ClinicalThere is no statistically significant difference between sympathomimetics and beta-blockers in the number of people with visual field progression at 12 months follow up. (LOW QUALITY)
There is no statistically significant difference between sympathomimetics and beta-blockers in reducing IOP from baseline at 12 months follow up. (LOW QUALITY)
There were no studies which reported the number of patients with an acceptable IOP.
Significantly more allergic reactions were experienced by patients using sympathomimetics than beta-blockers at 12 months follow up. No patient using beta-blockers experienced an allergic reaction. (MODERATE QUALITY)
There is no statistically significant difference between sympathomimetics and beta-blockers in the number of patients experiencing fatigue or drowsiness at 12 months follow up. (MODERATE QUALITY)
EconomicSympathomimetics are more costly than beta-blockers but more effective at controlling IOP without causing adverse events, although this is not significant. However due to the small sample size, the cross over between interventions, and the contradiction with the clinical evidence, the findings of this study were deemed unreliable.

From: 8, Treatment of chronic open angle glaucoma

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Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
National Collaborating Centre for Acute Care (UK).
Copyright © 2009, National Collaborating Centre for Acute Care.

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