Figure 13. Effect of M40403 on IL-2 treatment response of murine renal carcinoma.

Figure 13

Effect of M40403 on IL-2 treatment response of murine renal carcinoma. Mice (8 per group) bearing subcutaneous implants of RENCA renal adenocarcinoma were treated with IL-2 (180,000 IU i.p. b.i.d. for 5 days) with or without M40403 (3 mg/kg b.i.d. s.c.). The product of bidimensional tumor measurements (in cm2 ±SD) is shown. Neither IL-2 nor M40403 alone influenced tumor growth (both p>0.10). Tumor growth in the IL-2 + M40403 group was markedly decreased compared to untreated controls (p<0.0001).

From: Evaluation of a Superoxide Dismutase Mimetic As an Adjunct to Interleukin 2 Based Cancer Therapy

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