Table 1SAR of 2,4-substituted thiazole aromatic analogs containing an aromatic substituent

Image ml200fu4.jpg
#CIDSIDNCGCR1AC50 (μM)Rate of induction (%)
299082387677807NCGC00183533-01
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1.22268
3a408459799367899NCGC00183552-01
Image ml200fu6.jpg
7.72167
3b4690768299367900NCGC00183553-01
Image ml200fu7.jpg
inactiveinactive
3c4690771699367908NCGC00183572-01
Image ml200fu8.jpg
1.94357
3d4414433287677815NCGC00183548-01
Image ml200fu9.jpg
7.72209
3e4414436287677821NCGC00183559-01
Image ml200fu10.jpg
inactiveinactive
3f4414436687677824NCGC00183564-01
Image ml200fu11.jpg
0.97504
3g4690772299367943NCGC00184945-01
Image ml200fu12.jpg
30.7464
3h4690775199367902NCGC00183560-01
Image ml200fu13.jpg
6.13100
3i4414436087677820NCGC00183557-01
Image ml200fu14.jpg
inactiveinactive
3j4690772799367927NCGC00184925-01
Image ml200fu15.jpg
inactiveinactive
3k4690766099367903NCGC00183561-01
Image ml200fu16.jpg
inactiveinactive
3l4690770199367910NCGC00183576-01
Image ml200fu17.jpg
30.74187
3m4414394787677833NCGC00183582-01
Image ml200fu18.jpg
1.22439
3n4690768399367941NCGC00184943-01
Image ml200fu19.jpg
3.87243
3o4414434087677812NCGC00183543-01
Image ml200fu20.jpg
inactiveinactive
3p4690769699367926NCGC00184924-01
Image ml200fu21.jpg
387100
3q4690774999367889NCGC00183527-01
Image ml200fu22.jpg
2.44386
3r4414433887677811NCGC00183540-01
Image ml200fu23.jpg
2.44274
3s4690769399367892NCGC00183539-01
Image ml200fu24.jpg
9.7264
3t4414394687677806NCGC00183531-01
Image ml200fu25.jpg
3.87288
3u4690771799367894NCGC00183542-01
Image ml200fu26.jpg
7.7257
3v4414433687677827NCGC00183571-01
Image ml200fu27.jpg
12.2453
3w80247599367893NCGC00183541-01
Image ml200fu28.jpg
2.44381
4a4414433487677816NCGC00183549-01
Image ml200fu29.jpg
inactiveinactive
4b4690769199367896NCGC00183547-01
Image ml200fu30.jpg
30.7557
4c4414315987677823NCGC00183563-01
Image ml200fu31.jpg
inactiveinactive
4d4690771199367897NCGC00183550-01
Image ml200fu32.jpg
24.4258
4e63076299367912NCGC00183578-01
Image ml200fu33.jpg
inactiveinactive
4f4414394887677810NCGC00183537-01
Image ml200fu34.jpg
7.72162
4g4414434287677813NCGC00183544-01
Image ml200fu35.jpg
inactiveinactive
4h4414315787677828NCGC00183573-01
Image ml200fu36.jpg
inactiveinactive
4i4690776099367907NCGC00183570-01
Image ml200fu37.jpg
inactiveinactive
4j4414435887677819NCGC00183556-01
Image ml200fu38.jpg
3.87356
4k4414434487677829NCGC00183575-01
Image ml200fu39.jpg
12.24130
4l4414436487677825NCGC00183565-01
Image ml200fu40.jpg
12.2451
4m4690770699367895NCGC00183545-01
Image ml200fu41.jpg
inactiveinactive
4n4690771999367909NCGC00183574-01
Image ml200fu42.jpg
3.8720
4o80033299367898NCGC00183551-01
Image ml200fu43.jpg
15.41254
4p4690768499367904NCGC00183566-01
Image ml200fu44.jpg
inactiveinactive
4q4690774299367901NCGC00183558-01
Image ml200fu45.jpg
inactiveinactive
4r4690773199367906NCGC00183569-01
Image ml200fu46.jpg
9.7249
4s4414435087677832NCGC00183581-01
Image ml200fu47.jpg
7.7251
4t4414435287677817NCGC00183554-01
Image ml200fu48.jpg
inactiveinactive
4u4414435687677814NCGC00183546-01
Image ml200fu49.jpg
inactiveinactive
4v4414436887677822NCGC00183562-01
Image ml200fu50.jpg
7.72534
4w4414437087677826NCGC00183567-01
Image ml200fu51.jpg
15.41100
4x4690767599367891NCGC00183538-01
Image ml200fu52.jpg
30.74369

From: Discovery, SAR and Biological Evaluation of Aryl-thiazol-piperidines as SMN Modulators

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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