CID/ML#Target NameIC50/EC50 (nM) [SID, AID]Anti-target Name(s)IC50/EC50 (μM) [SID, AID]Fold SelectiveSecondary Assay(s) Name: IC50/EC50 (nM) [SID, AID]
40225210/ML155N370S GC*330 nM [85267237, 2590]Alpha-glucosidase>57μM [85267237, 2577]>100-foldChaperone activity in N370S GC fibroblasts: 500 nM [85267237, 2587]
40225210/ML155Alpha-galactosidase> 57μM [85267237, 2578]>100-fold
*

GC = glucocerebrosidase, also known as beta-glucosidase.

From: Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 1

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