Figure 11. Effect of M40403 on IL-2 treatment response of RD-995 pulmonary metastases.

Figure 11

Effect of M40403 on IL-2 treatment response of RD-995 pulmonary metastases. Syngeneic C3H/HeN mice were injected with 106 RD-995 tumor cells i.v. Beginning 3 days after tumor injection, groups of mice received either IL-2 alone (180,000 IU i.p. for 5 days), M40403 (3 mg/kg s.c. b.i.d.) alone or the combination of both. Untreated mice served as a control. On day 14, mice were sacrificed by anesthetic overdose. After thoracotomy, India ink solution was instilled into the trachea of each mouse to expand the lungs. Lungs were then excised and bleached in 5-10 ml Fekete's solution and scored for pulmonary metastases in a blinded fashion.33 Statistical analysis was performed using Student t-test.

From: Evaluation of a Superoxide Dismutase Mimetic As an Adjunct to Interleukin 2 Based Cancer Therapy

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