| Animal Models of Cerebral Ischemia | Possible Correlate in Man | Histological Findings |
|---|---|---|
| -global ischemia | ||
| a. permanent (circulatory arrest) | hanging, circulatory arrest, drowning | brain swelling, cell death |
| b. transient (e.g. 4-vessel occlusion) | circulatory arrest with resuscitation, near-drowning | delayed neuronal death astrogliosis |
| -focal ischemia | ||
| a. permanent (e.g. MCAo) | hemispheral stroke (thrombotic or embolic occlusion without recanalisation) | pannecrosis, hemispheral swelling |
| b. transient (e.g. MCAo/reperfusion) | stroke with spontaneous recanalization or thrombolytic therapy (“reperfusion injury”) | pannecrosis, inflammation |
| c. mild (e.g. brief MCAo/reperf.) | transient ischemic attack (?) | delayed neuronal death astrogliosis |
From: Neuroprotective Strategies in Animal and in Vitro Models of Neuronal Damage: Ischemia and Stroke
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