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Carson S, Thakurta S, Low A, et al. Drug Class Review: Long-Acting Opioid Analgesics: Final Update 6 Report [Internet]. Portland (OR): Oregon Health & Science University; 2011 Jul.

Cover of Drug Class Review: Long-Acting Opioid Analgesics

Drug Class Review: Long-Acting Opioid Analgesics: Final Update 6 Report [Internet].

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Evidence Tables

Evidence Table 1. Update 6: Data abstraction of head-to-head trials

Evidence Table 2. Update 6: Data abstraction of placebo-controlled trials

Evidence Table 3. Update 6: Quality assessment of trials

Evidence Table 4. Original Report through Update 5: Data abstraction and quality assessment of randomized controlled trials comparing a long-acting opioid with a long-acting opioid

Evidence Table 5. Original Report through Update 5: Data abstraction and quality assessment of randomized controlled trials comparing a long-acting opioid with a short-acting opioid

Evidence Table 6. Original Report through Update 5: Data abstraction and quality assessment of randomized controlled trials comparing a long-acting opioid to placebo or nonopioid

Evidence Table 7. Original Report through Update 5: Data abstraction and quality assessment of observational studies

Evidence Table 8. Update 5: Quality assessment of trials

Abbreviations used in evidence tables

ACR

American College of Rheumatology

ACT

Active-control trial

AE

Adverse event

ALO-01

morphine sulfate and naltrexone hydrochloride ER

ANCOVA

Analysis of covariance

ANOVA

Analysis of variance

ASA

Aspirin

bid

Twice daily

BMI

Body mass index

BTDS

Buphrenorphine transdermal system

CCT

Controlled clinical trial

CI

Confidence interval

CNS

Central nervous system

CR

Controlled release

CV

Cardiovascular

CVS

Cardiovascular system

d

Day

DB

Double-blind

dL

Deciliter

ECG

Electrocardiogram

EEG

Electroencephalogram

EF

Ejection fraction

ER

Extended release

ER

Extended release

ERMS

Extended release morphine sulfate

FDA

US Food and Drug Administration

FU

Follow-up

g

Gram

GI

Gastrointestinal

GP

General practitioner

h

Hour

HDL-C

High density lipoprotein cholesterol

HMO

Health maintenance organization

HR

Hazard ratio

HRQOL

Health-related quality of life

ICD-10

International Classification of Diseases, Tenth Revision

ICD-9

International Classification of Diseases, Ninth Revision

IR

Immediate release

ITT

Intent-to-treat

L

Liter

LA

Long acting

LBP

Low back pain

LDL-C

Low-density lipoprotein cholesterol

LOCF

Last Observation Carried Forward

LS means

Least squares means

MANCOVA

Multivariate analysis of covariance

mcg

Microgram

mg

Milligram

min

Minute

mL

Milliliter

mo

Month

MOS

Medical Outcomes Study

N

Sample size (entire sample)

n

Subgroup sample size

NA

Not applicable

NR

Not reported

NRS

11-point Likert Numeric Rating Scale

NS

Not significant

NSD

No significant difference

OA

Osteoarthritis

OR

Odds ratio

OROS

Osmotic release oral system

P

P value

P

Placebo

PCT

Placebo-controlled trial

PGA

Patient Global Assessment

PGIC

Patient Global Impression of Change

PPY

Per person year

qd

Once daily

QOL

Quality of life

RCT

Randomized controlled trial

RR

Relative risk

SB

Single-blind

SD

Standard deviation

SE

Standard error

SR

Sustained release

SSRIs

Selective serotonin reuptake inhibitors

tid

Three times daily

VAS

Visual analog scale

vs.

Compared with (versus)

WD

Withdrawal

WOMAC

Western Ontario and McMaster Universities Osteoarthritis Index

XR

Extended release

y

Year

Copyright © 2011 by Oregon Health & Science University.
Bookshelf ID: NBK62333
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