Table 8-106Fixed combination of carbonic anhydrase inhibitors + beta-blockers vs. prostaglandin analogues - Clinical summary of findings

OutcomeInterventionControlRelative riskAbsolute effectQuality
Mean change in IOP from baseline3035not applicableMD −0.30 (−1.32 to 0.72)Moderate
Number of patients experiencing a respiratory adverse event1/30 (3.3%)0/35 (0%)RR 3.48 (0.15 to 82.48)not estimable (a)Low
Number of patients with hyperaemia4/30 (13.3%)18/35 (51.4%)RR 0.26 (0.1 to 0.68)380 fewer per 1000 (from 164 fewer to 463 fewer)Moderate
a

An absolute effect calculation is not possible as there are no events in the control arm of the study.

From: 8, Treatment of chronic open angle glaucoma

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Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
National Collaborating Centre for Acute Care (UK).
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