Figure 2. Comparison of the structure of HLA-G and Qa-2.

Figure 2

Comparison of the structure of HLA-G and Qa-2. The extracellular domains of the proteins are similar consisting of a trimer complex of three noncovalently bound components: the MHC Class I heavy (alpha) chain containing alpha 1, alpha 2 and alpha 3 domains, the small 9-11 amino acid displayed peptide, and beta2 microglobulin (β2m). HLA-G has a transmembrane domain and a truncated cytoplasmic domain consisting of 6 amino acids. Qa-2 is post-translationally modified by the addition of a glycosylphosphatidyl inositol (GPI) tail which anchors the protein in the outer leaflet of the cell membrane. Qa-2 does not contain transmembrane or cytoplasmic domains.

From: MHC Molecules of the Preimplantation Embryo and Trophoblast

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