Table 4.3Use of uterine artery Doppler velocimetry to predict pregnancy-aggravated hypertension, superimposed pre-eclampsia, IUGR and placental abruption in women with chronic hypertension

StudyPopulation demographic characteristicsGestational ageIndexParameterPre-eclampsiaNotes
Frusca et al. (1998), Italy75n = 78 chronic hypertension (diastolic blood pressure> 90 mmHg, no proteinuria)24–25 weeksRI: abnormal = > 2SD above normal mean for gestational ageSensitivity:76%Exclusion criteria: multiple pregnancy, fetal structural or chromosomal abnormalities
Pre-pregnancy antihypertensives were stopped at first visit (7–10 weeks), restarted if diastolic blood pressure exceeded 100 mmHg. All women took 50 mg/day aspirin from 12 weeks
Endpoints: pregnancy aggravated hypertension (diastolic blood pressure increase of more than 15 mmHg), superimposed pre- eclampsia, IUGR and placental abruption
Specificity:84%
PPV:64%
NPV:91%

NPV = negative predictive value; PPV = positive predictive value; RI = resistance index

From: 4, Management of pregnancy with chronic hypertension

Cover of Hypertension in Pregnancy
Hypertension in Pregnancy: The Management of Hypertensive Disorders During Pregnancy.
NICE Clinical Guidelines, No. 107.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2010 Aug.
Copyright © 2011, Royal College of Obstetricians and Gynaecologists.

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