Table 2Effect of NMD on expression of tumor-suppressor genes

GeneExperimental DataReference(s)
BRCA1 NMD demonstrated for many transcripts containing PTCs.14
Expression of NMD-insensitive C-terminal truncation mutations leads to increased chemoresistance, decreased apoptosis, increased tumorigenicity and decreased survival time.20, 21
TP53 PTCs associated with decreased or absent mRNA and protein.15-18
Expression of NMD-insensitive C-terminal truncation mutations leads to tumorigenesis.22
WT1 PTCs associated with absent mRNA.19
NMD-insensitive PTC-containing mRNAs encode truncated protein that inhibits ability of wild-type protein to activate transcription and alters subnuclear localization of wild-type protein.23, 24

Reproduced from reference 1.

From: NMD and Human Disease

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