Figure 5. Effect of protonation on leaving group pKa and acyl group reactivity.

Figure 5

Effect of protonation on leaving group pKa and acyl group reactivity. Direct amide hydrolysis (top) is disfavored because the RNH leaving group is unstable; hydrolysis of a protonated amide (bottom) occurs much more readily with the RNH2 leaving group.

From: Ribozyme-Catalyzed Genetics

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