Terminally Differentiated Cells
- The Role of Unusual DNA Structures in Chromatin Organization for Transcription
- Molecular Mechanisms of Male Sex Determination: The Enigma of SRY
- DNA: Alternative Conformations and Biology
- Curved DNA and Prokaryotic Promoters: A Mechanism for Activation of Transcription
- Scale-Free Evolution: From Proteins to Organisms
- Bioinformatics: Mystery, Astrology or Service Technology?
- Extracting Information for Meaningful Function Inference Through Text-Mining
- Microarrays and Gene Regulation Networks in Yeast
- Transcriptional Repression by the CtBP Corepressor in Drosophila
- Structural Determinants of CtBP Function
- Analytical Evolutionary Model for Protein Fold Occurrence in Genomes, Accounting for the Effects of Gene Duplication, Deletion, Acquisition and Selective Pressure
- Power Law Correlations in DNA Sequences
- Transcriptional Networks in Mammalian Gene Regulation
- DNA Primer Extension by Telomerase
- Transcriptional Profiling of the Hepatic Growth Response
- Expression of Hox Genes in the Nervous System of Vertebrates
- Telomeres: Guardians of Genomic Integrity or Double Agents of Evolution?
- Alternative Lengthening of Telomeres in Mammalian Cells
- Evolution of Telomere Binding Proteins
- Drosophila Telomeres: A Variation on the Telomerase Theme
- Telomerase Activity as a Marker of Tumor Cell Survival to Evaluate Sensitivity of Neoplastic Cells to Cancer Treatment
- Myotonic Dystrophy: Discussion of Molecular Basis
- Roles for TERT and Telomerase in Cell Differentiation and Apoptosis
- Molecular Mechanisms of TRS Instability
- Yeast Telomerases: Structure, Mechanisms and Regulation
- The Significance of Quantitative Evaluation of Telomerase Activity and hTERT mRNA Expression in Colorectal Cancers
- Human, Mouse and Yeast Telomerase
- Telomerase in Mesothelioma: Diagnostic and Therapeutic Applications
- Telomerase Activity in Neuroblastomas: A New Molecular Marker for Treatment Stratification and Prognostic Grouping
- Telomerase and Radiosensitivity of Human Tumors
- Heart
- Heat Shock Proteins
- Hematology
- Immunology
- Animal Models of OXPHOS Disorders
- Molecular Recognition of Haptens by T Cells: More Than One Way to Tickle the Receptor
- Phospholipases and Phagocytosis
- IgA and Mucosal Homeostasis
- Carbohydrate-Based Targets and Vehicles for Cancer and Infectious Diseases Vaccines
- Small GTP Binding Proteins and the Control of Phagocytic Uptake
- Calcium Signaling During Phagocytosis
- Regulation of Phagocytosis by FcγRIIb and Phosphatases
- Adding Complexity to Phagocytic Signaling: Phagocytosis-Associated Cell Responses and Phagocytic Efficiency
- V(D)J Recombination: Of Mice and Sharks
- Opioid Receptors on Peripheral Sensory Neurons
- Morphological Correlates of Immune-Mediated Peripheral Opioid Analgesia
- Functional Evidence of Pain Control by the Immune System
- Opioid Receptor Expression and Intracellular Signaling by Cells Involved in Host Defense and Immunity
- Experimental Evidence for Immunomodulatory Effects of Opioids
- The Immune-Suppressive Effects of Pain
- Lipoxins as an Immune-Escape Mechanism
- Dynamic Aspects of TCRα Gene Recombination: Qualitative and Quantitative Assessments of the TCRα Chain Repertoire in Man and Mouse
- Viral TNF Inhibitors as Potential Therapeutics
- CD8 T-Cell Memory Differentiation during Acute and Chronic Viral Infections
- Chromatin Mechanisms Regulating Gene Expression In Health And Disease
- Earthworm Immunity
- TRIM PROTEINS AS RING FINGER E3 UBIQUITIN LIGASES
- REGULATORS OF CA2+ SIGNALING IN MAST CELLS Potential Targets for Treatment of Mast-Cell Related Diseases?
- GASTROPOD IMMUNOBIOLOGY
- MAST CELLS AND IMMUNOREGULATION/IMMUNOMODULATION
- MAST CELL PROTEASES AS PROTECTIVE AND INFLAMMATORY MEDIATORS
- Innate Immune Evasion Strategies of HCV and HIV: Common Themes for Chronic Viral Infection
- Infectious Disease
- Everything (or Almost Everything) You Want to Know about Genetically Modified Mosquitoes for Malaria Control but Are (Maybe) Afraid to Ask
- Predicting the Spread of a Transgene in African Malaria Vector Populations: Current Knowledge and Limitations
- Invasion and Intracellular Survival by Toxoplasma
- Negative Signaling and Modulation of Macrophage Function in Trypanosoma cruzi Infection
- Pro-Inflammatory Responses in Macrophages during Toxoplasma gondii Infection
- Avoidance of Innate Immune Mechanisms by the Protozoan Parasite, Leishmania spp
- Insect Population Suppression Using Engineered Insects
- Current and Emerging Approaches to Studying Invasion in Apicomplexan Parasites
- CATHEPSIN PROTEASES IN TOXOPLASMA GONDII
- Ischemia-Reperfusion
- Medical
- Mitochondria
- Molecular Biology
- Gas7
- RNA Modification Subsystems in the SEED Database
- KIR Genes and Their Role in Spondyloarthropathies
- Antibiotic Resistance in Bacteria Caused by Modified Nucleosides in 23S Ribosomal RNA
- The “PACE” Concept Pointed at New Key Proteins Involved in RNA Metabolism
- DNA Demethylation
- Adhesion-Dependent Modulation of Macrophage K+ Channels
- Pseudouridine Formation, the Most Common Transglycosylation in RNA
- Folate-Dependent Thymidylate-Forming Enzymes: Parallels between DNA and RNA Metabolic Enzymes and Evolutionary Implications
- The Interplay between RNA and DNA Modifications: Back to the RNA World
- Deciphering the Complex Enzymatic Pathway for Biosynthesis of Wyosine Derivatives in Anticodon of tRNAPhe
- Nucleic Acids Are Not Boring Long Polymers of Only Four Types of Nucleotides: A Guided Tour
- Chemokine Binding Proteins Encoded by Pathogens
- Boomerangs, Bananas and Blimps: Structure and Function of F-BAR Domains in the Context of the BAR Domain Superfamily
- Enzyme-RNA Substrate Recognition in RNA-Modifying Enzymes
- Nanomedicine
- Neurodegenerative Disease
- DSD-1-Proteoglycan/Phosphacan and Receptor Protein Tyrosine Phosphatase-Beta Isoforms During Development and Regeneration of Neural Tissues
- Interleukin-10 and Psoriasis
- Idiopathic Parkinson's Disease: Staging an α-Synucleinopathy with a Predictable Pathoanatomy
- Chromosome 1 and Other Hotspots for Parkinson's Disease Genes
- Fibroblast Growth Factors
- Neuronal Survival and Cell Death Signaling Pathways
- Paved with Good Intentions: The Link between Cell Cycle and Cell Death in the Mammalian Central Nervous System
- α-Synuclein Physiology and Membrane Binding
- Na Channels and Ca2+ Channels of the Cell Membrane as Targets of Neuroprotective Substances
- Heat Shock Proteins and Neuroprotection
- Blood-Brain Barrier Drug Targeting Enables Neuroprotection in Brain Ischemia Following Delayed Intravenous Administration of Neurotrophins
- Neuroprotective Strategies in Animal and in Vitro Models of Neuronal Damage: Ischemia and Stroke
- Vascular Endothelial Growth Factor
- Cell Cycle and Chromosome Segregation Defects in Alzheimer's Disease
- Neuroprotective Activity of Metabotropic Glutamate Receptor Ligands
- Excitatory Amino Acid Neurotoxicity
- Dopamine and Parkinson's Disease
- Neurotrophins
- Overview Αβ Metabolism: From Alzheimer Research to Brain Aging Control
- β-Secretase: Progress and Open Questions
- APP α-Secretase, a Novel Target for Alzheimer Drug Therapy
- γ-Secretase and Presenilin
- Functional Roles of APP Secretases
- Proteolytic Degradation of Αβ by Neprilysin and Other Peptidases
- Αβ Degradation by Endothelin-Converting Enzymes
- Ab Metabolism in Cholesterol-Enriched Membrane Microdomains
- Amyloid β-Protein in Low-Density Membrane Domains
- Transport-Clearance Hypothesis for Alzheimer's Disease and Potential Therapeutic Implications
- Potential Role of Endogenous and Exogenous Ab Binding Molecules in Ab Clearance and Metabolism
- Modulating Amyloid β Levels by Immunotherapy: A Potential Therapeutic Strategy for the Prevention and Treatment of Alzheimer's Disease
- Neuropharmacology
- Diurnal 5-HT Production and Melatonin Formation
- Pineal Gland and Cancer—An Epigenetic Approach to the Control of Malignancy: Evaluation of the Role of Melatonin
- Cell Adhesion Molecules
- Risks of Chronic Hypnotic Use
- Sleep Hippocampal Theta Rhythm and Sensory Processing
- Cannabinoid Receptors and Signal Transduction
- Protein Kinase A
- A Comparison of Visual Analog Scale and Categorical Ratings in Assessing the Patient's Estimate of Sleep Quality
- Neuroscience
- Nucleus
- Oncogenes
- Oncology
- Fever, Pyrogens and Cancer
- Gene Expression Profiling in Malignant Lymphomas
- Cytoreduction, Peritonectomy and Hyperthermic Antiblastic Peritoneal Perfusion for the Treatment of Peritoneal Carcinomatosis
- Hyperthermic Isolated Limb Perfusion
- Intracavitary Hyperthermic Perfusion
- Locoregional Hyperthermia
- Transcription of rDNA in the Yeast Saccharomyces cerevisiae
- Pre-Ribosomal RNA Processing in Multicellular Organisms
- PDGF Pathways and Growth of Basal Cell and Squamous Cell Carcinomas
- Extreme Whole-Body Hyperthermia with Water-Filtered Infrared-A Radiation
- Influence of Tumor Microenvironment on Thermoresponse: Biologic and Clinical Implications
- Physical Background and Technical Realizations of Hyperthermia
- Effects of Local and Whole Body Hyperthermia on Immunity
- Thermo-Chemo-Radiotherapy Association: Biological Rationale, Preliminary Observations on Its Use on Malignant Brain Tumors
- Molecular Mechanisms of ErbB2-Mediated Breast Cancer Chemoresistance
- Future Perspectives of Interstitial and Perfusional Hyperthermia
- Roles of Multidrug Resistance Genes in Breast Cancer Chemoresistance
- Insulin-Like Growth Factors and Breast Cancer Therapy
- Novel Approaches for Chemosensitization of Breast Cancer Cells: The E1A Story
- Whole Body Hyperthermia at 43.5-44°C: Dreams or Reality?
- Overview of Resistance to Systemic Therapy in Patients with Breast Cancer
- Microarrays for Cancer Diagnosis and Classification
- Monophosphoryl Lipid A (MPL) as an Adjuvant for Anti-Cancer Vaccines: Clinical Results
- Cellular Interactions in Nasopharyngeal Carcinomas
- Protein
- Structure, Function and Assembly of Flagellar Axial Proteins
- Implications of 3D Domain Swapping for Protein Folding, Misfolding and Function
- From Artificial Antibodies to Nanosprings:The Biophysical Properties of Repeat Proteins
- The Budding Yeast PCH/F-BAR Proteins
- The Coronin Family of Proteins
- Diversity of WD-repeat Proteins
- A Brief History of the Coronin Family
- Phylogenetic, Structural and Functional Relationships between WD-and Kelch-Repeat Proteins
- The Role of Mammalian Coronins in Development and Disease
- Invertebrate Coronins
- Evolutionary and Functional Diversity of Coronin Proteins
- Coronin: The Double-Edged Sword of Actin Dynamics
- Coronin 1 in Innate Immunity
- Molecular Phylogeny and Evolution of the Coronin Gene Family
- Coronin Structure and Implications
- Nuclear APC
- Role of Mammalian Coronin 7 in the Biosynthetic Pathway
- Post-Targeting Functions of Signal Peptides
- STRUCTURAL DISORDER AND PROTEIN ELASTICITY
- Reproductive Biology
- Splitting Hairs: Dissecting the Roles of Gli Activator and Repressor Functions during Epidermal Development and Disease
- Bi-Directional Cell Trafficking During Pregnancy: Long-term Consequences for Human Health
- Immunology and Pregnancy Losses: HLA, Autoantibodies and Cellular Immunity
- The Role of Corticotropin-Releasing Hormone (CRH) on Implantation and Immunotolerance of the Fetus
- Characterization of Human Dendritic Cells at the Maternal-Fetal Interphase
- Important Role of Shh Controlling Gli3 Functions During the Dorsal-Ventral Patterning of the Telencephalon
- Spatial and Temporal Regulation of Hair Follicle Progenitors by Hedgehog Signalling
- MHC Molecules of the Preimplantation Embryo and Trophoblast
- The Role of Regulatory T Cells in Materno-Fetal Tolerance
- Cytogenetics of Human Sperm
- Preimplantation Genetic Diagnosis (PGD): Screening for Aneuploidy in Human Oocytes and Polar Bodies
- Proteases and Their Cognate Inhibitors of the Serine and Metalloprotease Subclasses, in Testicular Physiology
- Antioxidant Systems and Oxidative Stress in the Testes
- RNA
- Protein-Switched Ribozymes
- Proteins Carrying One or More Unnatural Amino Acids
- Therapies of Nonsense-Associated Diseases
- All Termination Events Are Not Equal: Premature Termination in Yeast Is Aberrant and Triggers NMD
- Role of SMG-1-mediated Phosphorylation of Upf1 in NMD
- NMD in Drosophila: A Snapshot into the Evolution of a Conserved mRNA Surveillance Pathway
- The snoRNPs and Related Machines: Ancient Devices That Mediate Maturation of rRNA and Other RNAs
- Trytophanyl-tRNA Synthetases
- Tyrosyl-tRNA Synthetases
- Cytokines, Chemokines and Their Receptors
- Valyl-tRNA Synthetases
- Protein-Induced RNA Switches in Nature
- Class I Lysyl-tRNA Synthetases
- Glutaminyl-tRNA Synthetases
- Asparaginyl-tRNA Synthetases
- Protein Tagging and Ribosome Rescue in Bacteria Requires the Recognition of Transfer-Messenger RNA by an Aminoacyl-tRNA Synthetase
- Aminoacyl-tRNA Synthetases and Disease
- Human Upf Proteins in NMD
- Phenylalanyl-tRNA Synthetases
- Regulation of Gene Expression by Coupling of Alternative Splicing and NMD
- NMD and Human Disease
- Polyadenylation and Degradation of RNA in Prokaryotes
- Regulation of the Expression of Aminoacyl-tRNA Synthetases and Translation Factors
- Conformational Dynamics within the Ribosome
- Tests of a Stereochemical Genetic Code
- Evasion of Phagosome Lysosome Fusion and Establishment of a Replicative Organelle by the Intracellular Pathogen Legionella pneumophila
- The End in Sight: Poly(A), Translation and mRNA Stability in Eukaryotes
- Recoding: Site- or mRNA-Specific Alteration of Genetic Readout Utilized for Gene Expression
- Mechanism of Translation Initiation in Eukaryotes
- A Prelude to Translational (Re)Initiation
- Mitochondrial Aminoacyl-tRNA Synthetases
- Transfer RNA Structure and Identity
- Post-Transcriptional Gene Silencing in Plants
- Turnover of Mature miRNAs and siRNAs in Plants and Algae
- miRNAs need a Trim Regulation of miRNA Activity by Trim-NHL Proteins
- Structural Components and Architectures of RNA Exosomes
- C. ELEGANS STAR PROTEINS, GLD-1 AND ASD-2, REGULATE SPECIFIC RNA TARGETS TO CONTROL DEVELOPMENT
- SPLICEOSOMAL RNA INFRASTRUCTURE: The Network of Splicing Components and their Regulation by miRNAs
- HOW OLD ARE RNA NETWORKS?
- THE RNA INFRASTRUCTURE: An Introduction to ncRNA Networks
- RNA NETWORKS IN PROKARYOTES I: CRISPRs and Riboswitches
- RNA NETWORKS IN PROKARYOTES II: tRNA Processing and Small RNAs
- PROMOTER-ASSOCIATED LONG NONCODING RNAs REPRESS TRANSCRIPTION THROUGH AN RNA BINDING PROTEIN TLS
- RNA BINDING DOMAINS AND RNA RECOGNITION BY RNA-EDITING MACHINERIES
- RNA-BINDING PROTEINS IN FUNGI AND THEIR ROLE IN mRNA LOCALIZATION
- FROM STRUCTURE TO FUNCTION OF RNA BINDING DOMAINS
- Signal Transduction
- Genetic Susceptibility to Infectious Diseases Linked to NRAMP1 Gene in Farm Animals
- FasL-Independent Activation of Fas
- Plant Metal Transporters with Homology to Proteins of the NRAMP Family
- Regulation of Bacterial MntH Genes
- Physiological Roles and Mechanisms of Signaling by TRAF2 and TRAF5
- Metal-ion Transporters— From Yeast to Human Diseases
- The Function of Toll-Like Receptors
- Regulation of the RhoGTPases by RhoGDI
- How the Hedgehog Outfoxed the Crab: Interference with HEDGEHOG-GLI Signaling as Anti-Cancer Therapy?
- Rho Family GTPases and Cellular Transformation
- GLI Genes and Their Targets in Epidermal Development and Disease
- Regulation of Cell Motility by Abl Family Kinases
- The Patched Receptor: Switching On/Off the Hedgehog Signaling Pathway
- Shh Expression in Pulmonary Injury and Disease
- Regulation of Cell Adhesion Responses by Abl Family Kinases
- Abl Family Kinases in Mammalian Development
- Abl and Cell Death
- Mechanisms of Activation of Abl Family Kinases
- Regulation of Cytoskeletal Dynamics and Cell Morphogenesis by Abl Family Kinases
- TRAFs in RANK Signaling
- Abelson Family Protein Tyrosine Kinases and the Formation of Neuronal Connectivity
- The LTβR Signaling Pathway
- Neurons, Neurotrophins and Ceramide Signaling: Do Domains and Pores Contribute to the Dichotomy?
- The Role of Serine/Threonine Protein Phosphatases in Ceramide Signaling
- Chaperone Effects on Prion and Nonprion Aggregates
- Insights into the Modulation of Ceramide Metabolism by Naturally Occurring and Synthetic Sphingolipid Analogs as Monitored by Electrospray Tandem Mass Spectrometry
- Ceramide Glycosylation and Chemotherapy Resistance
- S-Modulin
- Regulation of Voltage-Sensitive Ca2+ Channels in Bipolar Cells by Divalent Cations and Polyamines
- Target Recognition of Guanylate Cyclase by Guanylate Cyclase-Activating Proteins
- Centrins, a Novel Group of Ca2+-Binding Proteins in Vertebrate Photoreceptor Cells
- The TRP Calcium Channel and Retinal Degeneration
- Ca2+-dependent Control of Rhodopsin Phosphorylation: Recoverin and Rhodopsin Kinase
- The Complex of cGMP-gated Channel and Na/Ca2+, K Exchanger in Rod Photoreceptors
- RGS9-1 Phosphorylation and Ca2+
- Ceramide in the Regulation of Neuronal Development: Two Faces of a Lipid
- Therapeutic Implications of Ceramide-Regulated Signaling Cascades
- Photoreceptor Degeneration and Ca2+ Influx through Light-Activated Channels of Drosophila
- Regulation of the Rod Photoreceptor Cyclic Nucleotide-Gated Channel
- Mouse Models to Study GCAP Functions in Intact Photoreceptors
- Using Mutant Mice to Study the Role of Voltage-Gated Calcium Channels in the Retina
- Calcium Channels at the Photoreceptor Synapse
- Biosynthesis of Sphingolipids in Plants (and Some of Their Functions)
- Ceramide 1-Phosphate in Cell Survival and Inflammatory Signaling
- MSK1 and Nuclear Receptors Signaling
- Stimuli That Activate MSK in Cells and the Molecular Mechanism of Activation
- Stem Cells
- Tissue Engineering
- Scleroderma Lung Fibroblasts: Contractility and Connective Tissue Growth Factor
- Repair of Osteochondral Lesions
- Regulatory Issues: Down to the Bare Bones
- Anatomy and Physiology of the Spinal Cord
- Encouraging Regeneration of Host Neurones: The Use of Peripheral Nerve Bridges, Glial Cells or Biomaterials
- Replacement of Specific Neuronal Populations in the Spinal Cord
- Replacement of Specific Populations of Cells: Glial Cell Transplantation into the Spinal Cord
- In Vitro Endothelialization: Its Contribution Towards an Ideal Vascular Replacement
- Biocompatibility of Polyurethanes
- Tissue Repair in Asthma: The Origin of Airway Subepithelial Fibroblasts and Myofibroblasts
- Functional Assessment of Fibroblast Heterogeneity by the Cell-Surface Glycoprotein Thy-1
- Pro-Invasive Molecular Cross-Signaling between Cancer Cells and Myofibroblasts
- Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinase and Matrix Turnover and the Fate of Hepatic Stellate Cells
- Transplant
- Vaccines
- Viruses
- A Role for Chemokine Activity in Alphavirus Pathogenesis: Evidence from the Analysis of Polyarthritis and Myalgia Post-Ross River Virus Infection
- Evolutionary Aspects of Human Endogenous Retroviral Sequences (HERVs) and Disease
- Structure and Replication of Hepatitis Delta Virus RNA
- Hepatitis Delta Virus RNA Editing
- Hepatitis Delta Antigen and RNA Polymerase II
- Transforming Activities of JC Virus Early Proteins
- DNA Packaging by Bacteriophage P22
- Regulation of T Cell Immunity by OX40 and OX40L
- BK Virus, JC Virus and Simian Virus 40 Infection in Humans, and Association with Human Tumors
- The ø29 DNA Packaging Motor: Seeking the Mechanism
- Phylogenomics and Molecular Evolution of Polyomaviruses
- Urine Cytology Findings of Polyomavirus Infections
- Immunity and Autoimmunity Induced by Polyomaviruses: Clinical, Experimental and Theoretical Aspects
- Soluble Chemokine Binding Proteins Encoded by Viruses
- Bacteriophage Lambda Terminase and the Mechanism of Viral DNA Packaging
- DNA Packaging in Bacteriophage T4
- Bacteriophage SPP1 DNA Packaging
- Polyomavirus-associated Nephropathy in Renal Transplantation: Critical Issues of Screening and Management
- Entry of Herpesviruses into Cells: The Enigma Variations
Madame Curie Bioscience Database [Internet].
Austin (TX): Landes Bioscience; 2000-.
Wozniak MJ, Allan VJ. Carrier Motility. In: Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-. Table 2, Summary of cytoplasmic dynein 1 and dynactin subunit composition. Data for this table is summarized in refs. 4,8,166.
- Table 2, Summary of cytoplasmic dynein 1 and dynactin subunit composition. Data ...Table 2, Summary of cytoplasmic dynein 1 and dynactin subunit composition. Data for this table is summarized in refs. 4,8,166 - Madame Curie Bioscience DatabaseBookself
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