Figure 2. The hematopoietic tree.

Figure 2

The hematopoietic tree. A) Schematic representation of the main lineage commitment steps in mouse hematopoiesis. The hematopoietic stem cell (HSC) gives rise to the common lymphoid progenitor (CLP) and the common myeloid progenitor (CMP). CLPs give rise exclusively to B and T cells, while CMPs give rise to erythrocyte-megakaryocyte progenitors (EMP) and granulocyte-monocyte progenitors (GMP). Hematopoietic factors relevant for this chapter are indicated. Pictures are extracted from different web sites and available upon request. B) Summary of events during hematopoiesis in Drosophila. Hemocytes are derived from Glial-cells-missing (Gcm)-expressing prohemocytes. The GATA factor Serpent and the Runx factor Lozenge cooperate to give rise to crystal cell whereas Serpent and the FOG factor U-Shaped repress this pathway.

From: CtBP and Hematopoietic Transcriptional Regulators

Cover of Madame Curie Bioscience Database
Madame Curie Bioscience Database [Internet].
Austin (TX): Landes Bioscience; 2000-2013.
Copyright © 2000-2013, Landes Bioscience.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.