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Table 5A continuation of Table 4 - analogs with sulfonamide aromatic modifications having a thiophene at the two position

Image ml155fu98.jpg
Pubchem CIDPubchem SIDCompound numberR1N370S AC50 (μM)
1756412085267292138
Image ml155fu99.jpg
2.53
4513681592386629139
Image ml155fu100.jpg
4.00
4424643385267382140
Image ml155fu101.jpg
5.04
4424641485267357141
Image ml155fu102.jpg
1.00
4424641885267366142
Image ml155fu103.jpg
1.27
4424641585267358143
Image ml155fu104.jpg
3.18
4022521085267237144
Image ml155fu105.jpg
0.33
4022528885267286145
Image ml155fu106.jpg
1.01
485852085267280146
Image ml155fu107.jpg
0.50
4424642285267371147
Image ml155fu108.jpg
0.50
4424642885267377148
Image ml155fu109.jpg
1.59
4424643085267379149
Image ml155fu110.jpg
1.26
4424643185267380150
Image ml155fu111.jpg
2.53
4424641285267355151
Image ml155fu112.jpg
1.01
4424643285267381152
Image ml155fu113.jpg
0.50
4424643885267388153
Image ml155fu114.jpg
1.26
4424643685267386154
Image ml155fu115.jpg
1.01

From: Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 1

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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