Table 1Murine caspases and caspase-deficient mice

CaspaseDev. DefectsApoptotic DefectsOther DefectsReferences
caspase-1nonenoneIL-1α, -1β & -18 processing, endotoxin resistant 12,13
caspase-2noneoocytes (decreased PCD) facial motor neurons (accelerated PCD)N/D 42
caspase-3Neuronal (perinatally lethal*)morphology/DNA fragmentation (MEFs, hepatocytes, thymocytes) Neutrophil turnover, lymphocyte AICD*  5,11
caspase-6noneN/DB-cell maturation?unpublished
caspase-7embryonic lethalN/DN/Dunpublished
caspase-8embryonic lethalembryonic deathreceptor pathway (MEFs)N/D 10
caspase-9Neuronal, embryonic lethal**mitochondrial pathway, (thymocytes)N/D 6,7
caspase-11normalnoneL-1α, -1β & -18 processing, endotoxin (LPS) resistant 14
caspase-12normalER-pathwayN/D 15
caspase-14not yet reported   

* The perinatal lethality of caspase-3−/− mice and defective AICD observed in caspase-3−/− lymphocytes depend on genetic background.6

** A very small percentage of caspase-9 knockout mice (<2%) develop normally. N/D=not determined

From: Learning from Deficiency: Gene Targeting of Caspases

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