Figure 1. Migratory neural crest cells give rise to bone and cartilage of the head and face.

Figure 1

Migratory neural crest cells give rise to bone and cartilage of the head and face. A) Coloured scanning electron micrograph of head region of a mouse embryo at 8.0 days of development. Neural crest cells (represented by green dots) are induced to form at the border between the neural plate (blue—np) and surface ectoderm (yellow—se). Neural crest cells migrate away from the neural plate following a path beneath the surface ectoderm and over the surface of the mesoderm. B) Patterns of neural crest cell migration in mouse embryo at 8.5 days of development as detected by Sox10 RNA in situ hybridization. At this stage neural crest cells have emigrated from the forebrain, midbrain and hindbrain. Neural crest cells completely cover the frontonasal region and the maxillary component of the first branchial arch. C) At embryonic day 9.5, Sox10 positive neural crest cells are associated with neurogenic neural crest cells that contribute to the craniofacial placodes and ganglia. D) A skeletal preparation of a mouse embryo at 14.5 days of development reveals early condensations of bone (red) and cartilage (blue), which, in the head and face, are primarily derived from neural crest. E) The precise morphology of craniofacial bone and cartilage elements are evident at 17.5 days of development.

From: Neural Crest Cell Plasticity: Size Matters

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