Figure 4. cAMP regulation of ZAK1, GSK3, the CAR4-PTPase, and pGSK3.

Figure 4

cAMP regulation of ZAK1, GSK3, the CAR4-PTPase, and pGSK3. Following a cAMP stimulus, ZAK1 specific activity exhibits a rapid but transient increase, which is paralleled closely by a transient increase in GSK3 tyrosine phosphorylation. GSK3 specific activity is also induced, but with kinetics that are slightly delayed relative to the increases of ZAK1 and the tyrosine phosphorylation of GSK3 (pGSK3). ZAK1 and GSK3 activation are regulated by CAR3. CAR4 regulates the activation of PTPase that de-phosphorylates and de-activates GSK3. CAR4 does not regulate ZAK1 activation or de-activation.

From: GSK3-Signal Regulation of Pattern Formation in Dictyostelium: Wnt-Like Pathways During Non-Canonical Multicellular Development

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