Figure 2. CAR3 and CAR4 antagonistically regulate GSK3 activity.

Figure 2

CAR3 and CAR4 antagonistically regulate GSK3 activity. GSK3 specific activity increases during multicellular mound formation (see Fig. 1) and subsequently declines as the patterned slug becomes committed to terminal differentiation (see Fig. 1). This developmental up-regulation is compromised in car3-nulls, while the repressive phase of GSK3 regulation is lost in car4-nulls.

From: GSK3-Signal Regulation of Pattern Formation in Dictyostelium: Wnt-Like Pathways During Non-Canonical Multicellular Development

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