Behavioral Interventions
  • Early intensive behavioral and developmental interventions such as the UCLA/Lovaas Model improve cognitive, language, and adaptive outcomes in certain subgroups of children. Image clinautismf2.jpg
  • The evidence is insufficient to understand the effectiveness, benefits, or adverse events from any other behavioral interventions. Image clinautismf1.jpg
Medical Interventions

Benefits

  • Aripiprazole ( Image clinautismf4.jpg) and risperidone ( Image clinautismf2.jpg) reduce challenging and repetitive behaviors when compared with placebo.
  • Secretin does not improve language, cognition, behavior, communication, autism symptom severity, or socialization. Image clinautismf4.jpg
  • The evidence is insufficient to understand the effectiveness and benefits from all other medical interventions, including serotonin-reuptake inhibitors and stimulant medications. Image clinautismf1.jpg

Harms

  • Aripiprazole and risperidone are associated with significant weight gain, sedation, and extrapyramidal effects. Image clinautismf4.jpg
  • The evidence is insufficient to understand the adverse events from all other medical interventions, including serotonin-reuptake inhibitors and stimulant medications. Image clinautismf1.jpg
Educational Interventions
  • The evidence is insufficient to understand the effectiveness, benefits, or adverse events from any educational intervention. Image clinautismf1.jpg
Allied Health and CAM Interventions
  • The evidence is insufficient to understand the effectiveness, benefits, or adverse events from any allied health or CAM intervention. Image clinautismf1.jpg
Confidence Scale

High: Image clinautismf4.jpg There are consistent results from good-quality studies. Further research is very unlikely to change the conclusions.

Moderate: Image clinautismf3.jpg Findings are supported, but further research could change the conclusions.

Low: Image clinautismf2.jpg There are very few studies, or existing studies are flawed.

Insufficient: Image clinautismf1.jpg Signifies that evidence is either unavailable or does not permit estimation of an effect.

From: Comparative Effectiveness of Therapies for Children With Autism Spectrum Disorders

Cover of Comparative Effectiveness Review Summary Guides for Clinicians
Comparative Effectiveness Review Summary Guides for Clinicians [Internet].

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