Figure 7. The hedgehog signaling pathway.

Figure 7

The hedgehog signaling pathway. In the absence of Hh ligand, Ptc inhibits the activity of Smo to block the downstream signaling cascade. Hh binding to Ptc relieves Smo from its inhibition to initiate a signaling cascade that results in the activation of the Gli family of transcription factors and subsequent transcription of Gli responsive genes.

From: Embryonic Salivary Gland Branching Morphogenesis

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