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Table 1Factor involved in nuclear morphologic changes during cell death programs

Nuclear Condensation
DNA Repair and Cell DeathNucleaseProtease
p53
PARPsCaspases
p33ING1b CADCathepsins
ATM,ATRCa2+/Mg2+-dependent
BLMEndonucleaseGranzyme B
BRAC1Ca2+/Mg2+-dependentCalpain
DNA-PKEndonuclease
MSH2, MSH6, MLH1Ca2+-regulated serine
PMS2EndoGProteases
REF-1/ApeGAAD/NM23-H1Histone-associated
Tip60Protease
WRN
XPB,XPDAcinus, AIF

ATM, ataxia telangiectasia mutated; ATR, ATM-related; BLM, protein encoded by Bloom syndrome gene; BRCA1, protein encoded by breast cancer-associated gene 1; DNA-PK, DNA protein kinase; MLH1, MutL homolog 1; MSH2, MSH6, MutS homologs 2 and 6, respectively; PMS2, postmeiotic segregation increased (S. cerevisiae) 2; Ref-1/Ape, redox factor-1/AP endonuclease; Tip60, Tat-interactive protein 60kDa; WRN, protein encoded by Werner syndrome gene; XPB, XPD, proteins deficient in Xeroderma pigmentosum complementation groups B and D, respectively; GAAD/NM23-H1, granzyme A-activated Dnase/nonmetastatic protein 23, HOMOLOG 1.

From: PARP and the Release of Apoptosis-Inducing Factor from Mitochondria

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