Figure 4. Activator-coactivator interactions in mitochondrial biogenesis.

Figure 4

Activator-coactivator interactions in mitochondrial biogenesis. Nuclear respiratory factor 1 (NRF-1) is representative of transcription factors that act on nuclear genes whose products are required for expression and function of the mitochondrial respiratory apparatus. NRF-1 is a target for a small family of transcriptional coactivators whose members include PRC and PGC-1. The expression of these coactivators is regulated by proliferative, thermogenic and gluconeogenic signals thus placing NRF-1 and its target genes under the control of key signaling pathways. Activator-coactivator interactions may serve an integrative function in regulating cellular energetics.

From: Molecular Biology of the OXPHOS System

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