Table 27Event rates used to populate model structure for indirect comparisons against no further testing

Population and technologyN StudiesProb of TLoC, P1Prob of outcomes in patient having TLoC during monitoringProb of arrhythmia in a patient not having TLoC during monitoring, P4
Arrhythmia, P2Normal, P3No ECG, (1-P2-P3)
Implantable event recorder
Suspected arrhythmia4 38,87,122,137133/253 =0.5378/133 =0.5939/133 =0.2916/133 =0.124/44* (3 studies)d =0.09
Unexplained after secondary tests1525,37,70,73,76,116,119–121,131,144, 160,170,171,197616/1102 =0.56300/616 =0.49276/616 =0.4540/616 =0.0623/175* (7 studies)e =0.13
External event recorder
Suspected arrhythmia118835/51 =0.6921/35 =0.6014/35 =0.400/35 =0.000/16 =0.00
Unexplained after secondary tests484,130,184,19698/192 =0.5117/98 =0.1749/98 =0.5032/98 =0.338/16 (1 study)f =0.50
48 hr Holter
Suspected arrhythmia11838/63 =0.134/8 =0.504/8 =0.500/8 =0.008/55 =0.15
Unexplained after initial tests111320/95 =0.211/20 =0.0519/20 =0.950/20 =0.0025/75 =0.33
Unexplained after secondary tests118412/51 =0.240/12 =0.0012/12 =1.000/12 =0.000/39 =0.00
24hr Holter
Suspected arrhythmia118922/140 =0.1615/22 =0.687/22 =0.320/22 =0.000/118 =0.00
Unexplained after initial tests1503/287 =0.012/3 =0.671/3 =0.330/3 =0.0055/284 =0.19

From: 5, Specialist assessment and diagnosis

Cover of Transient Loss of Consciousness (‘Blackouts’) Management in Adults and Young People
Transient Loss of Consciousness (‘Blackouts’) Management in Adults and Young People [Internet].
NICE Clinical Guidelines, No. 109.
National Clinical Guideline Centre for Acute and Chronic Conditions (UK).
Copyright © National Clinical Guideline Centre for Acute and Chronic Conditions, 2010.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.