Table 1ABL-interacting proteins relevant to the control of cell death

Name* Gene ID* Molecular FunctionFunction Relative to ABLRef.
ATM472Protein kinase belonging to the PI-3 kinase super-family involved in DNA damage signal transductionPhosphorylation and activation of ABL kinase21, 22, 120, 121
ATR545ATM-related protein kinase involved in DNA damage signal transduction and DNA replicationInteraction with BCR-ABL appears to impair ATR function122
BRCA1672A nuclear scaffolding protein with E3-ligase activity and involved in DNA repair and DNA damage signal transductionInteraction with ABL and phosphorylation of its C-terminus by ABL kinase123
DDB11643The large subunit of a heterodimeric DNA damage-binding protein involved in the repair of UV-adducts in DNAPhosphorylation by ABL kinase to suppress UV-DDB activity124
MDM24193E3-Ubiquitin ligase required for the degradation of p53Phosphorylation by ABL kinase to neutralize its degradation of TP5365, 66
NCSTN (APH2)23385A protein with DHHC zinc finger domainInteraction with and co-localization of ABL to ER to induce cell death91
POLR2A5430RNA polymerase IIPhosphorylation of its C-terminal domain (CTD) by ABL kinase to regulate transcription14, 15, 74,125
PRKDC (DNAPK)5591The catalytic subunit of DNA-dependent protein protein kinase (DNA-PK) belonging to the PI-3 kinase super-family, involved in non-homologous end joining repair of double stranded breaks.Phosphorylation by ABL linked to inhibition of DNA-PK activity34, 126, 127
RAD515888Catalyzes strand evasion during homologous recombination, similar to E. coli RecA and Saccharomyces cerevisiae Rad51.Phosphorylation by ABL kinase correlates with its nuclear foci formation128, 129
RAD525893A cofactor of Rad51 in the strand invasion reaction during homologous recombinationPhosphorylation by ABL kinase correlates with its nuclear foci formation130, 131
RAD9A5883A subunit of the 9-1-1 complex that resembles the homo-trimeric PCNA DNA clamp. It also possesses 3' -5' exonuclease. The 9-1-1 complex is involved in the recognition of damaged DNA to stimulate repair and signaling pathwaysPhosphorylation by ABL kinase at its BH3 domain enhances the binding of the BH3 domain to Bcl-xL85
RB15925The retinoblastoma tumor suppressor protein, a nuclear scaffolding protein involved in transcription regulation.Binding to ABL kinase domain and inhibits ABL activity45, 50, 132-135
TOP17150Topoisomerase IPhosphorylation and activation by ABL kinase136
TP537157A transcription factor and a tumor suppressorPhosphorylation by ABL kinase to increase its transcriptional activity67, 137
TP737161A transcription factor belonging to the p53-familyPhosphorylation by ABL kinase to increase protein stability and transcription activity26, 35, 36
WRN7486A member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases, loss of WRN causes premature aging.Phosphorylation by ABL kinase to inhibit its exonulcease and helicase activities138
NFKB IA4792Inhibitor of NF-kB that retains NF-kB in the cytoplasmPhosphorylation by ABL kinase to induce its nuclear accumulation and inhibition of NF-κB76
PRDX15052A member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides.Oxidative stress-induced protein inhibitor of ABL kinase139

*Nomenclatures (in alphabetical order) and IDs of the corresponding human genes are given in conformation to the Entrez Gene database of NCBI.

From: Abl and Cell Death

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