Table 8-90Prostaglandin analogues vs. beta-blockers - Clinical summary of findings

OutcomeInterventionControlRelative riskAbsolute effectQuality
Mean change in IOP from baseline13421333not applicableMD −1.32 (−1.79 to −0.84)Moderate
Number of patients with an acceptable IOP546/971 (56.2%)376/953 (39.5%)RR 1.54 (1.21 to 1.96)213 more per 1000 (from 83 more to 379 more)Moderate
Number of patients experiencing a respiratory adverse event25/330 (7.6%)24/233 (10.3%)RR 0.59 (0.35 to 1)42 fewer per 1000 (from 67 fewer to 0 more)Moderate
Number of patients experiencing a cardiovascular adverse event99/997 (9.9%)90/713 (12.6%)RR 0.87 (0.67 to 1.13)16 fewer per 1000 (from 42 fewer to 16 more)Moderate
Number of patients experiencing an allergic reaction7/332 (2.1%)3/229 (1.3%)RR 1.25 (0.31 to 5.09)3 more per 1000 (from 9 fewer to 53 more)Moderate
Number of patients with hyperaemia582/1778 (32.7%)108/1343 (8%)RR 3.58 (2.97 to 4.32)206 more per 1000 (from 158 more to 266 more)High

From: 8, Treatment of chronic open angle glaucoma

Cover of Glaucoma
Glaucoma: Diagnosis and Management of Chronic Open Angle Glaucoma and Ocular Hypertension.
NICE Clinical Guidelines, No. 85.
National Collaborating Centre for Acute Care (UK).
Copyright © 2009, National Collaborating Centre for Acute Care.

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