Figure 10. Evolution of a potential thrombin inhibitor by TOPAS.

Figure 10

Evolution of a potential thrombin inhibitor by TOPAS. Twelve subsequent parent structures of an evolutionary design experiment are shown (Generation 1 to 12). NAPAP served as the template structure, and the Tanimoto index was used as fitness measure.

From: Evolutionary De Novo Design

Cover of Madame Curie Bioscience Database
Madame Curie Bioscience Database [Internet].
Austin (TX): Landes Bioscience; 2000-.
Copyright © 2000-2013, Landes Bioscience.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.