Figure 9. MDM2 promotes p53 nuclear export.

Figure 9

MDM2 promotes p53 nuclear export. Cells were transfected with DNAs encoding the indicated forms of p53 and MDM2. Localization of p53 and MDM2 was then monitored by immunofluorescence staining. Representative pictures are shown. Wild-type p53 localizes to the nucleus when expressed alone, but is exported to the cytoplasm when expressed with MDM2. This nuclear export of p53 requires the NES located in the p53 C terminus, and the RING finger domain of MDM2.

From: MDM2: RING Finger Protein and Regulator of p53

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