Figure 7. The early steps in the determination and polarisation of the Drosophila oocyte.

Figure 7

The early steps in the determination and polarisation of the Drosophila oocyte. The early differentiation of the oocyte is a multistep process. Genes involved at each step are indicated on the figure. The lists are not exhaustive. Actors of the cytoplasmic differentiation are in red, whereas regulators of the cell cycle are in blue. The top panel shows a 4-cell cyst (α-spectrin, in red, marks the fusome and anilin, in green, marks the ring canals). One cell has more fusome than the other cells (arrow). The panel below shows a 16-cell cyst after the last division with one cell having more fusome (arrow). There are three different pathways to restrict the oocyte identity to one cell (asterik). The left panel shows the actin in red and the synaptonemal complex in green. In the middle panels, a nuclear GFP is in green, and Orb (an oocyte-specific cytoplasmic protein) is in red. On the right panels, the γ-tubulin marks the centrosomes in red, the α-spectrin marks the fusome in blue, and a nuclear GFP is in green. Orb and the centrosomes are clearly seen migrating from the anterior of the oocyte to the posterior, revealing the repolarisation of the oocyte. (Reprinted from: Huynh JR, St Johnston D, Curr Biol 14:R438-449, ©2004, with permission from Elsevier.15) A color version of this figure is available online at

From: Fusome as a Cell-Cell Communication Channel of Drosophila Ovarian Cyst

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