Figure 1. The role of initiator and effector caspases in CD95-mediated apoptosis.

Figure 1

The role of initiator and effector caspases in CD95-mediated apoptosis. The amount of caspase-8 generated at the CD95 death-inducing signaling complex (DISC) determines whether a cell undergoes apoptosis through a mitochondrial dependent (Type II) or mitochondrial independent (Type I) pathway. In addition to activation of downstream effector caspases the initial activation of caspase-8 at the DISC also regulates clustering and internalization of CD95 in Type I cells.78 CD95 is shown as a trimer with bound CD95 ligand.

From: Apoptosis Dependent and Independent Functions of Caspases

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