Figure 1. A, Tissue section through arcuate nucleus (arc) of hypothalamus from a 10-day-old mouse (control; ×150).

Figure 1

A, Tissue section through arcuate nucleus (arc) of hypothalamus from a 10-day-old mouse (control; ×150). No signs of pathology are present. B, Section trough arcuate nucleus (arc) from a 10-day-old mouse treated orally with 1 g/kg sodium glutamate (×150). There is a considerable number of necrotic cells within the arcuate region. Reprinted with permission from Olney JW, Ho OL. Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine. Nature 1970; 227:609-611, copyright 1970 Macmillan Publishers Ltd.

From: Excitatory Amino Acid Neurotoxicity

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