Figure 1. Transcription-driven supercoils.

Figure 1

Transcription-driven supercoils. Tracking RNA polymerase generates positive supercoils in the template DNA ahead of it and negative supercoils behind it. “B” represents a topological barrier. It does not necessarily require attachment of DNA to cellular structures. Certain sequence-specific binding proteins can form the topological barrier upon binding to DNA.35 Modified from Hirose S, Ohta T. Cell Struct Funct 1990;15:133-135.

From: Possible Roles of DNA Supercoiling in Transcription

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