Table 1Structural and functional abnormalities of tumor vasculature

Decreased vascular density
Heterogeneous distribution of microvessels
Increased presence of sinusoids, dead ends and arterio-venous anastomosis
Lack of arteriolar vessels
Decreased perfusional pressure and increased geometric resistance absence of lymphatics, increased TIF, hemoconcentration, increased viscosity
Incomplete basement membrane and absence of smooth muscle
Decreased stabilization for absence of pericytes and mural cells
Decreased leukocyte-endothelium adhesion
Absence of innervation and regulation according to metabolic demand

From: Influence of Tumor Microenvironment on Thermoresponse: Biologic and Clinical Implications

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